Patents by Inventor Yusuke Yamagishi
Yusuke Yamagishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11891457Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.Type: GrantFiled: September 3, 2020Date of Patent: February 6, 2024Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
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Patent number: 11435201Abstract: An information processing system and an information processing device that are capable of reflecting an emotion of a user and performing route search. In an information processing system including a search unit that performs the route search on the basis of route search information that is input, to output a result searched by the search unit, the search unit performs the route search on the basis of the route search information, and emotion information obtained from an artificial intelligence module that generates an emotion of the same quality as in an emotion of a searcher.Type: GrantFiled: December 28, 2016Date of Patent: September 6, 2022Assignee: HONDA MOTOR CO., LTD.Inventors: Yusuke Yamagishi, Kazuhiro Ito, Yoji Motegi, Susumu Saito, Shinji Kawasaki
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Publication number: 20220125891Abstract: The present invention found that, for example, inhibiting phosphorylation of a Ser residue in Regnase-1 is effective in treating and/or preventing diseases. The invention also found that, for example, inhibiting the binding of Regnase-1 with at least one factor selected from the group consisting of TBK1, IKKi, Act-1, IKK, and IRAK is effective in treating and/or preventing diseases.Type: ApplicationFiled: June 6, 2019Publication date: April 28, 2022Inventors: Shizuo AKIRA, Takashi SATOH, Hiroki TANAKA, Keiko SAITO, Yusuke YAMAGISHI
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Publication number: 20210087572Abstract: The present invention provides modified aminoacyl-tRNA synthetases (ARSs) having increased reactivity with N-methyl amino acids compared to natural aminoacyl-tRNA synthetases. The modified aminoacyl-tRNA synthetases according to the present invention can aminoacylate tRNAs with their corresponding N-methyl-substituted amino acids such as N-methyl-phenylalanine, N-methyl-valine, N-methyl-serine, N-methyl-threonine, N-methyl-tryptophan and N-methyl-leucine more efficiently than natural aminoacyl-tRNA synthetases. The present invention enables a more efficient production of polypeptides containing N-methyl amino acids.Type: ApplicationFiled: September 18, 2020Publication date: March 25, 2021Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Atsushi OHTA, Yusuke YAMAGISHI, Atsushi MATSUO
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Publication number: 20210061860Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.Type: ApplicationFiled: September 3, 2020Publication date: March 4, 2021Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Shiori KARIYUKI, Takeo Ilda, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Ilkura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
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Patent number: 10815489Abstract: The present invention provides modified aminoacyl-tRNA synthetases (ARSs) having increased reactivity with N-methyl amino acids compared to natural aminoacyl-tRNA synthetases. The modified aminoacyl-tRNA synthetases according to the present invention can aminoacylate tRNAs with their corresponding N-methyl-substituted amino acids such as N-methyl-phenylalanine, N-methyl-valine, N-methyl-serine, N-methyl-threonine, N-methyl-tryptophan, and N-methyl-leucine more efficiently than natural aminoacyl-tRNA synthetases. The present invention enables a more efficient production of polypeptides containing N-methyl amino acids.Type: GrantFiled: March 11, 2016Date of Patent: October 27, 2020Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Atsushi Ohta, Yusuke Yamagishi, Atsushi Matsuo
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Patent number: 10688736Abstract: A method of molding composite materials including shaping a laminate having fiber sheets laminated over one another, by bending the laminate in an X-direction and a Y-direction, in a three-dimensional orthogonal coordinate system. The method further includes mounting the laminate that has been shaped, onto a mold material deformed in a Z-direction, impregnating a resin material into the laminate while adjusting an amount of the resin material filled in, and molding the composite materials that have cured such that the composite materials are shaped to have a first inclined surface inclined at a first inclination angle with respect to a reference plane in the Z-direction. The mold material has a first inclination molding surface that molds the first inclined surface, and a second inclination molding surface that molds a surface of the composite materials into a second inclined surface having a second inclination angle smaller than the first inclination angle.Type: GrantFiled: December 2, 2016Date of Patent: June 23, 2020Assignees: MITSUBISHI HEAVY INDUSTRIES, LTD., TORAY INDUSTRIES, INC.Inventors: Kodai Shimono, Hiroshi Tokutomi, Kensuke Kokumai, Yusuke Yamagishi
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Publication number: 20200191590Abstract: An information processing system and an information processing device that are capable of reflecting an emotion of a user and performing route search. In an information processing system including a search unit that performs the route search on the basis of route search information that is input, to output a result searched by the search unit, the search unit performs the route search on the basis of the route search information, and emotion information obtained from an artificial intelligence module that generates an emotion of the same quality as in an emotion of a searcher.Type: ApplicationFiled: December 28, 2016Publication date: June 18, 2020Inventors: Yusuke Yamagishi, Kazuhiro Ito, Yoji Motegi, Susumu Saito, Shinji Kawasaki
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Publication number: 20180257317Abstract: A method of molding composite materials including shaping a laminate having fiber sheets laminated over one another, by bending the laminate in an X-direction and a Y-direction, in a three-dimensional orthogonal coordinate system. The method further includes mounting the laminate that has been shaped, onto a mold material deformed in a Z-direction, impregnating a resin material into the laminate while adjusting an amount of the resin material filled in, and molding the composite materials that have cured such that the composite materials are shaped to have a first inclined surface inclined at a first inclination angle with respect to a reference plane in the Z-direction. The mold material has a first inclination molding surface that molds the first inclined surface, and a second inclination molding surface that molds a surface of the composite materials into a second inclined surface having a second inclination angle smaller than the first inclination angle.Type: ApplicationFiled: December 2, 2016Publication date: September 13, 2018Inventors: Kodai SHIMONO, Hiroshi TOKUTOMI, Kensuke KOKUMAI, Yusuke YAMAGISHI
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Publication number: 20180127761Abstract: The present invention provides modified aminoacyl-tRNA synthetases (ARSs) having increased reactivity with N-methyl amino acids compared to natural aminoacyl-tRNA synthetases. The modified aminoacyl-tRNA synthetases according to the present invention can aminoacylate tRNAs with their corresponding N-methyl-substituted amino acids such as N-methyl-phenylalanine, N-methyl-valine, N-methyl-serine, N-methyl-threonine, N-methyl-tryptophan, and N-methyl-leucine more efficiently than natural aminoacyl-tRNA synthetases. The present invention enables a more efficient production of polypeptides containing N-methyl amino acids.Type: ApplicationFiled: March 11, 2016Publication date: May 10, 2018Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Atsushi OHTA, Yusuke YAMAGISHI, Atsushi MATSUO
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Publication number: 20160311858Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.Type: ApplicationFiled: May 27, 2016Publication date: October 27, 2016Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
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Patent number: 9409952Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.Type: GrantFiled: December 28, 2012Date of Patent: August 9, 2016Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
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Patent number: 9410148Abstract: A method for screening a non-standard peptide compound in the peptide library that binds to the target substance, comprising the steps: (i) preparing a non-standard peptide library wherein a special (non-standard) amino acid is randomly incorporated into the peptide sequence by a cell-free (in vitro) translation system comprising a tRNA acylated by a special (non-standard) amino acid; (ii) bringing the obtained peptide library in contact with a target substance; and (iii) selecting a non-standard peptide that binds to the target substance as an active peptide.Type: GrantFiled: September 8, 2011Date of Patent: August 9, 2016Assignee: THE UNIVERSITY OF TOKYOInventors: Hiroaki Suga, Yusuke Yamagishi
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Patent number: 9090668Abstract: The objective is to provide a novel process for synthesizing a cyclic peptide compound. It is also an objective to provide a novel cyclic peptide compound. The novel process for synthesizing a cyclic peptide compound comprises the steps of: (1) translationally synthesizing a non-cyclic peptide compound having in a molecule a functional group 1 and a functional group 2, which are a pair of functional groups capable of reacting to form a bond, and (2) cyclizing the non-cyclic peptide compound by the reaction of the functional groups 1 and 2 to form a bond. The novel cyclic peptide compound can be synthesized by the process.Type: GrantFiled: March 26, 2008Date of Patent: July 28, 2015Assignee: THE UNIVERSITY OF TOKYOInventors: Hiroaki Suga, Hiroshi Murakami, Yuki Goto, Yusuke Yamagishi, Hiroshi Ashigai, Yusuke Sako
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Publication number: 20150080549Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.Type: ApplicationFiled: December 28, 2012Publication date: March 19, 2015Inventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
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Publication number: 20130178394Abstract: A method for screening a non-standard peptide compound in the peptide library that binds to the target substance, comprising the steps: (i) preparing a non-standard peptide library wherein a special (non-standard) amino acid is randomly incorporated into the peptide sequence by a cell-free (in vitro) translation system comprising a tRNA acylated by a special (non-standard) amino acid; (ii) bringing the obtained peptide library in contact with a target substance; and (iii) selecting a non-standard peptide that binds to the target substance as an active peptide.Type: ApplicationFiled: September 8, 2011Publication date: July 11, 2013Applicant: THE UNIVERSITY OF TOKYOInventors: Hiroaki Suga, Yusuke Yamagishi
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Publication number: 20100168380Abstract: The objective is to provide a novel process for synthesizing a cyclic peptide compound. It is also an objective to provide a novel cyclic peptide compound. The novel process for synthesizing a cyclic peptide compound comprises the steps of: (1) translationally synthesizing a non-cyclic peptide compound having in a molecule a functional group 1 and a functional group 2, which are a pair of functional groups capable of reacting to form a bond, and (2) cyclizing the non-cyclic peptide compound by the reaction of the functional groups 1 and 2 to form a bond. The novel cyclic peptide compound can be synthesized by the process.Type: ApplicationFiled: March 26, 2008Publication date: July 1, 2010Applicant: THE UNIVERSITY OF TOKYOInventors: Hiroaki Suga, Hiroshi Murakami, Yuki Goto, Yusuke Yamagishi, Hiroshi Ashigai, Yusuke Sako