Patents by Inventor Yuuichi Sugimoto

Yuuichi Sugimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DISPIROPYRROLIDINE DERIVATIVES
    Publication number: 20220106324
    Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
    Type: Application
    Filed: April 19, 2021
    Publication date: April 7, 2022
    Inventors: Yuuichi SUGIMOTO, Kouichi UOTO, Takanori WAKABAYASHI, Masaki MIYAZAKI, Masaki SETOGUCHI, Toru TANIGUCHI, Keisuke YOSHIDA, Akitake YAMAGUCHI, Shoko YOSHIDA
  • Crystals of dispiropyrrolidine derivatives
    Patent number: 10030030
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)—N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: July 24, 2018
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Shoko Yoshida, Yuuichi Sugimoto
  • Crystals of dispiropyrrolidine derivatives
    Patent number: 10023578
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)—N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: July 17, 2018
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Shoko Yoshida, Yuuichi Sugimoto
  • Crystals of Dispiropyrrolidine Derivatives
    Publication number: 20180155356
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)—N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 7, 2018
    Inventors: Shoko YOSHIDA, Yuuichi SUGIMOTO
  • CRYSTALS OF DISPIROPYRROLIDINE DERIVATIVES
    Publication number: 20180155355
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 7, 2018
    Inventors: Shoko YOSHIDA, Yuuichi SUGIMOTO
  • Crystals of dispiropyrrolidine derivatives
    Patent number: 9884871
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)—N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: February 6, 2018
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Shoko Yoshida, Yuuichi Sugimoto
  • Crystals of dispiropyrrolidine derivatives
    Patent number: 9745315
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4'S,5?R)—N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: August 29, 2017
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Shoko Yoshida, Yuuichi Sugimoto
  • Crystals of dispiropyrrolidine derivatives
    Patent number: 9718830
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: August 1, 2017
    Assignee: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Shoko Yoshida, Yuuichi Sugimoto
  • Crystals of dispiropyrrolidine derivatives
    Patent number: 9718831
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)—N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: August 1, 2017
    Assignee: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Shoko Yoshida, Yuuichi Sugimoto
  • Crystals of Dispiropyrrolidine Derivatives
    Publication number: 20170081337
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4'S,5?R)—N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Application
    Filed: December 6, 2016
    Publication date: March 23, 2017
    Inventors: Shoko YOSHIDA, Yuuichi SUGIMOTO
  • Crystals of Dispiropyrrolidine Derivatives
    Publication number: 20170081335
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Application
    Filed: December 6, 2016
    Publication date: March 23, 2017
    Inventors: Shoko YOSHIDA, Yuuichi SUGIMOTO
  • Crystals of Dispiropyrrolidine Derivatives
    Publication number: 20170081336
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)—N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Application
    Filed: December 6, 2016
    Publication date: March 23, 2017
    Inventors: Shoko YOSHIDA, Yuuichi SUGIMOTO
  • Crystals of Dispiropyrrolidine Derivatives
    Publication number: 20170081334
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)—N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Application
    Filed: December 6, 2016
    Publication date: March 23, 2017
    Inventors: Shoko YOSHIDA, Yuuichi SUGIMOTO
  • Crystals of dispiropyrrolidine derivatives
    Patent number: 9540386
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: January 10, 2017
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Shoko Yoshida, Yuuichi Sugimoto
  • Crystals of Dispiropyrrolidine Derivatives
    Publication number: 20160244458
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Application
    Filed: May 2, 2016
    Publication date: August 25, 2016
    Inventors: Shoko YOSHIDA, Yuuichi SUGIMOTO
  • Crystals of dispiropyrrolidine derivatives
    Patent number: 9359368
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)—N—[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro [cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: June 7, 2016
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Shoko Yoshida, Yuuichi Sugimoto
  • Crystals of Dispiropyrrolidine Derivatives
    Publication number: 20150210707
    Abstract: Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3?R,4?S,5?R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
    Type: Application
    Filed: September 5, 2013
    Publication date: July 30, 2015
    Inventors: Shoko Yoshida, Yuuichi Sugimoto
  • DISPIROPYRROLIDINE DERIVATIVES
    Publication number: 20140121196
    Abstract: A compound that inhibits interaction between, murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
    Type: Application
    Filed: November 14, 2013
    Publication date: May 1, 2014
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Yuuichi Sugimoto, Kouichi Uoto, Takanori Wakabayashi, Masaki Miyazaki, Masaki Setoguchi, Toru Taniguchi, Keisuke Yoshida, Akitake Yamaguchi, Shoko Yoshida
  • Dispiropyrrolidine derivatives
    Patent number: 8629133
    Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: January 14, 2014
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Yuuichi Sugimoto, Kouichi Uoto, Takanori Wakabayashi, Masaki Miyazaki, Masaki Setoguchi, Toru Taniguchi, Keisuke Yoshida, Akitake Yamaguchi, Shoko Yoshida
  • DISPIROPYRROLIDINE DERIVATIVES
    Publication number: 20130165424
    Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
    Type: Application
    Filed: March 9, 2012
    Publication date: June 27, 2013
    Inventors: Yuuichi Sugimoto, Kouichi Uoto, Takanori Wakabayashi, Masaki Miyazaki, Masaki Setoguchi, Toru Taniguchi, Keisuke Yoshida, Akitake Yamaguchi, Shoko Yoshida