Patents by Inventor Yutaka Ohuchi
Yutaka Ohuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6426331Abstract: Compounds, compositions and methods that are useful in the treatment of immunoregulatory conditions and disorders are provided herein. In particular, the invention provides compounds which modulate the function of a Signal Transducer and Activator of Transcription (STAT) protein. The compounds are represented by the general formula: wherein Y, Ar, X, A2, A1, R1 and R2 are defined herein. The compounds are useful to treat, for example, allergic and inflammatory conditions and disorders.Type: GrantFiled: July 7, 1999Date of Patent: July 30, 2002Assignee: Tularik Inc.Inventors: Judi McKinney, Brian C. Raimundo, Timothy D. Cushing, Hiromitsu Yoshimura, Yutaka Ohuchi, Akira Hiratate, Hiroshi Fukushima
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Patent number: 5753673Abstract: Quinolinecarboxylic acid derivatives represented by the following formula: ##STR1## wherein C is hydroxymethyl, methoxy, ethoxy or morpholinyl, or pharmaceutically acceptable salts thereof exhibit a potent action for stimulating a serotonin 4 receptor. The compounds exhibit an action of enhancing the gastrointestinal motor function to improve the gastrointestinal conditions such as heartburn, anorexia, bowel pain, abdominal distension, etc., accompanied by chronic gastritis, diabetes mellitus or postoperative gastroparesis, and are thus effective for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction and constipation.Type: GrantFiled: January 18, 1996Date of Patent: May 19, 1998Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Yutaka Ohuchi, Masaji Suzuki, Hajime Asanuma, Sadakazu Yokomori, Katsuo Hatayama
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Patent number: 5733917Abstract: Endo-(8-methyl-8-azabicyclo?3.2.1!oct-3-yl) 1-isopropyl-2(1H)-quinolone-3-carboxylate represented by Formula (I): ##STR1## or an acid addition salt thereof acts on a serotonin 4 receptor thereby to have a serotonin-like receptor stimulating activity, therefore has an action on activating gastrointestinal motor functions and thus is effective for the improvement of gastrointestinal conditions such as heartburn, anorexia, bowel pain or abdominal distension accompanied by chronic gastritis or postoperative gastroparesis, and further for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction or constipation.Type: GrantFiled: August 21, 1996Date of Patent: March 31, 1998Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Yutaka Ohuchi, Masaji Suzuki, Hajime Asanuma, Sadakazu Yokomori, Katsuo Hatayama, Yoshihiko Isobe, Haruko Kijima, Makoto Muramatsu
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Patent number: 5571820Abstract: Endo-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1 -isopropyl-2(1H)-quinolone-3-carboxamide shown by formula (I): ##STR1## or an acid addition salt thereof exhibits a potent action for stimulating a serotonin 4 receptor and is effective for the treatment of diseases and for the improvement of conditions, caused by a reduced motility in the gastrointestinal tract.Type: GrantFiled: April 28, 1995Date of Patent: November 5, 1996Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Yutaka Ohuchi, Masaji Suzuki, Hajime Asanuma, Sadakazu Yokomori, Katsuo Hatayama, Yoshihiko Isobe, Chika Ito, Makoto Muramatsu
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Patent number: 4885367Abstract: Sulfonanilide compounds represented by the formula ##STR1## wherein R.sup.1 is a lower alkyl group or a trifluoromethyl group, R.sup.2 is a cycloalkylidenemethyl group, a group of the formula --A--R.sup.3 (wherein A is an oxygen atom, a sulfur atom, a sulfynyl group or a sulfinyl group and R.sup.3 is a cycloalkyl group having 5-8 carbon atoms; a cycloalkyl group having 5-8 carbon atoms substituted by one or two of a lower alkyl group, an oxo group, a hydroxyl group or a methanesulfonyloxy group, a tetrahydropyranyl group; a tetrahydrothiopyranyl group; or a 1-methyl-piperidyl group) or a group of the formula --B--R.sup.4 (wherein B is a carbonyl group, a hydroxymethylene group or a methylene group, R.sup.4 is a cycloalkyl group having 5-8 carbon atoms) and the pharmaceutically acceptable salts thereof have anti-inflammatory activity.Type: GrantFiled: November 16, 1988Date of Patent: December 5, 1989Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kensei Yoshikawa, Yutaka Ohuchi, Kazuto Sekiuchi, Shiuji Saito, Katsuo Hatayama, Kaoru Sota
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Patent number: 4557871Abstract: Novel styrene derivatives of the general formula ##STR1## wherein X is hydrogen or halogen, X.sup.1 is halogen, R is hydrogen or methyl, Y is hydroxymethyl, carboxyl, --COOR.sup.1 or --COR.sup.2 wherein R.sup.1 is prenyl, geranyl, farnesyl, cyclohexyl, phthalidyl, straight or branched chain alkyl having 1 to 6 carbon atoms, or said alkyl substituted with hydroxy, methoxy, pyridyl or alkanoyloxy having 2 to 16 carbon atoms, and R.sup.2 is amino, hydroxyamino mono-(or di-)alkylamino in which the alkyl moiety contains 1 or 2 carbon atoms, ethoxycarbonylmethylamino, carboxymethylamino, thiazolylamino, cyclohexylamino, pyridylamino, morpholino, N-methylpiperazino, phenylamino, phenylamino substituted with one or two of halogen, hydroxy, methyl, methoxy, trifluoromethyl or carboxyl at the phenyl ring, and the pharmaceutically acceptable salts thereof when Y is carboxyl are disclosed. These compounds exhibit high and long-lasting anti-inflammatory, analgesic and anti-pyretic activity.Type: GrantFiled: May 14, 1984Date of Patent: December 10, 1985Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Katsuo Hatayama, Kensei Yoshikawa, Tatsuhiko Sano, Yutaka Ohuchi, Tomomi Ota, Kazuto Sekiuchi, Kaoru Sota
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Patent number: 4436939Abstract: A process for producing 1-(p-prenylphenyl)ethanol, which comprises reacting p-chloroprenylbenzene with magnesium at a temperature between 100.degree. C. and 150.degree. C. to form a Grignard reagent, and then reacting it with acetaldehyde.Type: GrantFiled: August 25, 1982Date of Patent: March 13, 1984Assignees: Taisho Pharmaceutical Co., Ltd., Kuraray Co., Ltd.Inventors: Takehiro Amano, Kensei Yoshikawa, Tatsuhiko Sano, Yutaka Ohuchi, Michihiro Ishiguro, Manzo Shiono, Yoshiji Fujita, Takashi Nishida
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Patent number: 4433160Abstract: A process for producing an .alpha.-arylalkanoic acid ester represented by the general formula ##STR1## wherein Ar represents an aryl group which may optionally be substituted, and R.sup.1 and R.sup.2, independently from each other, represent a lower alkyl group,which comprises reacting a Grignard reagent prepared from an aryl halide of the general formulaAr--X.sup.1 (II)wherein Ar is as defined above and X.sup.1 represents a halogen atom,and magnesium, with an .alpha.-haloalkanoic acid ester of the general formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and X.sup.2 represents a halogen atom,said reaction of the Grignard reagent with the .alpha.-haloalkanoic acid ester of general formula (III) being carried out in the presence of a nickel compound.Type: GrantFiled: August 25, 1982Date of Patent: February 21, 1984Assignee: Taisho Pharmaceutical Company, Ltd.Inventors: Takehiro Amano, Kensei Yoshikawa, Tatsuhiko Sano, Yutaka Ohuchi, Michihiro Ishiguro, Manzo Shiono, Yoshiji Fujita, Takashi Nishida
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Patent number: 4420631Abstract: A novel carboxylic acid ester having the following general formula ##STR1## wherein R is alkoxyalkyl having 2 to 6 carbon atoms, cycloalkyl having 5 or 6 carbon atoms, tetrahydrofurfuryl, or alkyl having 1 to 6 carbon atoms optionally substituted with 1 or 2 hydroxyl groups, is a useful anti-inflammatory and analgesic agent.Type: GrantFiled: May 19, 1982Date of Patent: December 13, 1983Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Takehiro Amano, Toshihisa Ogawa, Kensei Yoshikawa, Yoshinori Shiobara, Tatsuhiko Sano, Yutaka Ohuchi, Tohru Tanami, Shoichi Ito, Jiro Sawada