Abstract: A method for producing CD4/CD8 double-positive T cells, comprising the steps of: (1) culturing pluripotent stem cells in a medium to induce hematopoietic progenitor cells; and (2) culturing the hematopoietic progenitor cells obtained in the step (1) in a medium containing a p38 inhibitor and/or SDF-1 to induce CD4/CD8 double-positive T cells.

Abstract: The present invention provides a medicinal composition containing a T cell population that exhibits an excellent antigen specificity and has genetic diversity, and a method for preventing or treating cancer using the medicinal composition.

Abstract: The present invention provides a method for producing a regenerated T cell population via iPS cells, wherein the said regenerated T cell population maintains the repertoire diversity of a T cell population before initialization and has specificity to an antigen. The method comprises steps of (1) bringing a T cell population into contact with one or more tumor-related antigens, or a biological tissue containing one or more tumor-related antigens, or a crushed material or a lysate thereof, and enriching the T cell population having specificity to the tumor-related antigens, (2) initializing the enriched T cell population to iPS cells, and culturing while maintaining the repertoire diversity of the enriched T cell population, and (3) producing a regenerated T cell population from the cultured iPS cells.

Abstract: The present invention relates to a method for producing antigen-specific T cells, the antigen-specific T cells produced by the method, and a pharmaceutical composition containing the antigen-specific T cells.

Abstract: [Problem] To provide a method for producing a population of genetically diverse regenerated T cells via iPS cells, and to provide said population of regenerated T cells. [Solution] A method for producing a population of genetically diverse regenerated T cells via iPS cells, including: (1) obtaining a population of T cells that can recognize a target tissue or antigens from a population of the genetically diverse T cells; (2) reprogramming the obtained the population of T cells into iPS cells, culturing the iPS cells while maintaining genetic diversity; and (3) producing a population of the genetically diverse regenerated T cells from the iPS cells.

Abstract: The present invention provides a method for efficiently inducing CD8-positive T cells by adding vitamin C to the medium in the steps of induction of the CD8-positive T cells from pluripotent stem cells. The present invention also provides a method for efficiently inducing CD8-positive T cells by performing culture in a medium supplemented with an adrenocortical hormone agent in the step of induction of the CD8-positive T cells from CD4/CD8 double-positive T cells.

Abstract: A method for producing CD4/CD8 double-positive T cells, comprising the steps of: (1) culturing pluripotent stem cells in a medium to induce hematopoietic progenitor cells; and (2) culturing the hematopoietic progenitor cells obtained in the step (1) in a medium containing a p38 inhibitor and/or SDF-1 to induce CD4/CD8 double-positive T cells.

Abstract: A method for producing differentiated cells from pluripotent stem cells by an embryoid body (EB) method, including the steps of: (1) culturing pluripotent stem cells by using a culture bag having a perfluoropolymer on its inner surface to thereby form an embryoid body; and (2) inducing differentiation of the pluripotent stem cells contained in the embryoid body obtained in step (1) to thereby obtain differentiated cells.

Abstract: The present invention provides a method for efficiently inducing CD8-positive T cells by adding vitamin C to the medium in the steps of induction of the CD8-positive T cells from pluripotent stem cells. The present invention also provides a method for efficiently inducing CD8-positive T cells by performing culture in a medium supplemented with an adrenocortical hormone agent in the step of induction of the CD8-positive T cells from CD4/CD8 double-positive T cells.

Abstract: An information provider instructs a server system of an information distribution region and attributes of service users, monitors, based upon position information from service users, the state of distribution of service users who have the above-mentioned attributes and are present in the information distribution region designated by the information provider, and distributes prescribed information to mobile information terminals of the service users based upon the state of distribution of the service users.

Abstract: The art relates to information distribution service providing technology. The server system predicts the distribution state of mobile information terminals in the future, based on the location information of mobile information terminals and change over time in the distribution state of service users (mobile information terminals) with a specific user characteristic in an information distribution object area. Based on the prediction, the server system carries out information distribution. This makes it possible to improve information distribution efficiency.

Abstract: A radio tag system including at least one radio tag that includes a plurality of data areas and a key storage area that stores key information corresponding to at least one data area; and a managing unit that manages access to the radio tag, and that includes a request receiving unit that receives from a user, a request to issue key information that allows access to one of the data areas, and an issuing unit that issues the key information in response to the request received.

Abstract: An information provider instructs a server system of an information distribution region and attributes of service users, monitors, based upon position information from service users, the state of distribution of service users who have the above-mentioned attributes and are present in the information distribution region designated by the information provider, and distributes prescribed information to mobile information terminals of the service users based upon the state of distribution of the service users.

Abstract: The present invention provides a release material formed by irradiating a release material precursor having a shear storage modulus of about 1×102 to about 3×106 Pa at 20° C. and a frequency of 1 Hz, wherein the release material has a contact angle of 15° or more, measured using a mixed solution of methanol and water (volume ratio: 90/10) having a wet tension of 25.4 mN/m. The release material of the present invention has improved anchoring to certain substrates, ensuring relatively low release strength from certain pressure-sensitive adhesives, particularly even after the exposure to a high temperature. Thus, the release materials are capable of allowing the pressure-sensitive adhesive to maintain stable residual adhesion strength.

Abstract: The present invention provides a release material formed by irradiating a release material precursor having a shear storage modulus of about 1×102 to about 3×106 Pa at 20° C. and a frequency of 1 Hz, wherein the release material has a contact angle of 15° or more, measured using a mixed solution of methanol and water (volume ratio: 90/10) having a wet tension of 25.4 mN/m. The release material of the present invention has improved anchoring to certain substrates, ensuring relatively low release strength from certain pressure-sensitive adhesives, particularly even after the exposure to a high temperature. Thus, the release materials are capable of allowing the pressure-sensitive adhesive to maintain stable residual adhesion strength.

Abstract: The server system comprises a data base for storing the information of a specific area where the information distribution service is provided to registered users of the portable mobile information terminals, the prepared information to be distributed and the distribution conditions thereof provided by a sponsor, and each registered user and the conditions for receiving the prepared information. The position information is received from a portable mobile information terminal, and it is determined whether the portable mobile information terminal is located in the specific area and, in the case where the portable mobile information terminal is located in the specific area, individual and specific information satisfying both the distribution conditions and the receiving conditions are distributed to the particular portable mobile information terminal.