Patents by Inventor Yusuke Wataya
Yusuke Wataya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9289411Abstract: Provided is a novel anti-HCV agent including as an active ingredient a peroxide derivative represented by the general formula (I). In the general formula (I), C represents an alicyclic hydrocarbon ring group which may be substituted, n represents an integer of from 1 to 6, and R represents a hydrogen atom or a hydroxyalkyl group. The peroxide derivative exhibits potent anti-HCV activity by remarkably suppressing HCV-RNA replication.Type: GrantFiled: October 2, 2012Date of Patent: March 22, 2016Assignee: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITYInventors: Nobuyuki Kato, Masanori Ikeda, Yusuke Wataya, Hye-Sook Kim, Hiroyuki Doi
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Patent number: 8927596Abstract: An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent development of liver dysfunction due to eggs of the schistosomes in the case of infection with the schistosomes. The novel antischistosomal agent includes as an active ingredient a peroxide derivative. Specifically, the novel antischistosomal agent includes as an active ingredient a peroxide derivative represented by the general formula (I): where C represents an alicyclic hydrocarbon ring group which may be substituted, and n represents an integer of 1 to 6.Type: GrantFiled: April 26, 2013Date of Patent: January 6, 2015Assignee: National University Corporation Okayama UniversityInventors: Yusuke Wataya, Hye-Sook Kim, Akiko Hiramoto, Akira Sato, Nobuo Ota, Takashi Kumagai, Rieko Shimogawara, Toshie Taniguchi
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Publication number: 20140242030Abstract: Provided is a novel anti-HCV agent including as an active ingredient a peroxide derivative represented by the general formula (I). In the general formula (I), C represents an alicyclic hydrocarbon ring group which may be substituted, n represents an integer of from 1 to 6, and R represents a hydrogen atom or a hydroxyalkyl group. The peroxide derivative exhibits potent anti-HCV activity by remarkably suppressing HCV-RNA replication.Type: ApplicationFiled: October 2, 2012Publication date: August 28, 2014Applicant: National University Corporation Okayama UniversityInventors: Nobuyuki Kato, Masanori Ikeda, Yusuke Wataya, Hye-Sook Kim, Hiroyuki Doi
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Publication number: 20130245108Abstract: An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent development of liver dysfunction due to eggs of the schistosomes in the case of infection with the schistosomes. The novel antischistosomal agent includes as an active ingredient a peroxide derivative. Specifically, the novel antischistosomal agent includes as an active ingredient a peroxide derivative represented by the general formula (I): where C represents an alicyclic hydrocarbon ring group which may be substituted, and n represents an integer of 1 to 6.Type: ApplicationFiled: April 26, 2013Publication date: September 19, 2013Applicant: National University Corporation Okayama UniversityInventors: Yusuke Wataya, Hye-Sook Kim, Akiko Hiramoto, Akira Sato, Nobuo Ota, Takashi Kumagai, Rieko Shimogawara, Toshie Taniguchi
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Publication number: 20110275668Abstract: Compounds with high antimalarial activity; and antimalarial drugs containing the same as an active ingredient. There are provided compounds with antimalarial activity represented by the chemical formula: (wherein R1 is H, Cl or OCH3; R2 is H or CH3; R3 is CH, CH2, C(CH3), CH(CH3) or C(CH3)2; Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan, thiophene or derivatives thereof; n is 1 to 5; and m is 1 to 5). Further, there are provided antimalarial drugs containing these compounds with antimalarial activity or pharmacologically acceptable salts thereof as active ingredients.Type: ApplicationFiled: May 16, 2011Publication date: November 10, 2011Applicant: Nagoya City UniversityInventors: Tsunehiko Higuchi, Hirohisa Omiya, Naoki Umezawa, Hye-Sook Kim, Yusuke Wataya
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Publication number: 20110172445Abstract: An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent development of liver dysfunction due to eggs of the schistosomes in the case of infection with the schistosomes. The novel antischistosomal agent includes as an active ingredient a peroxide derivative. Specifically, the novel antischistosomal agent includes as an active ingredient a peroxide derivative represented by the general formula (I): where C represents an alicyclic hydrocarbon ring group which may be substituted, and n represents an integer of 1 to 6.Type: ApplicationFiled: June 26, 2009Publication date: July 14, 2011Applicant: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITYInventors: Yusuke Wataya, Hye-Sook Kim, Akiko Hiramoto, Akira Sato, Nobuo Ota, Takashi Kumagai, Rieko Shimogawara, Toshie Taniguchi
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Patent number: 7973027Abstract: Compounds with high antimalarial activity; and antimalarial drugs containing the same as an active ingredient. There are provided compounds with antimalarial activity represented by the chemical formula: (wherein R1 is H, Cl or OCH3; R2 is H or CH3; R3 is CH, CH2, C(CH3), CH(CH3) or C(CH3)2; Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan, thiophene or derivatives thereof; n is 1 to 5; and m is 1 to 5). Further, there are provided antimalarial drugs containing these compounds with antimalarial activity or pharmacologically acceptable salts thereof as active ingredients.Type: GrantFiled: February 26, 2007Date of Patent: July 5, 2011Assignee: Nagoya City UniversityInventors: Tsunehiko Higuchi, Hirohisa Omiya, Naoki Umezawa, Hye-Sook Kim, Yusuke Wataya
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Publication number: 20090275612Abstract: Compounds with high antimalarial activity; and antimalarial drugs containing the same as an active ingredient. There are provided compounds with antimalarial activity represented by the chemical formula: (wherein R1 is H, Cl or OCH3; R2 is H or CH3; R3 is CH, CH2, C(CH3), CH(CH3) or C(CH3)2; Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan, thiophene or derivatives thereof; n is 1 to 5; and m is 1 to 5). Further, there are provided antimalarial drugs containing these compounds with antimalarial activity or pharmacologically acceptable salts thereof as active ingredients.Type: ApplicationFiled: February 26, 2007Publication date: November 5, 2009Applicant: Nagoya City UniversityInventors: Tsunehiko Higuchi, Hirohisa Omiya, Naoki Umezawa, Hye-Sook Kim, Yusuke Wataya
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Patent number: 7407984Abstract: The present invention is to provide an antimalarial agent having excellent antimalarial activity with little side effects, in particular, having remarkable antimalarial activity against drug-resistant malaria parasites, and being capable of increasing solubility not only to organic solvent including olive oil, but also to water, and therefore, being usable not only as oral drugs but also as injectable solutions. The antimalarial agent of the present invention contains a compound represented by the following general formula (I) [wherein Z represents an unsubstituted or optionally substituted alicyclic hydrocarbon group, R0 represents a water-soluble functional group, m represents any one of integers of from 0 to 6, n represents any one of integers of from 0 to 10.].Type: GrantFiled: March 11, 2003Date of Patent: August 5, 2008Assignee: Okayama UniversityInventors: Yusuke Wataya, Hye-Sook Kim, Masatomo Nojima
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Patent number: 6939892Abstract: An antibiotic SF2487 substance having the formula (I) or a salt thereof possesses an antimalarial activity against the proliferation of malarial parasites and is therefore useful as an antimalarial drug.Type: GrantFiled: April 26, 2001Date of Patent: September 6, 2005Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Yusuke Wataya, Munekazu Iinuma, Hye-Sook Kim, Hiroomi Watabe, Hiroshi Naganawa, Yoshikazu Takahashi
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Publication number: 20050131058Abstract: The present invention is to provide an antimalarial agent having excellent antimalarial activity with little side effects, in particular, having remarkable antimalarial activity against drug-resistant malaria parasites, and being capable of increasing solubility not only to organic solvent including olive oil, but also to water, and therefore, being usable not only as oral drugs but also as injectable solutions. The antimalarial agent of the present invention contains a compound represented by the following general formula (I) [wherein Z represents an unsubstituted or optionally substituted alicyclic hydrocarbon group, R0 represents a water-soluble functional group, m represents anyone of integers of from 0 to 6, n represents any one of integers of from 0 to 10.].Type: ApplicationFiled: March 11, 2003Publication date: June 16, 2005Inventors: Yusuke Wataya, Hye-Sook Kim, Masatomo Nojima
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Patent number: 6844350Abstract: A febrifugine represented by Formula (A): and an isofebrifugine represented by Formula (B): which exhibit extremely strong activities against tropical malarial protozoan are provided, together with a total synthesis route which enables efficient large scale synthesis of the same.Type: GrantFiled: July 3, 2002Date of Patent: January 18, 2005Assignee: Japan Science and Technology CorporationInventors: Shu Kobayashi, Yusuke Wataya, Hye-Sook Kim
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Patent number: 6710074Abstract: An object of the present invention is to provide a novel compound having antimalarial acitivity and an antimalarial agent containing the novel compound as an active component. An antimalarial agent containing 12-hidroxy-2-(1-methoxy-carbonylethyl)-5-oxo-10,11,13-trioxatricyclo[7.2.0.01,6]tridecane represented by a following formula (II) as an active agent is prepared.Type: GrantFiled: August 30, 2002Date of Patent: March 23, 2004Assignee: Japan Science and Technology CorporationInventors: Masataka Ihara, Kiyosei Takasu, Yusuke Wataya, Hye-Sook Kim
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Publication number: 20030176492Abstract: An antibiotic SF2487 substance having the formula (I) 1Type: ApplicationFiled: January 27, 2003Publication date: September 18, 2003Inventors: Tomio Takeuchi, Yusuke Wataya, Munekazu Iinuma, Hye-Sook Kim, Hiroomi Watabe, Hiroshi Naganawa, Yoshikazu Takahashi
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Publication number: 20030078291Abstract: An object of the present invention is to provide a novel compound having antimalarial acitivity and an antimalarial agent containing the novel compound as an active component. An antimalarial agent containing 12-hidroxy-2-(1-methoxy-carbonylethyl)-5-oxo-10,11,13-trioxatricyclo[7.2.0.01,6]tridecane represented by a following formula (II) as an active agent is prepared.Type: ApplicationFiled: August 30, 2002Publication date: April 24, 2003Inventors: Masataka Ihara, Kiyosei Takasu, Yusuke Wataya, Hye-Sook Kim
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Publication number: 20020193387Abstract: A febrifugine represented by Formula (A): 1Type: ApplicationFiled: July 3, 2002Publication date: December 19, 2002Inventors: Shu Kobayashi, Yusuke Wataya, Hye-Sook Kim
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Patent number: 6420372Abstract: A febrifugine represented by Formula (A): and an isofebrifugine represented by Formula (B): which exhibit extremely strong activities against tropical malarial protozoan are provided, together with a total synthesis route which enables efficient large scale synthesis of the same.Type: GrantFiled: December 22, 2000Date of Patent: July 16, 2002Assignee: Japan Science and Technology CorporationInventors: Shu Kobayashi, Yusuke Wataya, Hye-Sook Kim
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Patent number: 5792609Abstract: A method of detecting falciparum, tertian, quartan and ovale malaria parasites by using primers represented by the sequences (SEQ ID NO:1), (SEQ ID NO:3) to (SEQ ID NO:10):5'AAGTCATCTTTCGAGGTGAC3' (SEQ ID NO:4)5'GAATTTTCTCTTCGGAGTTTA3' (SEQ ID NO:5)5'GAGACATTCTTATATATG3' (SEQ ID NO:3)5'GAAAATTCCTTTCGGGGA3' (SEQ ID NO:1)5'CGACTAGGTGTTGGATGA3' (SEQ ID NO:6)5'GAACGAAAGTTAAGGGAGT3' (SEQ ID NO:7)5'ACTGAAGGAAGCAATCTAA3' (SEQ ID NO:8)5'TCAGATACCGTCGTAATCTT3' (SEQ ID NO:9)5'CCAAAGACTTTGATTTCTCAT3' (SEQ ID NO:10)This invention allows all of the plasmodia, which infect the human, to be detected easily, rapidly and with a high sensitivity or distinguished accurately from one another, thus permitting treatment for malaria and large-scale mass examination in the area where malaria is prevalent.Type: GrantFiled: September 11, 1995Date of Patent: August 11, 1998Assignee: Wakunaga Pharmaceutical Co., Ltd.Inventors: Yusuke Wataya, Akio Yamane