Abstract: Provided is an isolation and purification method for isolating and purifying extracellular vesicles. In the method for isolating and purifying extracellular vesicles from a solution containing the extracellular vesicles and unnecessary substances. The isolation and purification method is an adsorbent treatment method in which a solution containing the extracellular vesicles and unnecessary substances is brought into contact with an adsorbent to cause the adsorbent to adsorb and retain the unnecessary substances other than the extracellular vesicles. The adsorbent is a porous granular material having a pore, an interior of the pore being positively charged, and the adsorbent can adsorb and retain, in the interior of the pore, negatively charged unnecessary substances other than the extracellular vesicles.

Abstract: A port number file verification function assesses whether a port number file is present in an administrated machine side storage module. If not present in the administrated machine side storage module, or if present in the administrated machine side storage module and communication with a port number of an administration server which is recorded in the present port number file is not possible, a port number file acquisition directive function directs a file acquisition unit to acquire a port number file of the administration server, the file acquisition unit which receives the directive requests the port number file via the administration server and a well-known port, and a port number identification function identifies a port number of the administration server on the basis of the content of the port number file which is acquired by the request.