Abstract: A spherical core containing an esomeprazole compound as an active ingredient and having a median particle diameter (d50) of 50 ?m or more is coated with a coat containing a controlled release layer to prepare a controlled release granule containing a controlled release granule with a median particle diameter (d50) of 350 ?m or less. The spherical core may contain the esomeprazole compound at a proportion of 50% by mass or more relative to the spherical core. The spherical core may be a spherical particle containing the esomeprazole compound as a drug. The spherical core has a median particle diameter (d50) of 50 ?m or more. The spherical core may have a sphericity of 0.6 or more. The coat may be in a multilayer free from an esomeprazole compound as an active ingredient. The controlled release layer may be an enteric coating layer. The proportion of the coat may be 80% by mass or more relative to the whole amount of the preparation.

Abstract: Masking particles which comprise a drug-containing particle containing a drug, an acid, and a carbonate, the drug-containing particle being coated with a coating layer containing a water-insoluble polymer sufficiently suppress drug release in the oral cavity and pharynx, rapidly release a drug after swallowing, and easily control the release suppression time of a drug. The acid may be at least one organic acid. The carbonate may be at least one water-soluble carbonate. Oral pharmaceutical compositions include tablets, granules, fine granules, powders.

Abstract: The main object is to provide a novel pharmaceutical solid preparation containing a pharmaceutically active ingredient, wherein the solid preparation is coated with a light shielding agent in a nano-order thickness. The present invention can include a pharmaceutical solid preparation containing at least one pharmaceutically active ingredient, wherein the surface of the solid preparation is coated with a light shielding agent or a metal oxide to a thickness in a range of 1 nm to 500 nm to form a coating layer, or is coated with a light shielding agent or a metal oxide which is present in a range of 5×10?6 mg/mm2 to 3×10?3 mg/mm2 to form a coating layer, and a process for producing a solid preparation containing at least one pharmaceutically active ingredient, comprising a step of coating a light shielding agent or a metal oxide by sputtering on the surface of the solid preparation to a thickness in a range of 1 nm to 500 nm.

Abstract: The present invention provides a method of efficiently manufacturing drug-containing particle which has a sharp peak in the particle size distribution, is highly spherical, and good in fluidity. The present invention relates to a manufacturing method of a drug-containing particle, the drug-containing particle comprising a raw material particle and a coating layer on the outside of the raw material particle, the raw material particle and/or the coating layer comprising at least one drug, wherein the manufacturing method comprises a granulation process that agitates a mixture comprising a core particle for powder coating formed by coating the raw material particle with a polymer and a drug and/or pharmaceutically acceptable additive while spraying a solvent which can dissolve the polymer on the mixture.

Abstract: An orally disintegrating tablet combinable with a variety of drugs and exhibits excellent disintegrating properties in an oral cavity but having strength and the like allowing ability to form a tablet. The annular orally disintegrating tablet containing a drug and a disintegrating agent; and having a hole in a central portion making it annular. The content of the disintegrating agent relative to total weight is 2% to 50% by weight. It exhibits excellent disintegrating properties, i.e., when a gradient of disintegrating time (seconds) of the tablet with respect to tableting pressure (kN) upon compression-forming is defined as “a” and a gradient of disintegrating time (seconds) of a disk-shaped orally disintegrating tablet with respect to tableting pressure (kN) upon compression-forming is defined as “b”, the disk-shaped orally disintegrating tablet having the same weight and external diameter as the annular orally disintegrating tablet the ratio (a/b) is 0.90 or less.

Abstract: An orally disintegrating tablet is disclosed possessing both advantageous hardness and disintegrability. The orally disintegrating tablet is (a) a compression molding product of a mixture comprising: a pharmaceutically active ingredient-containing composition selected from a group consisting of a pharmaceutically active ingredient-containing powder and pharmaceutically active ingredient-containing granules; rapidly disintegrating granules; and a lubricant, (b) wherein the rapidly disintegrating granules comprise a sugar and/or a sugar alcohol, and one or more organic and/or inorganic, hydrophilic and water-insoluble additives.

Abstract: Disclosed are orally disintegrating tablet having advantageous physical strength and disintegrability, and their method for production. The orally disintegrating tablet is a compression molding product of a mixture comprising granules A that contains a pharmaceutically active ingredient, and at least a disintegrant, wherein (a) the mean particle size of granules A is not greater than 300 ?m, (b) the particle distribution index for granules A is 3.0 or less, and (c) the angle of repose of granules A is not greater than 38 degrees.

Abstract: An orally disintegrating tablet is disclosed possessing both advantageous hardness and disintegrability. The orally disintegrating tablet is (a) a compression molding product of a mixture comprising: a pharmaceutically active ingredient-containing composition selected from a group consisting of a pharmaceutically active ingredient-containing powder and pharmaceutically active ingredient-containing granules; rapidly disintegrating granules; and a lubricant, (b) wherein the rapidly disintegrating granules comprise a sugar and/or a sugar alcohol, and one or more organic and/or inorganic, hydrophilic and water-insoluble additives.

Abstract: The present invention relates to a resistance welding method suitable for use in spot welding between a steel-base metal sheet, which has been plated for rust prevention purposes, and an aluminum-base metal sheet and aims to permit a current to flow at a high density across the plated steel sheet and the aluminum-clad steel sheet, thereby realizing high-quality welding.An aluminum-clad steel sheet comprised of a steel layer having projections and an aluminum layer is interposed between the plated steel sheet and the aluminum-base metal sheet to be welded to each other. An electrode is energized by a predetermined weld current from an alternating power supply. The current path is limited to the area of the projections, and metallic melt formed by melting of the plating is accommodated between the projections, preventing the current-carrying area from being increased.

Abstract: Disclosed is a concrete-filled steel bearing earthquake resistant wall which shows combined resistance to shearing forces exerted in the surface plane of an earthquake resistant wall. The wall comprises connecting members 1, a pair of surface steel plates 2 and 2' which are arranged in a parallel relationship to each other and secured by the connecting members 1 so that each space between these surface steel plates 2 is filled with the wall unit concrete 7, and wall unit periphery binding steel reinforcements 8 constructed from inverted U-shaped steel bars or similar material and arranged along the peripheral part of the wall unit concrete 7 at predetermined intervals so as to be fixed to said concrete 7. In addition, the slippage preventing members 6 are arranged in a staggered arrangement on the aforementioned surface steel plates 2 and 2'.

Abstract: A concrete-filled steel bearing earthquake resistant wall which has combined resistance to shearing forces exerted in the surface plane thereof has connecting members (1), a pair of surface steel plates (2 and 2') arranged in parallel spaced relationship to each other and secured by the connecting members (1) so that the space between these surface steel plates is filled with the wall unit concrete (7), and wall unit periphery binding steel reinforcements (8) constructed from inverted U-shaped steel bars or similar material and arranged along the peripheral part of the wall unit at predetermined intervals so as to be embedded in the concrete (7). Slippage preventing members (6) are arranged in a staggered arrangement on the aforementioned surface steel plates (2 and 2').

Abstract: In an apparatus for detecting the abnormality of a rotational speed sensor adapted for, for example, an anti-skid control system, a time period within which a subsequent pulse will be generated by the rotational speed sensor in response to the rotation of a body of revolution such as wheel is estimated on the basis of the latest pulse interval of the pulses previously generated therefrom and a value corresponding to the force of inertia of the wheel developed on the braking operation thereof. The determination of abnormality of the rotational speed sensor is made when the subsequent pulse is not produced within the estimated time period. This is arranged based on the fact that the pulse interval depends upon the inertial force of the wheel. With the above arrangement, the abnormality detection of the speed sensor can be quickly made, so that a fail-safe control in a braking system can be speedily performed in response to the occurrence of abnormality of the speed sensor.

Abstract: A printing aluminum alloy material plate is described which provides good printing characteristics, that is, surface-treatment ability, burning ability and ink stain resistivity; the plate is obtained from an aluminum alloy material which is cold-rolled at a reduction rate of from 20 to 95% after being subjected to intermediate annealing at a temperature of 300.degree. to 550.degree. C. wherein the aluminum alloy material comprises 0.25 wt % or less Si, from 0.05 to 1.0 wt % Fe, 0.03 wt % or less Cu, 0.10 wt % or less Ti, and 0.03 wt % or less Mg and the balance of unavoidable impurities and Al.

Abstract: A failure diagnosis system for a vehicle includes a failure detection means for detecting failures of devices or apparatuses installed in a vehicle, a storage means for storing failure information detected by the failure detection means, a failure display means for displaying failure information stored in the storage means, a time information means for adding failure information detected by the failure detection means and stored in the storage means to time information showing the time when the failure information is detected, a retrieval time input means for inputting a retrieval time and a selective display means for displaying selectively failure information which has time information being within the retrieval time.

Abstract: In an anti-skid control system for a motor vehicle there is provided a fail-safe control system for providing a compensation for a proper vehicle braking operation against the occurrence of failure of a hydraulic pressure control valve. The fail-safe control system includes a device for monitoring a control signal for controlling the operation of the control valve so that the hydraulic pressure applied to a wheel braking cylinder is regulated for preventing a wheel of the vehicle from skidding. The monitoring device detects the occurrence of failure of the control valve when the control signal indicative of one of the operation modes of the control valve is continuously generated more than a predetermined time period.

Abstract: A multiple signal transmitting apparatus for automobiles includes a plurality of switches mounted on the steering wheel of an automobile, a multiplexing circuit mounted on the steering wheel for multiplexing the output signals of the switches, at least one light-emitting device mounted on a moving part rotatable together with the steering wheel so as to be arranged on a circumference lying in a plane perpendicular to the central axis of rotation of the steering wheel and concentric with the central axis of rotation to generate a light signal in response to the multiplexed output signal of the multiplexing circuit, at least one light-sensitive device mounted on the surface of the steering wheel bearing portion facing the light-emitting device to receive the light signal from the light-emitting device and generate an output signal, and a decoder circuit mounted on the body portion of the automobile to decode the output signal of the light-sensitive device to generate signals corresponding to the output signals

Abstract: A method of and an apparatus for indicating a remaining fuel quantity for vehicles, designed to digitally indicate the quantity of fuel remaining in the fuel tank of a vehicle. The method of and the apparatus for repeating the operations of performing sampling detection of an amount of fuel remaining in the fuel tank of a vehicle, determining a center value for a plurality of remaining fuel quantity values detected by a microcomputer, determining limit values each thereof being apart from the center value by a predetermined amount, using any subsequent detected value exceeding the limit values as a new limit value, computing an average value of a predetermined number of detected sampling values, and indicating it on a display.