Patents by Inventor Yusuke Sasano

Yusuke Sasano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of 20-nor-salvinorin A
    Patent number: 11512075
    Abstract: The invention provides 20-nor-salvinorin A, an analog of the kappa-opioid agonist salvinorin A. The 20-nor-salvinorin A is an active kappa-opioid modulator and can be used for treatment of medical conditions wherein modulation of the kappa-opioid receptor is medically indicated, such as pain, pruritis, depression, or inflammation, or conditions implicating perception and consciousness. 20-nor-salvinorin A can be less additive when used in treatment compared to a mu-opioid receptor agonist, and 20-nor-salvinorin A is more stable in vivo than is parent compound salvinorin A. The invention further provides synthetic intermediates and procedures for preparation of 20-nor-salvinorin A.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: November 29, 2022
    Assignee: The Scripps Research Institute
    Inventors: Ryan Shenvi, Jeremy Roach, Yusuke Sasano, Laura Bohn, Cullen Schmid
  • SYNTHESIS OF 20-NOR-SALVINORIN A
    Publication number: 20200131162
    Abstract: The invention provides 20-nor-salvinorin A, an analog of the kappa-opioid agonist salvinorin A. The 20-nor-salvinorin A is an active kappa-opioid modulator and can be used for treatment of medical conditions wherein modulation of the kappa-opioid receptor is medically indicated, such as pain, pruritis, depression, or inflammation, or conditions implicating perception and consciousness. 20-nor-salvinorin A can be less additive when used in treatment compared to a mu-opioid receptor agonist, and 20-nor-salvinorin A is more stable in vivo than is parent compound salvinorin A. The invention further provides synthetic intermediates and procedures for preparation of 20-nor-salvinorin A.
    Type: Application
    Filed: June 7, 2018
    Publication date: April 30, 2020
    Inventors: Ryan Shenvi, Jeremy Roach, Yusuke Sasano, Laura Bohn, Cullen Schmid
  • Method for producing 2-azaadamantane
    Patent number: 8669367
    Abstract: To provide a method whereby a 2-azaadamantane can easily be obtained in good yield. A method for producing a 2-azaadamantane represented by the formula (1), which comprises cyclizing a compound represented by the following formula (2) in the presence of an acid.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: March 11, 2014
    Assignees: Nissan Chemical Industries, Ltd., Tohoku Techno Arch Co., Ltd.
    Inventors: Toshimasa Hamada, Noriaki Nagahama, Masami Kozawa, Yoshiharu Iwabuchi, Masatoshi Shibuya, Masaki Tomizawa, Yusuke Sasano
  • METHOD FOR PRODUCING 2-AZAADAMANTANE
    Publication number: 20120310005
    Abstract: To provide a method whereby a 2-azaadamantane can easily be obtained in good yield. A method for producing a 2-azaadamantane represented by the formula (1), which comprises cyclizing a compound represented by the following formula (2) in the presence of an acid.
    Type: Application
    Filed: August 14, 2012
    Publication date: December 6, 2012
    Applicants: TOHOKU TECHNO ARCH CO., LTD., Nissan Chemical Industries, Ltd.
    Inventors: Toshimasa HAMADA, Noriaki NAGAHAMA, Masami KOZAWA, Yoshiharu IWABUCHI, Masatoshi SHIBUYA, Masaki TOMIZAWA, Yusuke SASANO
  • Method for producing 2-azaadamantane
    Patent number: 8273889
    Abstract: The invention provides a method for producing 2-azaadamantanes represented by formula (1) in good yields. The method includes cyclizing a compound represented by formula (2) in the presence of an acid.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: September 25, 2012
    Assignees: Nissan Chemical Industries, Ltd., Tohoku Techno Arch Co., Ltd.
    Inventors: Toshimasa Hamada, Noriaki Nagahama, Masami Kozawa, Yoshiharu Iwabuchi, Masatoshi Shibuya, Masaki Tomizawa, Yusuke Sasano
  • METHOD FOR PRODUCING 2-AZAADAMANTANE
    Publication number: 20100311977
    Abstract: To provide a method whereby a 2-azaadamantane can easily be obtained in good yield. A method for producing a 2-azaadamantane represented by the formula (1), which comprises cyclizing a compound represented by the following formula (2) in the presence of an acid.
    Type: Application
    Filed: November 20, 2008
    Publication date: December 9, 2010
    Applicants: Nissan Chemical Industries, Ltd., Tohoku Techno Arch Co., Ltd.
    Inventors: Toshimasa Hamada, Noriaki Nagahama, Masami Kozawa, Yoshiharu Iwabuchi, Masatoshi Shibuya, Masaki Tomizawa, Yusuke Sasano