Patents by Inventor Yutaka Kameyama
Yutaka Kameyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240325261Abstract: An aqueous microcapsule dispersion liquid containing a component (A) and a component (B): component (A): microcapsules having a shell including an inorganic material as a constitutional component, and a core including one or more of an organic compound, inside the shell, and component (B): one or more selected from the group consisting of a neutral amino acid (B1), a polyhydroxyamine (B2), and a quaternary ammonium hydroxide (B3).Type: ApplicationFiled: June 29, 2022Publication date: October 3, 2024Applicant: KAO CORPORATIONInventors: Yoshito KOGA, Keita FUKUZUMI, Yutaka KAMEYAMA, Hironori KONO
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Patent number: 8293893Abstract: The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: wherein R represents a hydrogen atom or a protective group for carboxylic acid and X2 represents a halogen atom; the method including the steps of reacting a Grignard reagent with a halogeno penam compound represented by General Formula (1) below: wherein R and X2 are the same as above, and X1 represents a halogen atom; reacting the generated compound with an amine compound; and further reacting the generated compound with acetaldehyde.Type: GrantFiled: March 6, 2008Date of Patent: October 23, 2012Assignee: Otsuka Chemical Co., Ltd.Inventors: Hideo Tanaka, Manabu Kuroboshi, Syoichi Tateyama, Takae Yamada, Yutaka Kameyama
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Patent number: 7893254Abstract: A process for preparing 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) and an alkali metal salt thereof, said acid and said salt being improved in the content of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (2) or an alkali metal salt thereof, the process being characterized in that an aqueous solution of an alkali metal salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) is treated with a high porous polymer and/or active carbon as added thereto.Type: GrantFiled: June 3, 2005Date of Patent: February 22, 2011Assignees: Otsuka Chemical Co., Ltd., Meiji Seika Kaisha Ltd.Inventors: Yoichi Nishioka, Masahiro Ito, Yutaka Kameyama
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Patent number: 7759483Abstract: A 3-alkenylcephem compound of the formula (1) wherein R1 is benzyl or phenoxymethyl, R2, R3 and R4 are alike or different and are each a hydrogen atom, C1-10 alkyl, C4-8 cycloalkyl or aryl C1-3 alkyl substituted or unsubstituted with C1-4 alkyl, R2 and R3, when taken together, form a group —(CH2)lXm(CH2)n— substituted or unsubstituted with C1-4 alkyl at an optional position, X is an oxygen atom or group —N(R5)—, l is 0 to 3, m is 0 or 1, n is an integer of 2 to 4, R5 is a hydrogen atom or C1-4 alkyl.Type: GrantFiled: June 2, 2005Date of Patent: July 20, 2010Assignee: Otsuka Chemical Co., Ltd.Inventors: Yoichi Nishioka, Koichi Sorajo, Yutaka Kameyama
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Publication number: 20100113769Abstract: The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: wherein R represents a hydrogen atom or a protective group for carboxylic acid and X2 represents a halogen atom; the method including the steps of reacting a Grignard reagent with a halogeno penam compound represented by General Formula (1) below: wherein R and X2 are the same as above, and X1 represents a halogen atom; reacting the generated compound with an amine compound; and further reacting the generated compound with acetaldehyde.Type: ApplicationFiled: March 6, 2008Publication date: May 6, 2010Applicant: OTSUKA CHEMICAL CO., LTD.Inventors: Hideo Tanaka, Manabu Kuroboshi, Syoichi Tateyama, Takae Yamada, Yutaka Kameyama
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Patent number: 7692003Abstract: The present invention provides 2?-chloromethyl-2?-methylpenam-3?-carboxylic acid benzhydryl ester (CMPB) crystals of excellent stability, and a process for producing the CMPB crystals comprising the steps of (A) concentrating a solution containing CMPB; (b) subjecting the thus-obtained concentrate to column chromatography; (C) concentrating a CMPB-containing fraction; and (D) dissolving the thus-obtained CMPB-containing concentrate in an ether solvent and adding a hydrocarbon solvent to the resulting solution to precipitate CMPB crystals.Type: GrantFiled: October 8, 2004Date of Patent: April 6, 2010Assignees: Otsuka Chemical Co., Ltd., Taiho Pharmaceutical Co., Ltd.Inventors: Isao Wada, Yutaka Kameyama
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Publication number: 20080064869Abstract: A 3-alkenylcephem compound of the formula (1) wherein R1 is benzyl or phenoxymethyl, R2, R3 and R4 are alike or different and are each a hydrogen atom, C1-10 alkyl, C4-8 cycloalkyl or aryl C1-3 alkyl substituted or unsubstituted with C1-4 alkyl, R2 and R3, when taken together, form a group —(CH2)lXm(CH2)n— substituted or unsubstituted with C1-4 alkyl at an optional position, X is an oxygen atom or group —N(R5)—, l is 0 to 3, m is 0 or 1, n is an integer of 2 to 4, R5 is a hydrogen atom or C1-4 alkyl.Type: ApplicationFiled: June 2, 2005Publication date: March 13, 2008Inventors: Yoichi Nishioka, Koichi Sorajo, Yutaka Kameyama
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Publication number: 20080033166Abstract: A process for preparing 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) and an alkali metal salt thereof, said acid and said salt being improved in the content of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (2) or an alkali metal salt thereof, the process being characterized in that an aqueous solution of an alkali metal salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) is treated with a high porous polymer and/or active carbon as added thereto.Type: ApplicationFiled: June 3, 2005Publication date: February 7, 2008Inventors: Yoichi Nishioka, Msahiro Ito, Yutaka Kameyama
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Patent number: 7183421Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.Type: GrantFiled: August 11, 2004Date of Patent: February 27, 2007Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Hideo Tanaka, Yutaka Kameyama
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Publication number: 20060293516Abstract: The present invention provides 2?-chloromethyl-2?-methylpenam-3?-carboxylic acid benzhydryl ester (CMPB) crystals of excellent stability, and a process for producing the CMPB crystals comprising the steps of (A) concentrating a solution containing CMPB; (b) subjecting the thus-obtained concentrate to column chromatography; (C) concentrating a CMPB-containing fraction; and (D) dissolving the thus-obtained CMPB-containing concentrate in an ether solvent and adding a hydrocarbon solvent to the resulting solution to precipitate CMPB crystals.Type: ApplicationFiled: October 8, 2004Publication date: December 28, 2006Inventors: Isao Wada, Yutaka Kameyama
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Patent number: 6887992Abstract: A 3-cephem derivative crystal which is a clathrate compound comprising p-methoxybenzyl ester of 7-phenylacetamide-3-formyl-3-cephem-4-carboxylic acid and dimethylformamide and a process for preparing the 3-cephem derivative crystal.Type: GrantFiled: October 7, 2003Date of Patent: May 3, 2005Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Takashi Moriyoshi, Yasuhiro Uosaki, Yutaka Kameyama, Daisuke Suzuki, Yoshiko Seo
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Publication number: 20050014957Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.Type: ApplicationFiled: August 11, 2004Publication date: January 20, 2005Inventors: Hideo Tanaka, Yutaka Kameyama
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Patent number: 6797830Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.Type: GrantFiled: November 28, 2001Date of Patent: September 28, 2004Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Hideo Tanaka, Yutaka Kameyama
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Publication number: 20040073023Abstract: A 3-cephem derivative crystal which is a clathrate compound comprising p-methoxybenzyl ester of 7-phenylacetamide-3-formyl-3-cephem-4-carboxylic acid and dimethylformamide and a process for preparing the 3-cephem derivative crystal.Type: ApplicationFiled: October 7, 2003Publication date: April 15, 2004Inventors: Takashi Moriyoshi, Yasuhiro Uosaki, Yutaka Kameyama, Daisuke Suzuki, Yoshiko Seo
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Publication number: 20030114712Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.Type: ApplicationFiled: November 28, 2001Publication date: June 19, 2003Inventors: Hideo Tanaka, Yutaka Kameyama
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Patent number: 6576761Abstract: 1. A process for preparing a 3-alkenylcephem compound or 3-norcephem compound of the formula (3) characterized in that an alkenyl halide of the formula (2), a nickel catalyst, a metal up to −0.3 (V/SCE) in standard oxidation reduction potential and a compound of a metal having a higher standard oxidation reduction potential than the metal are caused to act on a 3-cephem compound of the formula (1) in a solvent wherein R1 is a hydrogen atom or the like, R2 is a hydrogen atom or the like, R3 is a hydrogen atom or carboxylic acid protective group, and X is a halogen atom or the like, R4—Y (2) wherein R4 is 1-alkenyl having or not having a substituent, and Y is a halogen atom wherein R1, R2 and R3 are as defined above, and R5 is a hydrogen atom or 1-alkenyl having or not having a substituent.Type: GrantFiled: February 7, 2002Date of Patent: June 10, 2003Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Hideo Tanaka, Yutaka Kameyama
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Patent number: 6448393Abstract: 3-Halogenomethylcephem compound of the formula (2) or its salt is obatined by deprotecting with phenol derivative a carboxylic acid protecting group at the 4-position of 7-amino-3-halogenomethylcephem compound of the formula (1) or its salt Further 3-thiomethylcephem compound of the formula (4) or its salt is prepared by reacting 3-halogenomethylcephem compound of the formula (2) or its salt with thiol compound or its salt of the formula (3) wherein X1, R1, R2 and M are as defined in the specification.Type: GrantFiled: April 14, 2000Date of Patent: September 10, 2002Assignee: Otsuka Kagaku Kabushiki KaishaInventor: Yutaka Kameyama
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Publication number: 20020099206Abstract: The object of the invention is to provide cephalosporin crystals which are highly stable for a long period under economical storage conditions. The cephalosporin crystals of the invention are obtainable by crystallizing an oily cephalosporin in a solvent containing an alcohol.Type: ApplicationFiled: January 9, 2002Publication date: July 25, 2002Inventors: Yutaka Kameyama, Takashi Shiroi
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Patent number: 6420554Abstract: A process for preparing a 3-cephem compound represented by the formula (3), the process comprising the steps of reacting a &bgr;-lactam compound represented by the formula (1) with a phosphorus halide compound in the presence of an organic base to give an imino-&bgr;-lactam compound represented by the formula (2), adding a phenol to the same reaction system to cause decomposition due to reaction with an alcohol and simultaneously to remove the protection of carboxylic acid ester, giving a 3-cephem compound represented by the formula (3) or a salt thereof where R1, R2, R3 and X are as defined above.Type: GrantFiled: February 29, 2000Date of Patent: July 16, 2002Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Yutaka Kameyama, Takae Yamada, Dal Soo Suh
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Patent number: 6417351Abstract: A process for preparing 3-alkenylcephem compounds characterized in that 3-alkenylcephem compound of the formula (3) is prepared in a single step by simultaneously conducting reactions of a 3-chloromethylcephem compound of the formula (1) with iodization reagent, alkali metal hydroxide or carbonate, arylphosphine and an aldehyde of the formula (2) R4—CHO (2) wherein R1, R2, R3 and R4 are as defined in the specification.Type: GrantFiled: December 1, 1999Date of Patent: July 9, 2002Assignee: Otsuka Kagaku Kabushiki KaishaInventor: Yutaka Kameyama