Patents by Inventor Yuuhei ARAI
Yuuhei ARAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12234485Abstract: Provided is a resin film having excellent cell extensibility in cell culture. The resin film formed of a scaffold material for cell culture containing a synthetic resin, the resin film having a compressive modulus of 5.5 GPa or more at a frequency of 1 Hz as measured using a nanoindenter device in ion-exchanged water in accordance with ISO14577-1 after being immersed in the ion-exchanged water at 37° C. for 24 hours.Type: GrantFiled: May 27, 2020Date of Patent: February 25, 2025Assignee: SEKISUI CHEMICAL CO., LTD.Inventors: Yuuhei Arai, Ryoma Ishii, Hiroki Iguchi, Satoshi Haneda
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Publication number: 20250051721Abstract: Provided is a scaffold material for cell culture with which the culture stability of cells can be maintained over an extended period of time. A scaffold material for cell culture according to the present invention contains a peptide-conjugated (meth)acrylic copolymer having a (meth)acrylic copolymer moiety and a peptide moiety bonded to the (meth)acrylic copolymer moiety, the following relaxation time (CS2) being 5 milliseconds or less. Relaxation time (CS2): a relaxation time of a CS component, which is a component having the lowest molecular mobility among three components, when the scaffold material for cell culture after being brought into contact with heavy water at 25° C. for 18 hours is measured by a CPMG method using pulsed NMR, and the obtained free induction decay curve of spin-spin relaxation of 1H is separated into three components.Type: ApplicationFiled: December 26, 2022Publication date: February 13, 2025Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Yuuhei ARAI, Nami NAKAJIMA
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Publication number: 20250051722Abstract: Provided is a coating solution for forming a cell scaffold with which a cell scaffold having a large thickness can be easily formed and the proliferation of cells can be enhanced. A coating solution for forming a cell scaffold according to the present invention contains a peptide-conjugated resin having a synthetic resin moiety and a peptide moiety and an alcohol solvent, a content of the peptide-conjugated resin being 0.1 wt % or more.Type: ApplicationFiled: December 26, 2022Publication date: February 13, 2025Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Daigo KOBAYASHI, Yuuhei ARAI
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Publication number: 20250043241Abstract: Provided is a scaffold material for cell culture with which the culture stability of cells can be maintained over an extended period of time. A scaffold material for cell culture according to the present invention contains a peptide-conjugated (meth)acrylic copolymer having a (meth)acrylic copolymer moiety and a peptide moiety bonded to the (meth)acrylic copolymer moiety, when the peptide-conjugated (meth)acrylic copolymer is subjected to high performance liquid chromatography measurement under the following condition 1, a peak top of a main peak having the largest area among signals being not detected within a retention time of 4 minutes: the condition 1 being: a column of C18 (Inner diameter 3.0 mm×length 150 mm, filler particle size 3.5 ?m), a column temperature of 40° C., a flow rate of 0.3 mL/min, a detector of an evaporative light scattering detector, a mobile phase A (liquid A) of a 0.Type: ApplicationFiled: December 26, 2022Publication date: February 6, 2025Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Yuuhei ARAI, Daigo KOBAYASHI, Yoshito ARAI
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Publication number: 20250011475Abstract: Provided is a coating solution for forming a cell scaffold with which a cell scaffold having a large thickness can be easily formed and the proliferation of cells can be enhanced. A coating solution for forming a cell scaffold according to the present invention contains a peptide-conjugated resin having a synthetic resin moiety and a peptide moiety and an alcohol solvent, a content of the peptide-conjugated resin being 0.1 wt % or more.Type: ApplicationFiled: September 10, 2024Publication date: January 9, 2025Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Daigo KOBAYASHI, Yuuhei ARAI
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Publication number: 20220348858Abstract: Provided is a cell culture scaffold material having excellent cell adhesion. The cell culture scaffold material according to the present invention contains a peptide-conjugated polyvinyl alcohol derivative having a polyvinyl alcohol derivative portion and a peptide portion, and the peptide portion has a cyclic peptide skeleton.Type: ApplicationFiled: May 15, 2020Publication date: November 3, 2022Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Daigo KOBAYASHI, Mayumi YUKAWA, Kenta TAKAKURA, Ryoma ISHII, Hiroki IGUCHI, Yuuhei ARAI, Satoshi HANEDA, Nobuhiko INUI
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Publication number: 20220325221Abstract: Provided is a cell culture scaffold material having excellent extensibility of pseudopodia and excellent cell proliferation. The cell culture scaffold material according to the present invention contains a peptide-conjugated polyvinyl alcohol derivative having a polyvinyl alcohol derivative portion and a peptide portion, and has a hydroxyl value of 1,100 mgKOH/g or less.Type: ApplicationFiled: May 15, 2020Publication date: October 13, 2022Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Kenta TAKAKURA, Mayumi YUKAWA, Daigo KOBAYASHI, Ryoma ISHII, Hiroki IGUCHI, Yuuhei ARAI, Satoshi HANEDA, Nobuhiko INUI
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Publication number: 20220235307Abstract: Provided is a cell culture scaffold capable of allowing cell masses to be formed easily and efficiently. A cell culture scaffold according to the present invention includes a substrate; and a protrusion formed by patterning in a pattern of a dot or a line on the substrate, wherein the protrusion contains a synthetic resin, the synthetic resin contains at least a polyvinyl alcohol derivative or a poly(meth)acrylic resin, the protrusion has cell adhesion, and a portion of the protrusion located at the protrusion center position in plan view has an average height of 10 nm or more and 10 ?m or less.Type: ApplicationFiled: July 31, 2020Publication date: July 28, 2022Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Yuuhei ARAI, Nobuhiko INUI, Satoshi HANEDA, Hiroki IGUCHI
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Publication number: 20220228127Abstract: Provided is a resin film having excellent cell extensibility in cell culture. The resin film formed of a scaffold material for cell culture containing a synthetic resin, the resin film having a compressive modulus of 5.5 GPa or more at a frequency of 1 Hz as measured using a nanoindenter device in ion-exchanged water in accordance with ISO14577-1 after being immersed in the ion-exchanged water at 37° C. for 24 hours.Type: ApplicationFiled: May 27, 2020Publication date: July 21, 2022Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Yuuhei ARAI, Ryoma ISHII, Hiroki IGUCHI, Satoshi HANEDA
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Publication number: 20220227898Abstract: Provided is a resin film formed of a cell culture scaffold material, which has excellent fixation of cells after seeding and is capable of enhancing proliferation rate of cells. A resin film formed of a cell culture scaffold material, in which the cell culture scaffold material contains a synthetic resin, and the resin film has phase-separated structure including least a first phase and a second phase, and a ratio of the surface area of one of the first phase and the second phase to the entire surface is 0.01 or more and 0.95 or less.Type: ApplicationFiled: May 15, 2020Publication date: July 21, 2022Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Hiroki IGUCHI, Yuuhei ARAI, Nobuhiko INUI, Mayumi YUKAWA, Daigo KOBAYASHI, Yuuta NAKAMURA, Kenta TAKAKURA, Satoshi HANEDA, Ryoma ISHII
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Publication number: 20220177825Abstract: A scaffold material for cell culture having excellent cell colonization is provided. A scaffold material for cell culture according to the present invention includes a synthetic resin having a main chain and a graft chain, wherein the graft chain has a polydentate hydrogen-bonding group represented by the following formula (1) in a side chain: *—R-(Ai)n (1) wherein R represents a group having 50 or less carbon atoms, Ai represents an amino group, a carboxyl group, a hydroxyl group, a sulfone group, an imino group, or a thiol group, i represents a natural number, n represents an integer of two or more and four or less, and * represents a bonding position with another atom constituting the graft chain; and Ai may be identical or different from each other.Type: ApplicationFiled: March 27, 2020Publication date: June 9, 2022Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Hiroki IGUCHI, Yuuta NAKAMURA, Ryoma ISHII, Yuuhei ARAI, Satoshi HANEDA