Patents by Inventor Yuval Eitan

Yuval Eitan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Natural tissue-derived decellularized matrix and methods of generating and using same
    Patent number: 9216236
    Abstract: Decellularized tissue-derived extracellular matrices (ECM) and methods of generating and using same are provided. The method of generating a decellularized matrix includes the steps of: (a) subjecting the tissue to washes and a hypertonic buffer; (b) subjecting the tissue to an enzymatic proteolytic digestion with an enzyme such as trypsin; and (c) removing all cellular components from the tissue using a detergent solution which includes Triton-X-100 and ammonium hydroxide. Specifically, there is provided a decellularized myocardium-derived matrix which is completely devoid of all cellular components and hence non-immunogenic in a subject, exhibits suitable structural and mechanical properties for cardiac tissue engineering or replacement therapy of damaged cardiac tissue, and is capable of remodeling upon seeding of cells.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: December 22, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Marcelle Machluf, Yuval Eitan
  • Natural Tissue-Derived Decellularized Matrix and Methods of Generating and Using Same
    Publication number: 20150050247
    Abstract: Decellularized tissue-derived extracellular matrices (ECM) and methods of generating and using same are provided. The method of generating a decellularized matrix includes the steps of: (a) subjecting the tissue to washes and a hypertonic buffer; (b) subjecting the tissue to an enzymatic proteolytic digestion with an enzyme such as trypsin; and (c) removing all cellular components from the tissue using a detergent solution which includes Triton-X-100 and ammonium hydroxide. Specifically, there is provided a decellularized myocardium-derived matrix which is completely devoid of all cellular components and hence non-immunogenic in a subject, exhibits suitable structural and mechanical properties for cardiac tissue engineering or replacement therapy of damaged cardiac tissue, and is capable of remodeling upon seeding of cells.
    Type: Application
    Filed: March 7, 2006
    Publication date: February 19, 2015
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Marcelle Machluf, Yuval Eitan
  • Abundant, well distributed and hyperpolymorphic simple sequence repeats in prokaryote genomes and use of same for prokaryote classification and typing
    Publication number: 20030044804
    Abstract: A method is provided for classifying or typing a prokaryote to a class or a type. The method is effected by characterizing at least one polymorphic simple sequence repeat locus in a genome of the prokaryote and, based on a characterization of the polymorphic simple sequence repeat, classifying or typing the prokaryote to a class or a type. Compounds and articles of manufacture are provided for effecting the method.
    Type: Application
    Filed: October 9, 2001
    Publication date: March 6, 2003
    Inventors: Yechezkel Kashi, Riva Gur-Arie, Cyril Cohen, Yuval Eitan, Leora Shelef, Eric Hallerman
  • Abundant, well distributed and hyperpolymorphic simple sequence repeats in prokaryote genomes and use of same for prokaryote classification and typing
    Patent number: 6322985
    Abstract: A method is provided for classifying or typing a prokaryote to a class or a type. The method is effected by characterizing at least one polymorphic simple sequence repeat locus in a genome of the prokaryote and, based on a characterization of the polymorphic simple sequence repeat, classifying or typing the prokaryote to a class or a type. Compounds and articles of manufacture are provided for effecting the method.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: November 27, 2001
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Yechezkel Kashi, Riva Gur-Arie, Cyril Cohen, Yuval Eitan, Leora Shelef, Eric Hallerman