Patents by Inventor Yutaka Kono
Yutaka Kono has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10024789Abstract: A differential refractometer including a measurement section for measuring the diffractive index difference between a sample cell and a reference cell by radiating light on a measurement cell and detecting light which has sequentially passed through the sample cell and the reference cell includes a mobile phase supply section for delivering a mobile phase in a sample introduction channel that is connected to the sample cell. The mobile phase supply section includes a mobile phase container for containing the mobile phase. The inside of the mobile phase container is continuously stirred by a stirring mechanism, and the composition of the mobile phase inside the mobile phase container is made uniform.Type: GrantFiled: February 7, 2014Date of Patent: July 17, 2018Assignee: SHIMADZU CORPORATIONInventors: Kumiko Jingu, Masanori Fujiwara, Masami Tomita, Yutaka Kono
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Publication number: 20170010213Abstract: A differential refractometer including a measurement section for measuring the diffractive index difference between a sample cell and a reference cell by radiating light on a measurement cell and detecting light which has sequentially passed through the sample cell and the reference cell includes a mobile phase supply section for delivering a mobile phase in a sample introduction channel that is connected to the sample cell. The mobile phase supply section includes a mobile phase container for containing the mobile phase. The inside of the mobile phase container is continuously stirred by a stirring mechanism, and the composition of the mobile phase inside the mobile phase container is made uniform.Type: ApplicationFiled: February 7, 2014Publication date: January 12, 2017Applicant: SHIMADZU CORPORATIONInventors: Kumiko Jingu, Masanori Fujiwara, Masami Tomita, Yutaka Kono
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Patent number: 9259669Abstract: Collection containers (17) are heated by head conduction from a container rack (18) with a heater (19) as the heat source. When an eluting solvent is supplied into a trap column (7) by a pump (5), an eluate containing a target compound exiting from the column (7) flows through a preparative separation passage (13) and drips from a solution nozzle (13a), and this solution is separated into fine droplets by a gas stream blowing from a gas ejection nozzle (15a). When a droplet touches an inner wall of the container (17), the volatile solvent immediately vaporizes, leaving the target compound precipitated in solid forms on the inner wall. Thus, the process of vaporizing and drying the eluate to collect the target compound is completed within a short period of time. This process can be performed online and hence is suitable for laborsaving.Type: GrantFiled: October 2, 2007Date of Patent: February 16, 2016Assignee: SHIMADZU CORPORATIONInventors: Yutaka Kono, Masayuki Nishimura, Bob Boughtflower, Przemyslaw Stasica
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Patent number: 8974666Abstract: A solution containing a target compound is passed through a trap column (14) to capture the target compound in the column (14). Thereafter, wash water is introduced in the trap column (14). Then, the setting of a six-port valve (7) is changed and an on/off valve (6) is opened to introduce nitrogen gas through a supply-side passage (8) in the trap column (14). In this stage, the nitrogen gas is warmed by means of a heat-exchange block (10), and the trap column (14) is warmed via a column rack (15). Any water remaining in the trap column (14) is initially thrust upwards by the nitrogen gas, to be extruded from an exit edge (14b) and discharged through a discharge-side passage (20). Furthermore, any water adhering to adsorbent or the inner wall surface of the trap column (14) is quickly vaporized and carried away by the nitrogen gas.Type: GrantFiled: October 2, 2007Date of Patent: March 10, 2015Assignee: Shimadzu CorporationInventors: Yutaka Kono, Masayuki Nishimura, Bob Boughtflower, Przemyslaw Stasica
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Patent number: 8968561Abstract: A mixed liquid passage (31) is connected to a trapping passage (22) at a point upstream of a trap column (23). A mixture of a diluting liquid and an additive agent, which are respectively drawn and sent by pumps (35) and (36), is supplied into the mixed liquid passage (31). When an eluate containing a target compound is passed through the trap column (23), the eluate is diluted with the diluting liquid and hence its elution capability decreases, so that the target compound can be easily captured in the trap column (23). Meanwhile, the solubility of the mobile phase in the eluate decreases, causing not only the target component but also foreign compounds to more easily precipitate. However, their precipitation is prevented by the effect of the additive agent. Thus, clogging of the trap column (23) or pipes is prevented.Type: GrantFiled: October 2, 2007Date of Patent: March 3, 2015Assignee: Shimadzu CorporationInventors: Yutaka Kono, Masayuki Nishimura, Bob Boughtflower, Przemyslaw Stasica
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Patent number: 8607620Abstract: After a target compound is captured by an adsorbent within a trap column (7) held by a column rack (8) in a substantially vertical position and the column is filled with water to wash its inside, dichloromethane is slowly introduced from an inlet end (7a) on the lower side by a pump (5). The water within the trap column (7) is pushed upward by dichloromethane and exits from an outlet end (7b), to be disposed of via a two-way selector valve (12) and a disposal passage (14). Dichloromethane elutes the captured target compound. Therefore, when the eluate, which initially consists of water, changes via an emulsion to dichloromethane, the eluate contains an adequately high concentration of target compound. At this point, the two-way valve (12) is switched to a preparative separation passage (13). As a result, a solution that is adequately free from water and yet contains the target compound can be collected into a collection container (17), and the target compound in solid forms can be quickly obtained.Type: GrantFiled: October 2, 2007Date of Patent: December 17, 2013Assignee: Shimadzu CorporationInventors: Yutaka Kono, Masayuki Nishimura, Bob Boughtflower, Przemyslaw Stasica
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Publication number: 20100300627Abstract: Collection containers (17) are heated by head conduction from a container rack (18) with a heater (19) as the heat source. When an eluting solvent is supplied into a trap column (7) by a pump (5), an eluate containing a target compound exiting from the column (7) flows through a preparative separation passage (13) and drips from a solution nozzle (13a), and this solution is separated into fine droplets by a gas stream blowing from a gas ejection nozzle (15a). When a droplet touches an inner wall of the container (17), the volatile solvent immediately vaporizes, leaving the target compound precipitated in solid forms on the inner wall. Thus, the process of vaporizing and drying the eluate to collect the target compound is completed within a short period of time. This process can be performed online and hence is suitable for laborsaving.Type: ApplicationFiled: October 2, 2007Publication date: December 2, 2010Applicant: Shimadzu CorporationInventors: Yutaka Kono, Masayuki Nishimura, Bob Boughtflower, Przemyslaw Stasica
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Publication number: 20100281958Abstract: After a target compound is captured by an adsorbent within a trap column (7) held by a column rack (8) in a substantially vertical position and the column is filled with water to wash its inside, dichloromethane is slowly introduced from an inlet end (7a) on the lower side by a pump (5). The water within the trap column (7) is pushed upward by dichloromethane and exits from an outlet end (7b), to be disposed of via a two-way selector valve (12) and a disposal passage (14). Dichloromethane elutes the captured target compound. Therefore, when the eluate, which initially consists of water, changes via an emulsion to dichloromethane, the eluate contains an adequately high concentration of target compound. At this point, the two-way valve (12) is switched to a preparative separation passage (13). As a result, a solution that is adequately free from water and yet contains the target compound can be collected into a collection container (17), and the target compound in solid forms can be quickly obtained.Type: ApplicationFiled: October 2, 2007Publication date: November 11, 2010Applicant: Shimadzu CorporationInventors: Yutaka Kono, Masayuki Nishimura, Bob Boughtflower, Przemyslaw Stasica
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Publication number: 20100276350Abstract: A mixed liquid passage (31) is connected to a trapping passage (22) at a point upstream of a trap column (23). A mixture of a diluting liquid and an additive agent, which are respectively drawn and sent by pumps (35) and (36), is supplied into the mixed liquid passage (31). When an eluate containing a target compound is passed through the trap column (23), the eluate is diluted with the diluting liquid and hence its elution capability decreases, so that the target compound can be easily captured in the trap column (23). Meanwhile, the solubility of the mobile phase in the eluate decreases, causing not only the target component but also foreign compounds to more easily precipitate. However, their precipitation is prevented by the effect of the additive agent. Thus, clogging of the trap column (23) or pipes is prevented.Type: ApplicationFiled: October 2, 2007Publication date: November 4, 2010Applicant: SHIMADZU CORPORATIONInventors: Yutaka Kono, Masayuki Nishimura, Bob Boughtflower, Przemyslaw Stasica
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Publication number: 20100258485Abstract: A solution containing a target compound is passed through a trap column (14) to capture the target compound in the column (14). Thereafter, wash water is introduced in the trap column (14). Then, the setting of a six-port valve (7) is changed and an on/off valve (6) is opened to introduce nitrogen gas through a supply-side passage (8) in the trap column (14). In this stage, the nitrogen gas is warmed by means of a heat-exchange block (10), and the trap column (14) is warmed via a column rack (15). Any water remaining in the trap column (14) is initially thrust upwards by the nitrogen gas, to be extruded from an exit edge (14b) and discharged through a discharge-side passage (20). Furthermore, any water adhering to adsorbent or the inner wall surface of the trap column (14) is quickly vaporized and carried away by the nitrogen gas.Type: ApplicationFiled: October 2, 2007Publication date: October 14, 2010Applicant: SHIMADZU CORPORATIONInventors: Yutaka Kono, Masayuki Nishimura, Bob Boughtflower, Przemyslaw Stasica
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Publication number: 20030032834Abstract: A compound of the formula [Ig]; wherein R1 is hydrogen or an amino protective group, R2 is hydrogen or hydroxy, and R3 and R4 are independently N-methyl-methoxycarbonylamino, N-ethyl-methoxycarbonylamino, N-propyl-methoxycarbonylamino or 3-ethylureid, or R3 and R4 are both methoxycarbonylamino substituted at a meta position of the benzene rings, or a salt thereof, and (2S)-1-phenoxy-3-[3,3-bis[4-methoxycarbonylamino)-phenyl]propylamino]-2-propanol sulfate (2:1) and some crystal forms thereof as &bgr;3adrenergic receptor agonists.Type: ApplicationFiled: August 19, 2002Publication date: February 13, 2003Inventors: Hiroshi Kayakiri, Naoaki Fujii, Hitoshi Hamashima, Minoru Sakurai, Kenichi Washizuka, Yasuyo Tomishima, Kiyoshi Taniguchi, Naoko Unami, Yutaka Kono, Hirofumi Ishikawa, Nobuhiro Yamamoto, Hisashi Mimura
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Patent number: 6437146Abstract: Oxazole compounds of formula (I), wherein R1 is aryl which may be substituted with halogen(s), R2 is aryl which may be substituted with halogen(s), X is single bond, (a) or SO2, R3 and R4 are independently hydrogen or suitable substituent, (wherein X is (a), neither R3 nor R4 is hydrogen), R3 and R4 may be linked together to form (b), (b) is N-containing heterocyclic group which may be substituted with one or more suitable substituent(s), R5 is hydrogen, etc., A1 is lower alkylene or single bond, (c) is cyclo(C3-C9)alkane or cyclo(C5-C9)alkene, or a pro-drug thereof, or a pharmaceutically acceptable salt thereof, which are useful as medicament.Type: GrantFiled: April 20, 2001Date of Patent: August 20, 2002Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kouji Hattori, Akira Tanaka, Yutaka Kono, Shoko Nakazato
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Patent number: 6262296Abstract: A polyisocyanate prepolymer with isocyanate group on terminal obtainable by reaction of (A) polyoxyalkylenepolyol, (B) polyhydric alcohol having a molecular weight of 90 to 250 and the number of hydroxyl group of 2 to 3 with branched alkyl group and/or cyclohexane ring and (C) organic polyisocyanate composed of bis(isocyanatemethyl)cyclohexane, wherein NCO group content in the polyisocyanate prepolymer is 8% by weight or above and urethane group content in the polyisocyanate prepolymer is 8% by weight or above and sum total of NCO group content and urethane group content is 16 to 30% by weight and a concentration of unreacted (C) organic polyisocyanate remained in the polyisocyanate prepolymer is 1% by weight or below.Type: GrantFiled: April 14, 2000Date of Patent: July 17, 2001Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Takeshi Nomura, Takeshi Koyama, Yutaka Kono
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Patent number: 4087980Abstract: This invention relates to a safety submarine spherical air chamber made of a flexible material wherein persons are able to observe the undersea condition and the seabed from the scientific or recreational point of view by maintaining the atmospheric pressure of the above spherically expanded chamber approximately equivalent to the sea water pressure therearound, and then by floating therein a floating base on which they can stay.Type: GrantFiled: August 23, 1976Date of Patent: May 9, 1978Inventor: Yutaka Kono
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Patent number: D277577Type: GrantFiled: November 1, 1982Date of Patent: February 12, 1985Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Tadashi Sumino, Toshihiro Iyama, Yutaka Kono, Akishige Sai, Fumioki Ichihara
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Patent number: D289154Type: GrantFiled: September 27, 1984Date of Patent: April 7, 1987Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Kuniyuki Kawamoto, Yutaka Kono, Akishige Sai
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Patent number: D295862Type: GrantFiled: October 17, 1984Date of Patent: May 24, 1988Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Hiroshi Yonekura, Yutaka Kono
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Patent number: D378084Type: GrantFiled: March 13, 1996Date of Patent: February 18, 1997Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Takayuki Hayami, Tetsuya Imamura, Yutaka Kono, Makoto Fujita
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Patent number: D412317Type: GrantFiled: September 2, 1998Date of Patent: July 27, 1999Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Toshio Horiki, Tetsuji Abe, Yutaka Kono