Patents by Inventor Yuta TEZUKA

Yuta TEZUKA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BISPECIFIC ANTIBODY BINDING TO CD40 AND FAP
    Publication number: 20220259328
    Abstract: An object of the present invention is to provide a bispecific antibody, which binds to CD40 and FAP and exhibits a strong CD40 agonistic activity in a FAP dependent manner or a bispecific antibody fragment thereof, and the like. The present invention relates to a bispecific antibody, which is a bispecific antibody containing an IgG portion including a first antigen binding domain and also containing a second antigen binding domain, and binding to human CD40 and human FAP, wherein the C terminus of a heavy chain of the IgG portion binds to the second antigen binding domain either directly or via a linker, or a bispecific antibody fragment thereof, and the like.
    Type: Application
    Filed: May 15, 2020
    Publication date: August 18, 2022
    Applicant: Kyowa Kirin Co., Ltd.
    Inventors: Yuta TEZUKA, Aya OSANAI, Katsuaki USAMI, Harue NISHIYA
  • Heterodimer protein composition
    Patent number: 10494437
    Abstract: According to the present invention, a heterodimer protein composition that is composed of a first polypeptide comprising an immunoglobulin heavy chain constant region and a second polypeptide comprising CL-Fc prepared by fusion of an immunoglobulin light chain constant region (CL) and Fc region, and also has a deletion or substitution of Cys residues involved in disulfide bonds between CL and CH1, a purification method of the protein composition thereof, a preparation method of the protein composition thereof, a DNA and a vector encoding the protein composition thereof are provided.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: December 3, 2019
    Assignee: KYOWA KIRIN CO., LTD
    Inventors: Rinpei Niwa, Mami Tsuchiya, Takuya Murakami, Yuta Tezuka
  • HETERODIMER PROTEIN COMPOSITION
    Publication number: 20170362323
    Abstract: According to the present invention, a heterodimer protein composition that is composed of a first polypeptide comprising an immunoglobulin heavy chain constant region and a second polypeptide comprising CL-Fc prepared by fusion of an immunoglobulin light chain constant region (CL) and Fc region, and also has a deletion or substitution of Cys residues involved in disulfide bonds between CL and CH1, a purification method of the protein composition thereof, a preparation method of the protein composition thereof, a DNA and a vector encoding the protein composition thereof are provided
    Type: Application
    Filed: June 15, 2017
    Publication date: December 21, 2017
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Rinpei NIWA, Mami TSUCHIYA, Takuya MURAKAMI, Yuta TEZUKA
  • Heterodimer protein composition
    Patent number: 9714291
    Abstract: According to the present invention, a heterodimer protein composition that is composed of a first polypeptide comprising an immunoglobulin heavy chain constant region and a second polypeptide comprising CL-Fc prepared by fusion of an immunoglobulin light chain constant region (CL) and Fc region, and also has a deletion or substitution of Cys residues involved in disulfide bonds between CL and CH1, a purification method of the protein composition thereof, a preparation method of the protein composition thereof, a DNA and a vector encoding the protein composition thereof are provided.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: July 25, 2017
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Rinpei Niwa, Mami Tsuchiya, Takuya Murakami, Yuta Tezuka
  • HETERODIMER PROTEIN COMPOSITION
    Publication number: 20140120581
    Abstract: According to the present invention, a heterodimer protein composition that is composed of a first polypeptide comprising an immunoglobulin heavy chain constant region and a second polypeptide comprising CL-Fc prepared by fusion of an immunoglobulin light chain constant region (CL) and Fc region, and also has a deletion or substitution of Cys residues involved in disulfide bonds between CL and CH1, a purification method of the protein composition thereof, a preparation method of the protein composition thereof, a DNA and a vector encoding the protein composition thereof are provided
    Type: Application
    Filed: October 4, 2013
    Publication date: May 1, 2014
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Rinpei NIWA, Mami TSUCHIYA, Takuya MURAKAMI, Yuta TEZUKA