Patents by Inventor Yutaka Ariki

Yutaka Ariki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxystyrene compounds having tyrosine kinase inhibiting activity
    Patent number: 5202341
    Abstract: A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.
    Type: Grant
    Filed: July 25, 1991
    Date of Patent: April 13, 1993
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Tadayoshi Shiraishi, Keiji Kameyama, Takeshi Domoto, Naohiro Imai, Yoshio Shimada, Yutaka Ariki, Kazunori Hosoe, Masaji Kawatsu, Ikuo Katsumi, Takayoshi Hidaka, Kiyoshi Watanabe
  • 1-phenyl-3,5-pyrazolidinedione hydroxystyrene compounds which have tyrosine kinase inhibiting activity
    Patent number: 5089516
    Abstract: A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.
    Type: Grant
    Filed: September 19, 1990
    Date of Patent: February 18, 1992
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Tadayoshi Shiraishi, Keiji Kameyama, Takeshi Domoto, Naohiro Imai, Yoshio Shimada, Yutaka Ariki, Kazunori Hosoe, Masaji Kawatsu, Ikuo Katsumi, Takayoshi Hidaka, Kiyoshi Watanabe
  • Hydroxystyrene compounds which have useful pharmaceutical utility
    Patent number: 5057538
    Abstract: A hydroxystyrene derivative represented by the formula (I): ##STR1## Wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sub.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O--(R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 --(Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: October 15, 1991
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Tadayoshi Shiraishi, Keiji Kameyama, Takeshi Domoto, Naohiro Imai, Yoshio Shimada, Yutaka Ariki, Kazunoro Hosoe, Masaji Kawatsu, Ikuo Katsumi, Takayoshi Hidaka, Kiyoshi Watanabe
  • Hydroxystyrene compounds which are useful as tyrosine kinase inhibitors
    Patent number: 4971996
    Abstract: A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.
    Type: Grant
    Filed: November 10, 1988
    Date of Patent: November 20, 1990
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Tadayoshi Shiraishi, Keiji Kameyama, Takeshi Domoto, Naohiro Imai, Yoshio Shimada, Yutaka Ariki, Kazunori Hosoe, Masaji Kawatsu, Ikuo Katsumi, Takayoshi Hidaka, Kiyoshi Watanabe
  • Anti-inflammatory, analgesic, and antipyretic pharmaceutical composition
    Patent number: 4440784
    Abstract: A new anti-inflammatory, analgesic, and antipyretic pharmaceutical composition is disclosed which contains a 3,5-di-tert-butyl-4-hydroxystyrene derivative of the formula: ##STR1## wherein R.sup.1 stands for a group represented by COR.sup.3 [R.sup.3 denotes a group of OR.sup.4 (R.sup.4 is a hydrogen atom or an alkyl group with C.sub.1 .about.C.sub.4), an alkyl group with C.sub.1 .about.C.sub.3, a phenyl group, or an amino group], a nitro group, or an alkylsulfonyl group represented by SO.sub.2 R.sup.5 (R.sup.5 is an alkyl group with C.sub.1 .about.C.sub.3); and R.sup.2 stands for a hydrogen atom, an alkyl group with C.sub.1 .about.C.sub.4, a hydroxyalkyl group with C.sub.1 .about.C.sub.4, a cyano group, or an acyl group represented by COR.sup.6 (R.sup.6 is an alkyl group with C.sub.1 .about.C.sub.3),or its pharmaceutically acceptable salt as an active ingredient in association with pharmaceutical excipients.
    Type: Grant
    Filed: January 5, 1982
    Date of Patent: April 3, 1984
    Assignee: Kanegafuchi Chemical Industry Company, Ltd.
    Inventors: Ikuo Katsumi, Hideo Kondo, Katsuji Yamashita, Takayoshi Hidaka, Kazunori Hosoe, Yutaka Ariki, Toshiaki Yamashita, Kiyoshi Watanabe
  • 3,5-di-Tert-butylstyrene derivatives, salts thereof, and pharmaceutical compositions containing the same as an active ingredient
    Patent number: 4431656
    Abstract: Novel compounds, 3,5-di-tert-butylstyrene derivatives and their salts, are disclosed, which derivatives are represented by the general formula: ##STR1## wherein R.sup.1 stands for an acyloxy group represented by R.sup.3 COO (R.sup.3 is a hydrogen atom or an alkyl group with C.sub.1 -C.sub.6), an alkoxyl group of R.sub.4 O (R.sup.4 is an alkyl group with C.sub.1 -C.sub.4), a hydroxyl group, or a hydrogen atom; R.sup.2 stands for ##STR2## (R.sup.5 is a hydrogen atom or an alkyl group with C.sub.1 -C.sub.3 and X.sup.1 is CH.sub.2 or an oxygen atom), ##STR3## (R.sup.5 and X.sup.1 are each the same as defined above), or ##STR4## (X.sup.2 is an oxygen or sulfur atom).
    Type: Grant
    Filed: January 5, 1982
    Date of Patent: February 14, 1984
    Assignee: Kanegafuchi Chemical Industry Company Limited
    Inventors: Ikuo Katsumi, Hideo Kondo, Katsuji Yamashita, Takayoshi Hidaka, Kazunori Hosoe, Yutaka Ariki, Toshiaki Yamashita, Kiyoshi Watanabe