Abstract: The present disclosure relates to an imaging system and method. Specifically, an imaging system comprises: a positioning image acquisition unit, configured to acquire a positioning image of a scanning object; a monitoring slice image acquisition unit, configured to determine a key point corresponding to the position of a target region of interest in the positioning image by using a neural network, and acquire a monitoring slice image of the scanning object at the position of the key point; and a target region-of-interest segmentation unit, configured to segment the monitoring slice image to obtain the target region of interest. The present disclosure can accurately acquire the position of the monitoring slice, and can accurately obtain the target region of interest through segmentation by a cascaded coarse segmentation and fine segmentation.