Abstract: Crystals of the compound represented by formula (1), a method for the production thereof, and a method for producing an antibody-drug conjugate using the crystals.

Abstract: Crystals of the compound represented by formula (1), a method for the production thereof, and a method for producing an antibody-drug conjugate using the crystals.

Abstract: An object of the present invention is to provide an optically active bicyclic ?-amino acid derivative in a high purity.

Abstract: An object of the present invention is to provide an optically active bicyclic ?-amino acid derivative in a high purity.

Abstract: Provided is a production method for a cis-QMF, which has a low environmental burden and is industrially advantageous. Specifically provided is a production method for a cis-type 2-alkylspiro(1,3-oxathiolane-5,3?)quinuclidine hydrochloride, including: reacting a cis-trans isomer mixture of 2-alkylspiro(1,3-oxathiolane-5,3?)quinuclidine with p-nitrobenzoic acid; resolving the resultant product to produce a cis-type 2-alkylspiro(1,3-oxathiolane-5,3?)quinuclidine p-nitrobenzoate; and converting the p-nitrobenzoate into a hydrochloride.

Abstract: It is desired to reduce the danger of leakage of data stored in a logical storage device. A storage system has a detection unit and a security processing unit. The detection unit detects a system change, during which it is not possible to perform I/O for a first logical storage device, among a plurality of logical storage devices in the storage system. And the security processing unit takes this type of system change as the opportunity for performing security processing, i.e. formatting or shredding, upon the first logical storage device.

Abstract: Provided is a production method for a cis-QMF, which has a low environmental burden and is industrially advantageous. Specifically provided is a production method for a cis-type 2-alkylspiro(1,3-oxathiolane-5,3?)quinuclidine hydrochloride, including: reacting a cis-trans isomer mixture of 2-alkylspiro(1,3-oxathiolane-5,3?)quinuclidine with p-nitrobenzoic acid; resolving the resultant product to produce a cis-type 2-alkylspiro(1,3-oxathiolane-5,3?)quinuclidine p-nitrobenzoate; and converting the p-nitrobenzoate into a hydrochloride.

Abstract: The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent.

Abstract: An apparatus for storing a device for a railway vehicle, comprises a storage case having an opening at a front side, a tray accommodated into the storage case, the tray being movable forward and backward with the device mounted thereon, a lever disposed at an upper side of the tray to extend along a forward and backward direction, the lever being vertically pivotable around a pivot forward relative to a center of the tray in the forward and backward direction, an operation member coupled to a front end portion of the lever and disposed at a front side of the tray, an engagement portion provided at a rear end portion of the lever and protruding downward outside the tray, and a recess provided in the storage case, the engagement portion being fitted into the recess from above.

Abstract: A waterproof cable guide device for a railway vehicle comprises an elastic member having a plurality of through-holes penetrating in a forward and backward direction and screw insertion holes penetrating in the forward and backward direction, the plurality of electric cables being inserted into the plurality of holes, respectively, the elastic member being divided in positions of the through-holes or having slits extending from an outer peripheral surface of the elastic member to the through-holes, respectively; a press casing surrounding a front surface and an outer peripheral surface of the elastic member so as not to cover the through-holes and provided with screw insertion holes communicating with the screw insertion holes of the elastic member; and screws inserted into the screw insertion holes, in a direction from forward, and tightened with respect to the cable guide; the screws being inserted into the screw insertion holes in the direction from forward and tightened with respect to the cable guide in

Abstract: Methods for producing compounds having activity as an ?2? ligand are provided.

Abstract: A waterproof cable guide device for a railway vehicle, comprises an elastic member of a substantially rectangular prism shape, which has a plurality of through-holes into which the plurality of electric cables are inserted, respectively, the plurality of through-holes penetrating the elastic member in a forward and backward direction, the elastic member being divided in positions of the through-holes or having slits extending from an outer peripheral surface of the elastic member to the through-holes, respectively; a plurality of divided press casings into which a casing is divided in a vertical direction and in a lateral direction, the plurality of divided press casings surrounding a front surface, right and left side surfaces and upper and lower surfaces of the elastic member so as not to cover the through-holes; a first fastener member which tightens the plurality of divided press casings toward the cable guide; a second fastener member which tightens the plurality of divided press casings closer to each o

Abstract: The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent.

Abstract: Methods for producing compounds having activity as an ?2? ligand are provided.

Abstract: The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent. Specifically, the invention provides a method for producing a compound of formula (2): wherein n is an integer of 2 to 5; R1 is a (substituted) alkyl group or a (substituted) aryl group; and R2 represents a (substituted) alkoxycarbonyl group, a (substituted) aralkyloxycarbonyl group, a (substituted) aliphatic acyl group, or a (substituted) aromatic acyl group).

Abstract: In a storage apparatus comprising a communication interface that receives an I/O request sent from a host apparatus, a storage device controller that performs writing and reading of data with respect to a storage device, and a cache memory that stores data to be written in the storage device or data read from the storage device, a journal volume operated as a volume for which update writing is prohibited and write once is permitted is provided, on the basis of a storage area provided by the storage device, and a virtual volume is provided as a volume accessible from the host apparatus, the journal volume being the entity of the virtual volume, the virtual volume being a volume for which an attribute (Read/Add) that permits only reading and write once is settable.

Abstract: A waterproof cable guide device for a railway vehicle, comprises an elastic member of a substantially rectangular prism shape, which has a plurality of through-holes into which the plurality of electric cables are inserted, respectively, the plurality of through-holes penetrating the elastic member in a forward and backward direction, the elastic member being divided in positions of the through-holes or having slits extending from an outer peripheral surface of the elastic member to the through-holes, respectively; a plurality of divided press casings into which a casing is divided in a vertical direction and in a lateral direction, the plurality of divided press casings surrounding a front surface, right and left side surfaces and upper and lower surfaces of the elastic member so as not to cover the through-holes; a first fastener member which tightens the plurality of divided press casings toward the cable guide; a second fastener member which tightens the plurality of divided press casings closer to each o

Abstract: A waterproof cable guide device for a railway vehicle comprises an elastic member having a plurality of through-holes penetrating in a forward and backward direction and screw insertion holes penetrating in the forward and backward direction, the plurality of electric cables being inserted into the plurality of holes, respectively, the elastic member being divided in positions of the through-holes or having slits extending from an outer peripheral surface of the elastic member to the through-holes, respectively; a press casing surrounding a front surface and an outer peripheral surface of the elastic member so as not to cover the through-holes and provided with screw insertion holes communicating with the screw insertion holes of the elastic member; and screws inserted into the screw insertion holes, in a direction from forward, and tightened with respect to the cable guide; the screws being inserted into the screw insertion holes in the direction from forward and tightened with respect to the cable guide in

Abstract: An apparatus for storing a device for a railway vehicle, comprises a storage case having an opening at a front side, a tray accommodated into the storage case, the tray being movable forward and backward with the device mounted thereon, a lever disposed at an upper side of the tray to extend along a forward and backward direction, the lever being vertically pivotable around a pivot forward relative to a center of the tray in the forward and backward direction, an operation member coupled to a front end portion of the lever and disposed at a front side of the tray, an engagement portion provided at a rear end portion of the lever and protruding downward outside the tray, and a recess provided in the storage case, the engagement portion being fitted into the recess from above.

Abstract: A process for producing an optically active compound represented by formula (4) or a salt thereof: the process including reacting a cyclization reagent with an optically active compound represented by formula (3) or its salt: optionally in the presence of a Lewis acid, to form the compound of formula (4) or its salt, wherein, in the compounds of formula (3) and formula (4) and their salts, R1 is a protecting group, and wherein the cyclization reagent is prepared from a titanium (IV) reagent and an alkylmetal compound.