Abstract: A deterioration determining apparatus includes: an operating condition acquirer to acquire an operating condition of a processing device; a processing state data acquirer to acquire processing state data detected by a sensor attached to the processing device; a learning model generator to conduct machine learning using, as learning data, the operating condition and the processing state data so as to preliminarily generate a learning model concerning the operating condition and the processing state data; an actual data acquirer to acquire actual data that is the processing state data at a determining time; a predicted data acquirer to acquire, using the learning model, predicted data that is the processing state data for the operating condition at the determining time; and a determiner to determine the degree of deterioration in the processing device in accordance with the degree of divergence between the actual data and the predicted data.

Abstract: A device for assisting molding condition determination includes a molding state data adjustment amount obtaining unit and a molding condition element adjustment amount obtaining unit. The molding state data adjustment amount obtaining unit obtains, using a first learning model, a molding state data adjustment amount having a value equivalent to a difference between molding state data detected by a sensor and a molding state data target value. The molding condition element adjustment amount obtaining unit obtains, using a second learning model, an adjustment amount for a molding condition element corresponding to the molding state data adjustment amount.

Abstract: The purpose of the present invention is to provide a method for producing 6-bromo-3-hydroxy-2-pyrazinecarboxamide in which the content ratio of impurities is reduced. This production method includes a step of obtaining 6-bromo-3-hydroxy-2-pyrazinecarboxamide crystal having diffraction angles expressed in degrees 2? of 5.5, 20.1, 23.7, 26.7, 27.5, and 28.1° and/or diffraction angles expressed in degrees 2? of 7.1, 21.4, 25.2, 25.7, 27.1, and 28.8° in powder X-ray diffraction.

Abstract: The purpose of the present invention is to provide a method for producing 6-bromo-3-hydroxy-2-pyrazinecarboxamide in which the content ratio of impurities is reduced. This production method includes a step of obtaining 6-bromo-3-hydroxy-2-pyrazinecarboxamide crystal having diffraction angles expressed in degrees 2? of 5.5, 20.1, 23.7, 26.7, 27.5, and 28.1° and/or diffraction angles expressed in degrees 2? of 7.1, 21.4, 25.2, 25.7, 27.1, and 28.8° in powder X-ray diffraction.

Abstract: The purpose of the present invention is to provide a method for producing 6-bromo-3-hydroxy-2-pyrazinecarboxamide in which the content ratio of impurities is reduced. This production method includes a step of obtaining 6-bromo-3-hydroxy-2-pyrazinecarboxamide crystal having diffraction angles expressed in degrees 2? of 5.5, 20.1, 23.7, 26.7, 27.5, and 28.1° and/or diffraction angles expressed in degrees 2? of 7.1, 21.4, 25.2, 25.7, 27.1, and 28.8° in powder X-ray diffraction.

Abstract: Crystals of 5-cyclopropyl-2-((1-(3-fluorobenzyl)-1H-indol-5-yl)amino)nicotinic acid having diffraction peaks at diffraction angles (2?) of 12.2±0.2, 17.2±0.2, 19.4±0.2, 24.1±0.2, and 27.1±0.2° or diffraction angles (2?) of 12.9±0.2, 15.5±0.2, 21.2±0.2, 21.7±0.2, and 25.9±0.2° in powder x-ray diffraction have excellent stability, are easy to handle, and are useful as a drug substance of pharmaceuticals to be used in treatments such as the prevention or treatment of diseases involving keratinocyte hyperproliferation.

Abstract: There is provided a container lid (2) configured as follows: Even if radially outward or upward movement and radially inward or downward movement of a grip piece (6) and a connecting piece (12) of a shell (4) are repeatedly performed when the container lid mounted on a mouth-neck section (32) of a container is to be removed from the mouth-neck section, the connecting piece is sufficiently reliably prevented from being broken at a boundary between a portion of the connecting piece of the shell surrounded by a connecting section (26) of the grip piece and a portion thereof not surrounded by the connecting section of the grip piece. The grip piece is provided with an extension section (30) extending out upwardly from the upper end of an inner surface of the connecting section along an inner peripheral surface of a skirt wall (10).

Abstract: Crystals of 5-cyclopropyl-2-((1-(3-fluorobenzyl)-1H-indol-5-yl)amino)nicotinic acid having diffraction peaks at diffraction angles (2?) of 12.2±0.2, 17.2±0.2, 19.4±0.2, 24.1±0.2, and 27.1±0.2° or diffraction angles (2?) of 12.9±0.2, 15.5±0.2, 21.2±0.2, 21.7±0.2, and 25.9±0.2° in powder x-ray diffraction have excellent stability, are easy to handle, and are useful as a drug substance of pharmaceuticals to be used in treatments such as the prevention or treatment of diseases involving keratinocyte hyperproliferation.

Abstract: The purpose of the present invention is to provide a method for producing 6-bromo-3-hydroxy-2-pyrazinecarboxamide in which the content ratio of impurities is reduced. This production method includes a step of obtaining 6-bromo-3-hydroxy-2-pyrazinecarboxamide crystal having diffraction angles expressed in degrees 20 of 5.5, 20.1, 23.7, 26.7, 27.5, and 28.1° and/or diffraction angles expressed in degrees 2? of 7.1, 21.4, 25.2, 25.7, 27.1, and 28.8° in powder X-ray diffraction.

Abstract: An easily openable container lid has a shell and a liner embossed on the inner surface of a top panel wall and a pair of scores formed in the shell. The liner is adhered over the entire surface thereof to the inner surface of the top panel wall. At least second portions of the pair of scores are formed by forming grooves on the inner surface side of the shell, and are extended along the peripheral edge of the liner radially outwardly of the liner. Moreover, the liner has a thin-walled central section and a thick-walled peripheral edge section, and is configured to have a downwardly protruding outer sealing ridge formed in a radially outward region of the thick-walled peripheral edge section. The thickness of the thin-walled central section and the thickness of the thick-walled peripheral edge section are set within required ranges.

Abstract: A metal cap in which a linear to be held to a cap body and separable from the cap body can be formed by a series of operations for forming the cap body and press molding the liner. The liner of the metal cap has a double-layer structure including a barrier layer on a top panel wall side and a sealing layer on the inner side of the cap body, and the barrier layer is temporarily bonded to the top panel wall with a weak adhesive at the time of molding the barrier layer and separated from the top panel wall by the natural cooling of the barrier layer after molding.

Abstract: Provided is an airtight container for positive pressure beverage that has a cap which is able to improve airtightness. The airtight container for beverage is provided with a beverage container and a cap. The beverage container has a body portion and a flange. The flange is continuous with an upper portion of the body portion and defines an orifice. The cap is attached to the beverage container so as to seal the orifice. The cap has a liner and an exterior body. The liner has a thin liner portion for sealing a lower side portion of the flange and a thick liner portion for sealing an upper side portion of the flange. The exterior body is fixed to the flange so as to cover the liner from an outer side, in order to seal the orifice together with the liner. The exterior body presses the thin liner portion against the lower side portion of the flange and brings the thin liner portion in close contact therewith.

Abstract: An easily openable container lid has a shell and a liner embossed on the inner surface of a top panel wall and a pair of scores formed in the shell. The liner is adhered over the entire surface thereof to the inner surface of the top panel wall. At least second portions of the pair of scores are formed by forming grooves on the inner surface side of the shell, and are extended along the peripheral edge of the liner radially outwardly of the liner. Moreover, the liner has a thin-walled central section and a thick-walled peripheral edge section, and is configured to have a downwardly protruding outer sealing ridge formed in a radially outward region of the thick-walled peripheral edge section. The thickness of the thin-walled central section and the thickness of the thick-walled peripheral edge section are set within required ranges.

Abstract: There is provided a method by which multiple types of substances desired to be transferred into cells can be continuously transferred into multiple types of cells by a convenient procedure, a cell in which the substance desired to be transferred into cells has been taken up by this method, and an apparatus for transferring a substance into cells by this method. The foregoing objects can be achieved by electrospraying cells with a liquid free from the substance to be transferred into cells while the cells are kept in contact with the substance to be transferred into cells, or first electrospraying cells with a liquid free from the substance to be transferred into cells and then bringing the cells into contact with the substance to be transferred into cells.

Abstract: There is provided a method by which multiple types of substances desired to be transferred into cells can be continuously transferred into multiple types of cells by a convenient procedure, a cell in which the substance desired to be transferred into cells has been taken up by this method, and an apparatus for transferring a substance into cells by this method. The foregoing objects can be achieved by electrospraying cells with a liquid free from the substance to be transferred into cells while the cells are kept in contact with the substance to be transferred into cells, or first electrospraying cells with a liquid free from the substance to be transferred into cells and then bringing the cells into contact with the substance to be transferred into cells.