Abstract: To reduce the burden on a user, and promote the purchase of insurance or other equivalent services. A management server 10, which is connected to a user terminal 20 used by a user, an insurer's terminal 30 used by an insurer, and a sponsor's terminal 40 used by a sponsor through a communication network, receives information about insurance products from the insurer's terminal 30, receives information about purchase conditions of the insurance products from the sponsor 'terminal 40, and determines whether to permit the user to purchase the service by at least partially referring to the purchase conditions received from the sponsor's terminal 40, when an application for the service purchase is received from the user terminal 20.

Abstract: To provide a card settlement method for short-term products which is easy to use for both participating merchants and card users. In providing a product billed by unit time to a user, a management server 100 requests payment of the billed amount to a card company server 300 via a network. The management server 100 accepts product selection information from the user and performs a credit check with the card company server 300 for the amount corresponding to a prescribed time period comprising more than one unit of the billable unit time associated with the product selected by the user. After credit is secured for the amount corresponding to the prescribed time period, the management server 100 derives a billable period wherein the user requested to be billed during the provision period of the product, and makes a request to the card company server 300 for a single payment in full for an amount corresponding to the billable period.

Abstract: To digitally manage product warranty periods and to prompt a user to sell a used product. Provided is a management server 100 comprising: a product table 121 which, for each user, stores information relating to a product possessed the user and a warranty period for said product; and a secondhand trader table 124 which, for each secondhand trader, stores information relating to a product for which the secondhand trader is able to compute a purchase price. Information is extracted from the product table 121 which relates to a product that has reached the end of the warranty period or has reached a predetermined time before expiry of the warranty period or a predetermined time after same. The terminal 400 of a secondhand trader being able to compute a purchase price for the product is notified of information relating to the product that has been extracted from the product table 121.

Abstract: The present disclosure describes compositions and methods for increasing the abundance of commensal bacteria belonging to the order Clostridiales, including Blautia, Ruminococcus, Clostridium, Eubacterium, Holdemania and Dorea species, that are associated with reduced lethal GVHD and improved overall survival following bone marrow or hematopoietic stem cell transplant. The present disclosure, therefore, provides methods for reducing the likelihood, incidence or severity of GVHD by (1) avoiding the loss of endogenous beneficial species through antibiotic selection; (2) by administering a therapeutically effective amount of a composition comprising one or more Clostridiales associated with reduced GVHD to individuals who may lack or have lost those strains from their intestinal microbiota.

Abstract: The object of the invention is to provide an immunological reconstitution promoter or a prophylactic agent for infections for use in allogeneic hematopoietic stem cell transplantation therapy for tumors. The promoter or prophylactic agent enables the amelioration of delayed immune reconstitution or the prevention of infection following transplantation, while maintaining the GVT effect of allogeneic hematopoietic stem cell transplantation. Specifically, in a transplant patient in whom immune reconstitution is delayed, such reconstitution can be promoted by administering, at an early stage following transplantation, a substance capable of depleting CD4+ cells. Early completion of infection management in the patient and improvement in the survival rate are anticipated as a result. In addition, the risk of complications associated with allogeneic hematopoietic stem cell transplantation is reduced, enabling more widespread use of this therapy.

Abstract: The object of the invention is to provide an immunological reconstitution promoter or a prophylactic agent for infections for use in allogeneic hematopoietic stem cell transplantation therapy for tumors. The promoter or prophylactic agent enables the amelioration of delayed immune reconstitution or the prevention of infection following transplantation, while maintaining the GVT effect of allogeneic hematopoietic stem cell transplantation. Specifically, in a transplant patient in whom immune reconstitution is delayed, such reconstitution can be promoted by administering, at an early stage following transplantation, a substance capable of depleting CD4+ cells. Early completion of infection management in the patient and improvement in the survival rate are anticipated as a result. In addition, the risk of complications associated with allogeneic hematopoietic stem cell transplantation is reduced, enabling more widespread use of this therapy.