Abstract: The disclosure relates to immune cells comprising a dual receptor system responsive to loss of heterozygosity in a target cell, and methods of making and using same. The first receptor comprises activator receptor specific to an HLA-E antigen, and the second receptor comprises an inhibitory receptor specific to an antigen lost in cancer but not wild type cells, that inhibits activation of the immune cells by the first receptor.

Abstract: The disclosure relates to immune cells comprising a dual receptor system responsive to loss of heterozygosity in a target cell, and methods of making and using same. The first receptor comprises activator receptor specific to a HER2 antigen, and the second receptor comprises an inhibitory receptor specific to an antigen lost in cancer but not wild type cells, that inhibits activation of the immune cells by the first receptor.

Abstract: In a method in which inside a vacuum chamber, a silicon target and a to-be-deposited object are disposed in a positional relationship to face each other; a sputtering gas, containing therein nitrogen gas, is introduced into the vacuum chamber which is in a vacuum atmosphere; a negative potential is applied to the silicon target such that a silicon nitride film having a tensile stress is deposited in a reactive sputtering on a surface of the to-be-deposited object that is placed in an electrically floated state. The method includes steps: in which the to-be-deposited object is made to a state in which a bias potential is free from being applied thereto; and at least one of a flow ratio of the nitrogen gas to the sputtering gas, and the potential to be applied to the silicon target is controlled such that the surface of the silicon target can be maintained in a transition mode.

Abstract: The disclosure relates to immune cells comprising a dual receptor system responsive to loss of heterozygosity in a target cell, and methods of making and using same. The first receptor comprises activator receptor specific to a HER2 antigen, and the second receptor comprises an inhibitory receptor specific to an antigen lost in cancer but not wild type cells, that inhibits activation of the immune cells by the first receptor.

Abstract: The disclosure relates to immune cells comprising a dual receptor system responsive to loss of heterozygosity in a target cell, and methods of making and using same. The first receptor comprises activator receptor specific to a HER2 antigen, and the second receptor comprises an inhibitory receptor specific to an antigen lost in cancer but not wild type cells, that inhibits activation of the immune cells by the first receptor.

Abstract: To support information sharing between terminals existing within a short distance from each other while a burden on a server administrator is prevented from increasing or decreased. An information sharing support server includes a server data transmission and reception control unit which recognizes identifiers of sending terminals associated with identifiers of originating terminals (STEP 446, STEP 466), recognizes identifiers of terminals associated with the relevant identifiers of the sending terminals (STEP 448, STEP 450, STEP 468), and transmits data to the relevant terminals (STEP 452, STEP 470).

Abstract: Hypoxia plays a central role in cancer progression and resistance to therapy. A microdevice platform is engineered to recapitulate the intratumor oxygen gradients that drive the heterogeneous hypoxic landscapes in solid tumors. The microdevice design features a “tumor section”-like culture by incorporating a cell layer between two diffusion barriers, where an oxygen gradient is established by cellular metabolism and physical constraints. The oxygen gradient is confirmed by numerical simulation and imaging-based oxygen sensor measurement. Spatially-resolved hypoxic signaling in cancer cells is also demonstrated through immunostaining, gene expression assay, and hypoxia-targeted drug treatment. The microdevice platform can accurately generate and control oxygen gradients, eliminates complex microfluidic handling, allows for incorporation of additional tumor components, and is compatible with high-content imaging and high-throughput applications.

Abstract: Hypoxia plays a central role in cancer progression and resistance to therapy. A microdevice platform is engineered to recapitulate the intratumor oxygen gradients that drive the heterogeneous hypoxic landscapes in solid tumors. The microdevice design features a “tumor section”-like culture by incorporating a cell layer between two diffusion barriers, where an oxygen gradient is established by cellular metabolism and physical constraints. The oxygen gradient is confirmed by numerical simulation and imaging-based oxygen sensor measurement. Spatially-resolved hypoxic signaling in cancer cells is also demonstrated through immunostaining, gene expression assay, and hypoxia-targeted drug treatment. The microdevice platform can accurately generate and control oxygen gradients, eliminates complex microfluidic handling, allows for incorporation of additional tumor components, and is compatible with high-content imaging and high-throughput applications.

Abstract: To support information sharing between terminals existing within a short distance from each other while a burden on a server administrator is prevented from increasing or decreased. An information sharing support server includes a server data transmission and reception control unit which recognizes identifiers of sending terminals associated with identifiers of originating terminals (STEP 446, STEP 466), recognizes identifiers of terminals associated with the relevant identifiers of the sending terminals (STEP 448, STEP 450, STEP 468), and transmits data to the relevant terminals (STEP 452, STEP 470).

Abstract: Hypoxia plays a central role in cancer progression and resistance to therapy. A microdevice platform is engineered to recapitulate the intratumor oxygen gradients that drive the heterogeneous hypoxic landscapes in solid tumors. The microdevice design features a “tumor section”-like culture by incorporating a cell layer between two diffusion barriers, where an oxygen gradient is established by cellular metabolism and physical constraints. The oxygen gradient is confirmed by numerical simulation and imaging-based oxygen sensor measurement. Spatially-resolved hypoxic signaling in cancer cells is also demonstrated through immunostaining, gene expression assay, and hypoxia-targeted drug treatment. The microdevice platform can accurately generate and control oxygen gradients, eliminates complex microfluidic handling, allows for incorporation of additional tumor components, and is compatible with high-content imaging and high-throughput applications.

Abstract: Provided is a method for a portable terminal to acquire Web site pages related to the current position, without a user selecting a site page. A proxy server includes an address correspondence table in which the addresses of the site pages and access points are associated. The portable terminal searches for the access points in the vicinity, receives annunciation signals including access points' addresses, and measures the reception levels. The portable terminal transmits a page acquisition request to the proxy server. The proxy server searches for the address of the site page corresponding to the address of each access point, using address correspondence table, and transmits list information, where the addresses are arranged in descending order of reception levels, to the portable terminal. The portable terminal presents the list information to the user and transmits page acquisition requests having one or more addresses as destinations to the corresponding site servers.

Abstract: Provided is a method for exchanging messages only between the users in a predetermined range around the current position, without intentionally grouping the users. A message server stores a message table where a message is associated with each set of addresses of a plurality of access points. A portable terminal searches for access points near the portable terminal and receives annunciation signal including the address of the access point from each access point. The portable terminal transmits, to a message server, a message acquisition request including, as a query, the set of the addresses included in the annunciation signals. The message server compares the set of the addresses as the query with a plurality of sets of addresses recorded in the message table, extracts messages corresponding to the sets of the addresses ranking high arranged in descending order of similarity, and transmits the messages to the portable terminal.

Abstract: A line card monitors communicability between itself and first to third fabric cards, and when there is abnormality in the communicability with the second fabric card, detects the abnormality and configures settings to switch a frame transmitted to the second fabric card so as to be directed to the third fabric card as a result of the detection of the abnormality within a first period. A communicability test unit generates a test frame at every second period, transmits the test frame to the fabric card selected by a path selection unit, and receives the test frame returned from the fabric card. The second period is longer than the first period, and the communicability test unit evaluates the presence or absence of a fault based on the reception results for the first and second test frames.

Abstract: Provided is a method for exchanging messages only between the users in a predetermined range around the current position, without intentionally grouping the users. A message server stores a message table where a message is associated with each set of addresses of a plurality of access points. A portable terminal searches for access points near the portable terminal and receives annunciation signal including the address of the access point from each access point. The portable terminal transmits, to a message server, a message acquisition request including, as a query, the set of the addresses included in the annunciation signals. The message server compares the set of the addresses as the query with a plurality of sets of addresses recorded in the message table, extracts messages corresponding to the sets of the addresses ranking high arranged in descending order of similarity, and transmits the messages to the portable terminal.

Abstract: A proxy server includes an address correspondence table in which reference information is associated with each set of the address of the access point and the address of the site page. The portable terminal searches for the access points in the vicinity of the portable terminal, receives annunciation signals including the addresses of the access points, and transmits a page acquisition request including the addresses and query information to the proxy server. The proxy server searches for the addresses of the site pages, using the address correspondence table, and generates list information in which the addresses are arranged such that the address having the reference information related to the query information ranks high, and transmits the list information as a response to the portable terminal. It is preferable that the portable terminal transmit each page acquisition request based on the list information to site servers.

Abstract: Provided is a method for a portable terminal to acquire Web site pages related to the current position, without a user selecting a site page. A proxy server includes an address correspondence table in which the addresses of the site pages and access points are associated. The portable terminal searches for the access points in the vicinity, receives annunciation signals including access points' addresses, and measures the reception levels. The portable terminal transmits a page acquisition request to the proxy server. The proxy server searches for the address of the site page corresponding to the address of each access point, using address correspondence table, and transmits list information, where the addresses are arranged in descending order of reception levels, to the portable terminal. The portable terminal presents the list information to the user and transmits page acquisition requests having one or more addresses as destinations to the corresponding site servers.

Abstract: A line card monitors communicability between itself and first to third fabric cards, and when there is abnormality in the communicability with the second fabric card, detects the abnormality and configures settings to switch a frame transmitted to the second fabric card so as to be directed to the third fabric card as a result of the detection of the abnormality within a first period. A communicability test unit generates a test frame at every second period, transmits the test frame to the fabric card selected by a path selection unit, and receives the test frame returned from the fabric card. The second period is longer than the first period, and the communicability test unit evaluates the presence or absence of a fault based on the reception results for the first and second test frames.