Patents by Inventor Yuuki Hatakeyama
Yuuki Hatakeyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10137234Abstract: The invention provides a method for sterilizing a blood purifier, as well as a blood purifier package. The method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and is highly reliable in safety when employed for hemocatharsis therapy. The method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.Type: GrantFiled: May 27, 2015Date of Patent: November 27, 2018Assignee: NIPRO CORPORATIONInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9987408Abstract: Objects of the invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.Type: GrantFiled: May 27, 2015Date of Patent: June 5, 2018Assignee: NIPRO CORPORATIONInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9987409Abstract: The invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The blood purifier comprises selectively permeable separation membranes as a main component and is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.Type: GrantFiled: May 27, 2015Date of Patent: June 5, 2018Assignee: NIPRO CORPORATIONInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Publication number: 20150320921Abstract: The invention provides a method for sterilizing a blood purifier, as well as a blood purifier package. The method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and is highly reliable in safety when employed for hemocatharsis therapy. The method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.Type: ApplicationFiled: May 27, 2015Publication date: November 12, 2015Applicant: NIPRO CORPORATIONInventors: Takashi SUNOHARA, Yuuki HATAKEYAMA, Noriko MONDEN, Toshiaki MASUDA, Noriaki KATO, Kimihiro MABUCHI
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Publication number: 20150258265Abstract: Objects of the invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.Type: ApplicationFiled: May 27, 2015Publication date: September 17, 2015Applicant: NIPRO CORPORATIONInventors: Kimihiro MABUCHI, Noriko MONDEN, Noriaki KATO, Yuuki HATAKEYAMA, Takashi SUNOHARA, Toshiaki MASUDA
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Publication number: 20150258264Abstract: The invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The blood purifier comprises selectively permeable separation membranes as a main component and is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.Type: ApplicationFiled: May 27, 2015Publication date: September 17, 2015Applicant: NIPRO CORPORATIONInventors: Kimihiro MABUCHI, Noriko MONDEN, Noriaki KATO, Yuuki HATAKEYAMA, Takashi SUNOHARA, Toshiaki MASUDA
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Patent number: 9067178Abstract: Objects of the present invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.Type: GrantFiled: December 2, 2005Date of Patent: June 30, 2015Assignee: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9056280Abstract: The present invention provides a method for sterilizing a blood purifier, which method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and which method is highly reliable in safety when employed for hemocatharsis therapy. The present invention also provides a blood purifier package. The present invention relates to a method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, and this method is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.Type: GrantFiled: October 13, 2005Date of Patent: June 16, 2015Assignee: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9050410Abstract: The present invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The present invention relates to a blood purifier which comprises selectively permeable separation membranes as a main component and which is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.Type: GrantFiled: October 13, 2005Date of Patent: June 9, 2015Assignee: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 7837042Abstract: The invention relates to a hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of the membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of the membrane. The hollow fiber membrane module is exposed to a radioactive ray, on condition that the oxygen concentration of an ambient atmosphere around the hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of the hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %.Type: GrantFiled: August 9, 2005Date of Patent: November 23, 2010Assignee: Nipro CorporationInventors: Hideyuki Yokota, Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Publication number: 20080142434Abstract: Objects of the present invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.Type: ApplicationFiled: December 20, 2005Publication date: June 19, 2008Applicant: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Publication number: 20080087599Abstract: The present invention provides a method for sterilizing a blood purifier, which method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and which method is highly reliable in safety when employed for hemocatharsis therapy. The present invention also provides a blood purifier package. The present invention relates to a method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, and this method is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.Type: ApplicationFiled: October 13, 2005Publication date: April 17, 2008Applicant: NIPRO CORPORATIONInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Publication number: 20080067122Abstract: The present invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The present invention relates to a blood purifier which comprises selectively permeable separation membranes as a main component and which is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.Type: ApplicationFiled: October 13, 2005Publication date: March 20, 2008Applicant: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Publication number: 20080044643Abstract: The invention relates to a hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of the membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of the membrane. The hollow fiber membrane module is exposed to a radioactive ray, on condition that the oxygen concentration of an ambient atmosphere around the hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of the hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %.Type: ApplicationFiled: August 9, 2005Publication date: February 21, 2008Applicant: Nipro CorporationInventors: Hideyuki Yokota, Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Publication number: 20080000830Abstract: The present invention relates to a highly water-permeable hollow fiber membrane type blood purifier which comprises hydrophobic polymer hollow fiber membranes each containing a hydrophilic polymer, wherein the hollow fiber membrane has a hydrophilic polymer content of 25 to 50 mass % and a ratio of hole areas of 8 to 25% at its outer surface, and has a thickness non-uniformity degree of 0.6 or more, a thickness of 10 to 60 ?m and a burst pressure of 0.5 to 2 MPa, and which is characterized in that the blood purifier has a water permeability of 150 to 2,000 ml/m2/hr/mmHg, and in that said blood purifier is exposed to radioactive rays on conditions that the oxygen concentration of an ambient atmosphere around the hollow fiber membranes is from 0.001% inclusive to 0.1% inclusive, and that the moisture content of the hollow fiber membrane to its weight is from 0.2 mass % inclusive to 7 mass % inclusive. The present invention also relates to a process for manufacturing the same-blood purifier.Type: ApplicationFiled: August 8, 2005Publication date: January 3, 2008Inventors: Kimihiro Mabuchi, Hideyuki Yokota, Noriko Monden, Shinya Koyama, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda