Patents by Inventor Yutaka Ohbuchi
Yutaka Ohbuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120322807Abstract: The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: Wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a groupType: ApplicationFiled: June 18, 2012Publication date: December 20, 2012Inventors: Kazuo Sekiguchi, Takashi Suzuki, Yutaka Ohbuchi, Mitsuhiro Okuno, Naoto Ohi, Kenji Ohnishi, Masaaki Motoyama, Kenji Yoshida, Takeshi Kodama, Kazuhisa Sugiyama, Seiji Akamatsu, Kunihiko Kiyono, Yasuo Yanagihara, Takashi Watanabe, Kazuhiko Hayashi, Hideo Tanaka, Takumi Sumida
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Patent number: 8263599Abstract: An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.Type: GrantFiled: October 2, 2007Date of Patent: September 11, 2012Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Kazuo Sekiguchi, Takashi Suzuki, Yutaka Ohbuchi, Mitsuhiro Okuno, Naoto Ohi, Kenji Ohnishi, Masaaki Motoyama, Kenji Yoshida, Takeshi Kodama, Kazuhisa Sugiyama, Seiji Akamatsu, Kunihiko Kiyono, Yasuo Yanagihara, Takashi Watanabe, Kazuhiko Hayashi, Hideo Tanaka, Takumi Sumida
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Publication number: 20100261880Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: ApplicationFiled: September 30, 2008Publication date: October 14, 2010Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: MASATO HORIE, KEIICHI OKUTOMI, YOSHIHIRO TANIGUCHI, MIKIO SUZUKI, YUTAKA OHBUCHI
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Publication number: 20100210661Abstract: An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.Type: ApplicationFiled: October 2, 2007Publication date: August 19, 2010Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Kazuo Sekiguchi, Takashi Suzuki, Yutaka Ohbuchi, Mitsuhiro Okuno, Naoto Ohi, Kenji Ohnishi, Masaaki Motoyama, Kenji Yoshida, Takeshi Kodama, Kazuhisa Sugiyama, Seiji Akamatsu, Kunihiko Kiyono, Yasuo Yanagihara, Takashi Watanabe, Kazuhiko Hayashi, Hideo Tanaka, Takumi Sumida
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Patent number: 7582732Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SEQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: GrantFiled: July 3, 2008Date of Patent: September 1, 2009Assignee: Osaka Pharmaceutical Co., Ltd.Inventors: Masato Horie, Keiichi Okutomi, Yoshihiro Taniguchi, Mikio Suzuki, Yutaka Ohbuchi
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Publication number: 20090017479Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SEQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: ApplicationFiled: February 15, 2008Publication date: January 15, 2009Inventors: Masato HORIE, Keiichi Okutomi, Yoshihiro Taniguchi, Mikio Suzuki, Yutaka Ohbuchi
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Publication number: 20080275218Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SEQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: ApplicationFiled: July 3, 2008Publication date: November 6, 2008Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Masato HORIE, Keiichi Okutomi, Yoshihiro Taniguchi, Mikio Suzuki, Yutaka Ohbuchi
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Patent number: 7432363Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: GrantFiled: December 23, 2003Date of Patent: October 7, 2008Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Masato Horie, Keiichi Okutomi, Yoshihiro Taniguchi, Mikio Suzuki, Yutaka Ohbuchi
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Publication number: 20040254340Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: ApplicationFiled: December 23, 2003Publication date: December 16, 2004Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Masato Horie, Keiichi Okutomi, Yoshihiro Taniguchi, Mikio Suzuki, Yutaka Ohbuchi
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Patent number: 5363652Abstract: An engine including a supercharger wherein a waste gate valve is provided in the bypass passage bypassing the exhaust turbine of the supercharger and the supercharged pressure is controlled by the waste gate valve so that when the opening of the throttle valve provided in the intake duct falls under a set level, the air-fuel mixture is made lean and when it becomes greater than the set opening, the air-fuel mixture is made rich. When the air-fuel mixture is changed from a lean to rich mixture, the opening of the waste gate valve is made larger to reduce the supercharged pressure and thereby prevent abrupt fluctuations in the engine output.Type: GrantFiled: June 14, 1993Date of Patent: November 15, 1994Assignee: Toyota Jidosha Kabushiki KaishaInventors: Shigetaka Tanaka, Yukio Ohtake, Yutaka Ohbuchi