Abstract: A signal detection circuit detects, as a detection target signal, a signal of a main terminal of a switching element by comparing the detection target signal with a reference signal. The signal detection circuit includes: a signal generation unit generating the reference signal; a first capacitor having a first terminal connected with the main terminal of the switching element; a second capacitor having a first terminal connected with an output terminal of the signal generation unit; and a detection circuit receiving, as input signals, a signal output from a second terminal of the first capacitor and a signal output from a second terminal of the second capacitor, and the detection circuit detecting the detection target signal based on the input signals.

Abstract: Provided is a cell culture microcarrier capable of suppressing the aggregation of a microcarrier due to cell clumps and enhancing the efficiency of culturing cells. The cell culture microcarrier according to the present invention includes a base particle and a coating layer coating the outer surface of the base particle, and has a specific gravity of 1.10 g/cm3 or more.

Abstract: A drive circuit drives a switch configuring a power converter. The drive circuit divides an inter-terminal voltage of a switch. The drive circuit includes a differential circuit having first and second input terminals to which the divided inter-terminal voltages are inputted. The differential circuit outputs an analog voltage based on a voltage difference between the input terminals. The differential circuit executes reset of the output voltage, and with the voltage difference when reset is canceled after reset is executed as a reference voltage, outputs an analog voltage in which an amount of change from the reference voltage is multiplied by an amplification factor. The drive circuit outputs a binary signal based on comparison results between a threshold and the analog voltage outputted from the differential circuit, and sets a transfer rate of a gate charge of the switch when a driving state is switched, based on the output signal thereof.

Abstract: A signal detection circuit includes: a first capacitor having a first terminal connected with a first main terminal of a switching element; a second capacitor having a first terminal connected with a second main terminal of the switching element; and a detection circuit having a differential circuit configuration. The detection circuit receives, as input signals, a signal from a second terminal of the first capacitor and a signal from a second terminal of the second capacitor, detects detection target signals based on the input signals. The detection target signals include a signal of the first main terminal of the switching element and a signal of the second main terminal of the switching element.

Abstract: In a pulse edge detection circuit, a measurement circuit has a comparator provided therein which compares a voltage with a reference voltage and outputs a pulse signal. An RSFF puts a signal in a high level at a timing at which detecting a rise edge due to a change of the pulse signal to the high level. In such manner, a set signal of an RSFF becomes inactive and a reset signal of the RSFF becomes active, and a fall edge of the pulse signal becomes detectable. When a fall edge is generated due to a change of the pulse signal from the high level to the low level, the set signal of the RSFF becomes active, and a signal becomes high level.

Abstract: Provided is a formulation that can improve all of transdermal absorbability of an active ingredient, immediate effect in transdermal absorption, and reduction of skin irritation, to high levels. A formulation containing: a base; and a core-shell structure having a core portion containing an active ingredient and a shell portion containing a surfactant; in which the core portion is a solid, the surfactant contains a compound having two or more fatty acid bonds and a compound having one fatty acid bond, and a proportion of the compound having two or more fatty acid bonds in the surfactant is 5% by weight or more and 75% by weight or less.

Abstract: Provided is a resin film formed of a cell culture scaffold material, which has excellent fixation of cells after seeding and is capable of enhancing proliferation rate of cells. A resin film formed of a cell culture scaffold material, in which the cell culture scaffold material contains a synthetic resin, and the resin film has phase-separated structure including least a first phase and a second phase, and a ratio of the surface area of one of the first phase and the second phase to the entire surface is 0.01 or more and 0.95 or less.

Abstract: Provided is a core-shell structure that can achieve both improvement in transdermal absorption of an active ingredient and reduction in skin irritation at a high level. A core-shell structure 10 includes: a core portion 11 containing an active ingredient, the core portion being solid; and a shell portion 12 containing both a first surfactant having a melting point of less than 35° C. and a second surfactant having a melting point of 35° C. or more, the first surfactant and the second surfactant each having an HLB value of 4 to 14, the first surfactant and the second surfactant each containing at least one selected from the group consisting of sorbitan fatty acid esters, glycerin fatty acid esters, propylene glycol fatty acid esters, and fatty acid alkanolamides.

Abstract: A scaffold material for cell culture having excellent cell colonization is provided. A scaffold material for cell culture according to the present invention includes a synthetic resin having a main chain and a graft chain, wherein the graft chain has a polydentate hydrogen-bonding group represented by the following formula (1) in a side chain: *—R-(Ai)n (1) wherein R represents a group having 50 or less carbon atoms, Ai represents an amino group, a carboxyl group, a hydroxyl group, a sulfone group, an imino group, or a thiol group, i represents a natural number, n represents an integer of two or more and four or less, and * represents a bonding position with another atom constituting the graft chain; and Ai may be identical or different from each other.

Abstract: A drive circuit drives a switch configuring a power converter. The drive circuit divides an inter-terminal voltage of a switch. The drive circuit includes a differential circuit having first and second input terminals to which the divided inter-terminal voltages are inputted. The differential circuit outputs an analog voltage based on a voltage difference between the input terminals. The differential circuit executes reset of the output voltage, and with the voltage difference when reset is canceled after reset is executed as a reference voltage, outputs an analog voltage in which an amount of change from the reference voltage is multiplied by an amplification factor. The drive circuit outputs a binary signal based on comparison results between a threshold and the analog voltage outputted from the differential circuit, and sets a transfer rate of a gate charge of the switch when a driving state is switched, based on the output signal thereof.

Abstract: A signal detection circuit detects, as a detection target signal, a signal of a main terminal of a switching element by comparing the detection target signal with a reference signal. The signal detection circuit includes: a signal generation unit generating the reference signal; a first capacitor having a first terminal connected with the main terminal of the switching element; a second capacitor having a first terminal connected with an output terminal of the signal generation unit; and a detection circuit receiving, as input signals, a signal output from a second terminal of the first capacitor and a signal output from a second terminal of the second capacitor, and the detection circuit detecting the detection target signal based on the input signals.

Abstract: A signal detection circuit includes: a first capacitor having a first terminal connected with a first main terminal of a switching element; a second capacitor having a first terminal connected with a second main terminal of the switching element; and a detection circuit having a differential circuit configuration. The detection circuit receives, as input signals, a signal from a second terminal of the first capacitor and a signal from a second terminal of the second capacitor, detects detection target signals based on the input signals. The detection target signals include a signal of the first main terminal of the switching element and a signal of the second main terminal of the switching element.

Abstract: Provided is an external skin preparation capable of enhancing permeability of an active ingredient into parts of the epidermis located below the stratum corneum and the dermis even when a poorly water-soluble active ingredient is used. There is provided an external skin preparation containing a core-shell structure, comprising a core portion containing a poorly water-soluble active ingredient and a solubilizing agent, and a shell portion containing a surfactant. The solubilizing agent is at least one selected from the group consisting of cyclodextrin, methyl-cyclodextrin, dimethyl-cyclodextrin, 2-hydroxypropyl-cyclodextrin, hydroxyethyl-cyclodextrin, sulfobutyl ether-cyclodextrin, glucosyl-cyclodextrin, maltosyl-cyclodextrin and cluster dextrin. The surfactant is at least one selected from the group consisting of glycerol fatty acid esters, sorbitan fatty acid esters, propylene glycol fatty acid esters and fatty acid alkanolamides.

Abstract: Provided is a core-shell structure having an excellent immediate effect in transdermal absorption of an active ingredient. A core-shell structure comprising a core portion containing an active ingredient, and a shell portion containing a surfactant having an HLB value of 4 to 14, the core portion being solid, and the surfactant containing a saturated hydrocarbon group having 7 to 15 carbon atoms or an unsaturated hydrocarbon group having 7 to 17 carbon atoms.

Abstract: Provided is an external skin preparation capable of enhancing permeability of an active ingredient into parts of the epidermis located below the stratum corneum and the dermis even when a poorly water-soluble active ingredient is used. There is provided an external skin preparation comprising a poorly water-soluble active ingredient and a solubilizing agent, wherein the solubilizing agent is at least one selected from the group consisting of water-soluble polymers, water-soluble saccharides, water-soluble surfactants and aromatic carboxylic acids.

Abstract: Provided is a core-shell structure having an excellent immediate effect in transdermal absorption of an active ingredient. A core-shell structure comprising a core portion containing an active ingredient, and a shell portion containing a surfactant having an HLB value of 4 to 14, the core portion being solid, and the surfactant containing a saturated hydrocarbon group having 7 to 15 carbon atoms or an unsaturated hydrocarbon group having 7 to 17 carbon atoms.

Abstract: The present invention is to reduce the flow rate of pressure oil discharged from a main pump and returned to a tank when specific work is executed with an operation amount of an operating device being made small in the state in which an engine is kept at an idling speed. According to the present invention, there is provided a main controller (20) which is capable of controlling the speed of an engine (11) to a normal work speed at which a work implement such as a boom (4) can perform normal work and which controls the speed of the engine (11) to an idling speed serving as a speed lower than the normal work speed when an operating device has returned from an operating position to a neutral position.

Abstract: The present invention is to reduce the flow rate of pressure oil discharged from a main pump and returned to a tank when specific work is executed with an operation amount of an operating device being made small in the state in which an engine is kept at an idling speed. According to the present invention, there is provided a main controller (20) which is capable of controlling the speed of an engine (11) to a normal work speed at which a work implement such as a boom (4) can perform normal work and which controls the speed of the engine (11) to an idling speed serving as a speed lower than the normal work speed when an operating device has returned from an operating position to a neutral position.