Abstract: There has been developed a safety valve installed on a small-sized cell vessel which remains hermetically sealed during the normal operation but which instantly releases the pressure in the inside of the vessel if, due to abnormalities, such as overcharging, the pressure is increased and reaches a prescribed value to prevent explosion or deformation of the cell vessel to evade the risk to the human being or destruction of the equipment. The metal foil type safety valve by the cold pressure welding of the present invention cold-pressure-welds the metal foil for sealing the air vent hole in the metal vessel. If the internal pressure in the vessel reaches the prescribed value, the metal foil is cleft to form an opening in the vessel to release the internal pressure.

Abstract: The present invention is concerned with a cleavage type safety valve installed on a metal vessel for affording the explosion-proof function. The safety valve is installed on a small-sized cell vessel which remains hermetically sealed during the normal operation but instantly releases the pressure in the inside of the vessel if, due to abnormalities, such as overcharging, the pressure is increased and reaches a prescribed value to prevent explosion or deformation of the cell vessel. The metal foil type safety valve by the cold pressure welding of the present invention cold welds the metal foil for sealing the air vent hole in the metal vessel. If the internal pressure in the vessel reaches the prescribed value, the metal foil is cleft to form an opening in the vessel to release the internal pressure.

Abstract: A patch having good transdermal property which utilizes a suppository base e.g. triglyceride of a vegetable saturated fatty acid having 12 to 18 carbon atoms together with a penetration enhancer.

Abstract: A novel plaster structural assembly is provided for iontophoresis wherein th e assembly is comprised of an electrode layer and a medicament-containing layer in which a water supplying layer is disposed between the electrode layer and the medicament-containing layer with a sealing cover disposed on the outside of the electrode layer. A method for using the structural assembly for iontophoresis is also provided.

Abstract: A patch having good transdermal property which utilizes a suppository base e.g. triglyceride of a vegetable saturated fatty acid having 12 to 18 carbon atoms together with a penetration enhancer.

Abstract: A formulation is provided for the transdermal administration of nicardipine hydrochloride. The formulation is comprised of nicardipine hydrochloride dissolved or suspended in a mixed liquid composed of an urea and at least one compound selected from the group consisting of propylene glycol, a monohydric alcohol having 2 to 4 carbon atoms, lactic acid, thioglycol, a middle chain fatty acid glyceride and a sorbitan middle chain fatty acid ester compounded with a transdermal formulation base.

Abstract: An oily composition of an antitumor drug comprising at least one sparingly oil soluble or water-soluble antitumor drug, at least one fat or oil, and at least one solubilizing adjuvant in an oily vehicle selected from the group consisting of crown ether, lecithin, polyethylene glycol, propylene glycol, vitamin E, polyoxyethylene alkylether, and sucrose esters of fatty acids.

Abstract: A solid microdose drug preparation containing a microdose drug such as formoterol fumarate or .beta.-methyldigoxin coated with wax.In the drug preparation, the stability and the content uniformity of the microdose drug have been improved.

Abstract: A stable suppository useful as an antiasthmatic agent containing 3-formylamino-4-hydroxy-.alpha.-[N-(1-methyl-2-p-methoxyphenylethyl)aminom ethyl]benzyl alcohol.1/2fumarate monohydrate, polyvinyl pyrrolidone, and at least one of cyclodextrin, dextran and magnesium metasilicate aluminate together with a suppository base.