Abstract: A display system includes a display provided in a vehicle to display a video captured by a camera provided in the vehicle to capture a scene around the vehicle, and a controller that switches, when it is predicted that a passenger of the vehicle will leave the vehicle, a mode of the display system from a first mode to a second mode. In the first mode, the controller clips a first video in a first area from a video frame captured by the camera and outputs the first video to the display. In the second mode, the controller clips a second video in a second area from the video frame captured by the camera and outputs the second video to the display. The second area is different from the first area.

Abstract: A video acquisition unit acquires a video from an imaging unit provided in a vehicle to capture a scene around the vehicle. A display unit is provided in the vehicle to display the video captured by the imaging unit. A control unit switches, when it is predicted that a passenger of the vehicle will leave the vehicle, a mode of the display system to a mode in which visibility for the passenger is improved.

Abstract: An aqueous microcapsule dispersion liquid containing a component (A) and a component (B): component (A): microcapsules having a shell including an inorganic material as a constitutional component, and a core including one or more of an organic compound, inside the shell, and component (B): one or more selected from the group consisting of a neutral amino acid (B1), a polyhydroxyamine (B2), and a quaternary ammonium hydroxide (B3).

Abstract: The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: wherein R represents a hydrogen atom or a protective group for carboxylic acid and X2 represents a halogen atom; the method including the steps of reacting a Grignard reagent with a halogeno penam compound represented by General Formula (1) below: wherein R and X2 are the same as above, and X1 represents a halogen atom; reacting the generated compound with an amine compound; and further reacting the generated compound with acetaldehyde.

Abstract: A process for preparing 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) and an alkali metal salt thereof, said acid and said salt being improved in the content of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (2) or an alkali metal salt thereof, the process being characterized in that an aqueous solution of an alkali metal salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) is treated with a high porous polymer and/or active carbon as added thereto.

Abstract: A 3-alkenylcephem compound of the formula (1) wherein R1 is benzyl or phenoxymethyl, R2, R3 and R4 are alike or different and are each a hydrogen atom, C1-10 alkyl, C4-8 cycloalkyl or aryl C1-3 alkyl substituted or unsubstituted with C1-4 alkyl, R2 and R3, when taken together, form a group —(CH2)lXm(CH2)n— substituted or unsubstituted with C1-4 alkyl at an optional position, X is an oxygen atom or group —N(R5)—, l is 0 to 3, m is 0 or 1, n is an integer of 2 to 4, R5 is a hydrogen atom or C1-4 alkyl.

Abstract: The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: wherein R represents a hydrogen atom or a protective group for carboxylic acid and X2 represents a halogen atom; the method including the steps of reacting a Grignard reagent with a halogeno penam compound represented by General Formula (1) below: wherein R and X2 are the same as above, and X1 represents a halogen atom; reacting the generated compound with an amine compound; and further reacting the generated compound with acetaldehyde.

Abstract: The present invention provides 2?-chloromethyl-2?-methylpenam-3?-carboxylic acid benzhydryl ester (CMPB) crystals of excellent stability, and a process for producing the CMPB crystals comprising the steps of (A) concentrating a solution containing CMPB; (b) subjecting the thus-obtained concentrate to column chromatography; (C) concentrating a CMPB-containing fraction; and (D) dissolving the thus-obtained CMPB-containing concentrate in an ether solvent and adding a hydrocarbon solvent to the resulting solution to precipitate CMPB crystals.

Abstract: A 3-alkenylcephem compound of the formula (1) wherein R1 is benzyl or phenoxymethyl, R2, R3 and R4 are alike or different and are each a hydrogen atom, C1-10 alkyl, C4-8 cycloalkyl or aryl C1-3 alkyl substituted or unsubstituted with C1-4 alkyl, R2 and R3, when taken together, form a group —(CH2)lXm(CH2)n— substituted or unsubstituted with C1-4 alkyl at an optional position, X is an oxygen atom or group —N(R5)—, l is 0 to 3, m is 0 or 1, n is an integer of 2 to 4, R5 is a hydrogen atom or C1-4 alkyl.

Abstract: A process for preparing 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) and an alkali metal salt thereof, said acid and said salt being improved in the content of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (2) or an alkali metal salt thereof, the process being characterized in that an aqueous solution of an alkali metal salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) is treated with a high porous polymer and/or active carbon as added thereto.

Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.

Abstract: The present invention provides 2?-chloromethyl-2?-methylpenam-3?-carboxylic acid benzhydryl ester (CMPB) crystals of excellent stability, and a process for producing the CMPB crystals comprising the steps of (A) concentrating a solution containing CMPB; (b) subjecting the thus-obtained concentrate to column chromatography; (C) concentrating a CMPB-containing fraction; and (D) dissolving the thus-obtained CMPB-containing concentrate in an ether solvent and adding a hydrocarbon solvent to the resulting solution to precipitate CMPB crystals.

Abstract: A 3-cephem derivative crystal which is a clathrate compound comprising p-methoxybenzyl ester of 7-phenylacetamide-3-formyl-3-cephem-4-carboxylic acid and dimethylformamide and a process for preparing the 3-cephem derivative crystal.

Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.

Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.

Abstract: A 3-cephem derivative crystal which is a clathrate compound comprising p-methoxybenzyl ester of 7-phenylacetamide-3-formyl-3-cephem-4-carboxylic acid and dimethylformamide and a process for preparing the 3-cephem derivative crystal.

Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.

Abstract: 1. A process for preparing a 3-alkenylcephem compound or 3-norcephem compound of the formula (3) characterized in that an alkenyl halide of the formula (2), a nickel catalyst, a metal up to −0.3 (V/SCE) in standard oxidation reduction potential and a compound of a metal having a higher standard oxidation reduction potential than the metal are caused to act on a 3-cephem compound of the formula (1) in a solvent wherein R1 is a hydrogen atom or the like, R2 is a hydrogen atom or the like, R3 is a hydrogen atom or carboxylic acid protective group, and X is a halogen atom or the like, R4—Y  (2) wherein R4 is 1-alkenyl having or not having a substituent, and Y is a halogen atom wherein R1, R2 and R3 are as defined above, and R5 is a hydrogen atom or 1-alkenyl having or not having a substituent.

Abstract: 3-Halogenomethylcephem compound of the formula (2) or its salt is obatined by deprotecting with phenol derivative a carboxylic acid protecting group at the 4-position of 7-amino-3-halogenomethylcephem compound of the formula (1) or its salt Further 3-thiomethylcephem compound of the formula (4) or its salt is prepared by reacting 3-halogenomethylcephem compound of the formula (2) or its salt with thiol compound or its salt of the formula (3) wherein X1, R1, R2 and M are as defined in the specification.

Abstract: The object of the invention is to provide cephalosporin crystals which are highly stable for a long period under economical storage conditions. The cephalosporin crystals of the invention are obtainable by crystallizing an oily cephalosporin in a solvent containing an alcohol.