Abstract: The present invention has an object to develop and provide a target nucleic acid detection device having a low copy number of IPC nucleic acids placed therein, and a method for producing the device, to avoid a decrease caused in the detection sensitivity to a target nucleic acid through competitive inhibition of the target nucleic acid by addition of an internal positive control (IPC) nucleic acid. Provided is a target nucleic acid detection device in which a low copy number of IPC nucleic acids that do not inhibit the amplification reaction of a target nucleic acid is preliminarily placed in a reaction well.

Abstract: In one embodiment, provided are a method for analyzing at least one nucleic acid that can conveniently and highly accurately analyze even a very small number of analyte at least one nucleic acid. In one embodiment, the present invention relates to a method for analyzing at least one nucleic acid, comprising: a library preparation step of preparing a library comprising at least one standard nucleic acid of specific copy number(s) and at least one analyte nucleic acid in a same system; a calibration curve data generation step of generating calibration curve data based on the copy number(s) of the at least one standard nucleic acid of specific copy number(s); and an analyte nucleic acid analysis step of identifying at least one nucleotide sequence of the analyte nucleic acid while identifying the number(s) of the at least one nucleotide sequence of the at least one analyte nucleic acid using the calibration curve data.

Abstract: An information provision device includes an acquisition unit and an information output unit. The acquisition unit acquires test result data indicating a Cq value of a well obtained by a test device performing a polymerase chain reaction (PCR) test on a standard device having the well in which a known number of copies of a nucleic acid are disposed. The information output unit outputs comparison information obtained by comparing information obtained from evaluation target data that is the evaluation target data of an evaluation target with information obtained from one or more pieces of the test result data different from the evaluation target data.

Abstract: A sample for evaluating performance of a genetic testing apparatus includes, a nucleic acid A; and a nucleic acid B, in which the nucleic acid A and the nucleic acid B have mutually different sequences. The nucleic acid A contains a specific number of molecules, and the nucleic acid B contains a number of molecules higher than the number of molecules of the nucleic acid A. A ratio A/B of the number of molecules of the nucleic acid A with respect to the number of molecules of the nucleic acid B is specified.

Abstract: A power transmitting device includes a first rotor and a second rotor rotatably disposed coaxially with a rotational central axis and in facing relation to each other. A first pressing protrusion projecting from the first rotor and a second pressing protrusion projecting from the second rotor are disposed in relative positions on superposed rotation trajectories. A soft rubber member elastically deformable to a large extent and has a small modulus of elasticity and a hard rubber member elastically deformable to a small extent and has a large modulus of elasticity are interposed between the first and second pressing protrusions. While no relative torque load is being applied to the first and second rotors, the soft rubber member is held in contact with both the first and second pressing protrusions, and the hard rubber member is interposed between the first pressing protrusion and the second pressing protrusion with gaps therebetween.

Abstract: A power transmitting device includes a first rotor and a second rotor rotatably disposed coaxially with a rotational central axis and in facing relation to each other, a single arc spring that is elastically deformable to a large extent and has a small modulus of elasticity, the arc spring being interposed between the first rotor and the second rotor for urging the first rotor and the second rotor to opposite sides in a ration direction, a first pressing protrusion projecting from the first rotor and a second pressing protrusion projecting from the second rotor, the first pressing protrusion and the second pressing protrusion being disposed in relative positions on superposed rotation trajectories, and a rubber member that is elastically deformable to a small extent and has a large modulus of elasticity, the rubber member being interposed between the first pressing protrusion and the second pressing protrusion with gaps therebetween.

Abstract: Provided is a device including at least one well and an amplifiable reagent contained in a specific copy number in the at least one well. In a preferable mode, the device includes information on the specific copy number of the amplifiable reagent. In a more preferable mode, the device includes information on uncertainty as the information on the specific copy number, and the information on uncertainty includes a coefficient of variation CV of the amplifiable reagent, and the coefficient of variation CV satisfies a relational expression: CV<1/Vx, where x represents an average specific copy number of the amplifiable reagent. In a particularly preferable mode, the device includes a plurality of wells in which the amplifiable reagent is contained, and the amplifiable reagent is contained in each of the wells in the same specific copy number. The invention may use microscopes to verify the number of cells comprising the amplifiable reagent, i.e. nucleic acid, in each of the wells.

Abstract: Provided is a detection determining method used in detection of a testing target in a sample by amplification of the testing target and an amplifiable reagent, wherein the amplifiable reagent is provided in a number of 200 or less, the detection determining method including a determining step of determining that the testing target is present and a detection result is positive when the amplifiable reagent is amplified and the testing target is amplified, and determining that the testing target is absent or at least less than a specific copy number of the amplifiable reagent and a detection result is negative when the amplifiable reagent is amplified and the testing target is not amplified. Also provided are a detection determining device, a detection determining program, and a device used for the detection determining method.

Abstract: Provided is a device including: a plurality of wells; a reagent composition located in each of the wells and containing an amplifiable reagent in a specific copy number; and two or more groups into which the wells are divided to have the amplifiable reagent located in the same specific copy number but to be varied in composition of the reagent composition except for the specific copy number. Preferably, composition except for the specific copy number of the amplifiable reagent includes at least any one of primer and amplifying reagent. More preferably, the device includes two or more groups varied in the specific copy number. Yet more preferably, the groups of wells include at least a negative control group in which the specific copy number of the amplifiable reagent is 0, and a group in which the specific copy number of the amplifiable reagent is close to the limit of detection.

Abstract: Provided is a detection determining device used in a detection determining method including, in detection of a testing target in a sample by amplification of the testing target and an amplifiable reagent, determining that the testing target is present and a detection result is positive when the amplifiable reagent is amplified and the testing target is amplified, and determining that the testing target is absent or at least less than a specific copy number of the amplifiable reagent and a detection result is negative when the amplifiable reagent is amplified and the testing target is not amplified, the detection determining device including at least one well, wherein the amplifiable reagent in the at least one well is contained in a specific copy number.

Abstract: In one embodiment, provided are a method for analyzing at least one nucleic acid that can conveniently and highly accurately analyze even a very small number of analyte at least one nucleic acid. In one embodiment, the present invention relates to a method for analyzing at least one nucleic acid, comprising: a library preparation step of preparing a library comprising at least one standard nucleic acid of specific copy number(s) and at least one analyte nucleic acid in a same system; a calibration curve data generation step of generating calibration curve data based on the copy number(s) of the at least one standard nucleic acid of specific copy number(s); and an analyte nucleic acid analysis step of identifying at least one nucleotide sequence of the analyte nucleic acid while identifying the number(s) of the at least one nucleotide sequence of the at least one analyte nucleic acid using the calibration curve data.

Abstract: A power transmitting device includes a first rotor and a second rotor rotatably disposed coaxially with a rotational central axis and in facing relation to each other. A first pressing protrusion projecting from the first rotor and a second pressing protrusion projecting from the second rotor are disposed in relative positions on superposed rotation trajectories. A soft rubber member elastically deformable to a large extent and has a small modulus of elasticity and a hard rubber member elastically deformable to a small extent and has a large modulus of elasticity are interposed between the first and second pressing protrusions. While no relative torque load is being applied to the first and second rotors, the soft rubber member is held in contact with both the first and second pressing protrusions, and the hard rubber member is interposed between the first pressing protrusion and the second pressing protrusion with gaps therebetween.

Abstract: A power transmitting device includes a first rotor and a second rotor rotatably disposed coaxially with a rotational central axis be and in facing relation to each other, a single arc spring that is elastically deformable to a large extent and has a small modulus of elasticity, the arc spring being interposed between the first rotor and the second rotor for urging the first rotor and the second rotor to opposite sides in a ration direction, a first pressing protrusion projecting from the first rotor and a second pressing protrusion projecting from the second rotor, the first pressing protrusion and the second pressing protrusion being disposed in relative positions on superposed rotation trajectories, and a rubber member that is elastically deformable to a small extent and has a large modulus of elasticity, the rubber member being interposed between the first pressing protrusion and the second pressing protrusion with gaps therebetween.