Abstract: In general, the invention features an intra-vascular device for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels. the device of the invention may include a filter to prevent a particle in a blood vessel from passing through the filter, a lateral structure to hold the filter, and two wires attached to lateral structure, on each at its distal and proximal ends. These wires may be used to control the deflection or orientation of the filter upon its installation within a blood vessel. Further, in some embodiments, these wires may be capable of readily detaching from the device, thus making it possible to install a filter without any significant appendages in a blood vessel.

Abstract: A non-occlusive device is provided that includes a coilable section and a docking section. The coilable section is configured to become coiled into a coil when deployed from a microcatheter within a vascular malformation. The coil is shaped so as to define a sequence of concentric loops. The coil is configured to bridge a neck of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, when in use. The docking section is configured to be deployed from the microcatheter within the vascular malformation. The docking section is configured to, when in use, perform one or more functions selected from the group consisting of: anchoring the device within the vascular malformation, stabilizing the device within the vascular malformation, assisting with positioning of the device within the vascular malformation, and intertwining detachable coils delivered to the vascular malformation. Other embodiments are also described.

Abstract: Apparatus (720) is provided for treating a vascular malformation, including an orifice section (430), an occlusion section (432), and a connecting section (434). When the apparatus (720) is uncontrained, the orifice and occlusion sections (430, 432) are shaped so as to define orifice-section and occlusion-section curves (440, 450) that wind around non-coaxial orifice-section and occlusion-section central axes (442, 452), respectively, at changing distances from the axes (442, 452). The orifice-section curve (440) defines an orifice-section central opening (462). A projection of the occlusion-section curve (450) occludes at least 25% of a orifice-section-central-opening cross-sectional area of an orifice-section central opening (462); the projection of the occlusion-section curve (450) is in a direction along the orifice-section central axis (442), onto an orifice-section plane perpendicular to the orifice-section central axis (442). Other embodiments are also described.

Abstract: A delivery tool (22) includes a tubular distal tip (52) fixed to a distal end (54) of a delivery tube (50). A retention portion (38) of an implant wire (30) of an implant (20) is removably disposed within the tubular distal tip (52). A safety wire (60) is removably disposed partially within the tubular distal tip (52), with a distal portion (62) of the safety wire (60) passing through a tip distal opening (56). The safety wire (60) is shaped so as to define a helical portion (90), which, when unconstrained, has an unconstrained helical-portion outer diameter that is greater than a greatest inner diameter of the tubular distal tip (52). Proximal pulling on the safety wire (60) proximally retracts the safety wire (60) from the tip distal opening (56), thereby allowing the retention portion (38) to pass through the tubular distal tip (52). Other embodiments are also described.

Abstract: A non-occlusive device is provided that includes a coilable section and a docking section. The coilable section is configured to become coiled into a coil when deployed from a microcatheter within a vascular malformation. The coil is shaped so as to define a sequence of concentric loops. The coil is configured to bridge a neck of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, when in use. The docking section is configured to be deployed from the microcatheter within the vascular malformation. The docking section is configured to, when in use, perform one or more functions selected from the group consisting of: anchoring the device within the vascular malformation, stabilizing the device within the vascular malformation, assisting with positioning of the device within the vascular malformation, and intertwining detachable coils delivered to the vascular malformation. Other embodiments are also described.

Abstract: A non-occlusive device is provided that includes a coilable section and a docking section. The coilable section is configured to become coiled into a coil when deployed from a microcatheter within a vascular malformation. The coil is shaped so as to define a sequence of concentric loops. The coil is configured to bridge a neck of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, when in use. The docking section is configured to be deployed from the microcatheter within the vascular malformation. The docking section is configured to, when in use, perform one or more functions selected from the group consisting of: anchoring the device within the vascular malformation, stabilizing the device within the vascular malformation, assisting with positioning of the device within the vascular malformation, and intertwining detachable coils delivered to the vascular malformation. Other embodiments are also described.

Abstract: This invention relates to devices that are inserted in a blood vessel or other body lumen, and in particular to filter that may block particles from entering a blood vessel. Devices of this invention position and secure a filter in a vascular system to intercept particulates, including emboli.

Abstract: In general, the invention features an intra-vascular device for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels. The device of the invention may include a filter, an central member, additional supporting members, and a delivery cable and may serve to filter or deflect emboli or other large objects from entering protected secondary vessels. The device may be capable of collapse along its longitudinal axis for ease of delivery to the treatment site. The device may further be compatible with common delivery methods used in interventional cardiology (e.g., TAVI procedures). The device may be integrated into the delivery systems. In other embodiments the device may be detachable from the delivery system. Upon deployment, the device may be positioned so as to contact the orifice of one or more secondary blood vessels. Upon retrieval the device may be retracted in an orientation substantially similar to the original deployment orientation.

Abstract: This invention relates to devices that are inserted in a blood vessel or other body lumen, and in particular to filter that may block particles from entering a blood vessel. Devices of this invention position and secure a filter in a vascular system to intercept particulates, including emboli.

Abstract: A non-occlusive device is provided that includes a coilable section and a docking section. The coilable section is configured to become coiled into a coil when deployed from a microcatheter within a vascular malformation. The coil is shaped so as to define a sequence of concentric loops. The coil is configured to bridge a neck of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, when in use. The docking section is configured to be deployed from the microcatheter within the vascular malformation. The docking section is configured to, when in use, perform one or more functions selected from the group consisting of: anchoring the device within the vascular malformation, stabilizing the device within the vascular malformation, assisting with positioning of the device within the vascular malformation, and intertwining detachable coils delivered to the vascular malformation. Other embodiments are also described.

Abstract: In general, the invention features an intra-vascular device (100) for filtering or deflecting emboli other large objects from entering a protected secondary vessel or vessels. The device of the invention may include a filter (201) to prevent a particle in a blood vessel from passing through the filter, a lateral structure (200) to hold the filter, and two wires (202, 203) attached the lateral structure, one each at its distal and proximal ends (206a, 206b). These wires may be used to control the deflection or orientation of the filter upon its installation within a blood vessel. Further, in some embodiments, these wires may be capable of readily detaching from the device, thus making it possible to install a filter without any significant appendages in a blood vessel.

Abstract: This invention relates to devices that are inserted in a blood vessel or other body lumen, and in particular to filter that may block particles from entering a blood vessel. Devices of this invention position and secure a filter in a vascular system to intercept particulates, including emboli.

Abstract: The invention features intravascular devices, in particular devices for deflecting emboli (100), and elements for connecting such devices to wires. Such connecting elements are configured to limit within a range the relative rotation between device and wire.

Abstract: The device of the invention may include an interlaced portion (1) and internal inserts (17) that exit the interlaced portion, form a loop, e.g., an external member, and optionally re-enter the interlaced portion. The interlace portion may filter and/or deflect emboli or other large objects from entering protected secondary vessels, while the external member may facilitate device placement within the primary vessel. The device may further be compatible with common delivery methods used in interventional cardiology (e.g., TAVI procedures). The device may be integrated into a delivery system. In other embodiments, the device may be detachable from the delivery system. Upon deployment, the device may be positioned so as to contact the orifice of one or more secondary blood vessels to, e.g., the aortic arch. In still other embodiments, the filaments may be arranged so that the edge of the device is relatively flexible and may serve as a gasket for improved device performance within a primary vessel.

Abstract: Methods and apparatus for connecting to a bone, which avoid the use of bone screws. A triangular shaped modular implant is used, with two sides of the structure and their respective vertex secured generally within the bone, with the base of the triangle outside the bone. These two arms, whether straight or arcuate, are cannulated, and are held together at their distal ends by a tightened cable that runs through both of the arms. The proximal ends of these arms are connected to a base side that completes the triangular structure. The device may be inserted into a vertebra and the base used for vertebral fusion. Alternatively, the arms themselves may be used to stabilize and fixate adjacent vertebrae, by insertion through adjacent vertebrae trans-segmentally. In the latter case, the vertex may be within the intervertebral space or within the vertebral body close to the intervertebral space.

Abstract: The invention features an intra-vascular device (10) which may include a filter (30), a filter insert (36), and a supporting structure (40) to hold a filtering element and may serve to filter or deflect emboli or other large objects from entering protected secondary vessels. The device may be capable of collapse along its longitudinal axis (80) for ease of delivery to the treatment site. The device may further be compatible with common delivery methods (e.g., TAVI procedures). Upon deployment, the device may be positioned in a middle area of a blood vessel (e.g., an aortic arch) near but not in contact with one or more second blood vessels (e.g., the branch arteries of the aorta). The supporting structure may be capable of pressing against the medial wall of a blood vessel (e.g., the aorta) and provide lift to the device so that a middle portion of the device is above a lateral plane of the device.

Abstract: In general, the invention features an intra-vascular device for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels. The device of the invention may include a filter, an central member, additional supporting members, and a delivery cable and may serve to filter or deflect emboli or other large objects from entering protected secondary vessels. The device may be capable of collapse along its longitudinal axis for ease of delivery to the treatment site. The device may further be compatible with common delivery methods used in interventional cardiology (e.g., TAVI procedures). The device may be integrated into the delivery systems. In other embodiments the device may be detachable from the delivery system. Upon deployment, the device may be positioned so as to contact the orifice of one or more secondary blood vessels. Upon retrieval the device may be retracted in an orientation substantially similar to the original deployment orientation.

Abstract: An intra-vascular device (100) may include a skeleton (102) to hold a blood filter (104), an upper member (110) to fit into a branch artery of an aorta, and a pair of lower members (106, 108) whose distal ends are not connected to each other, such lower members to press against a wall of an ascending artery and to provide lift to the device so that a middle portion of the device is above a lateral plane of the device. The device may be positioned in a middle area of an aortic arch near but not covering an opening of the branch arteries of the aorta, and may filter or deflect emboli or other large objects from entering into the branch arteries.

Abstract: Methods of application and devices thereof for tissue adhesives. The adhesives comprise a plurality of components which are provided separately but which are mixed together to form the adhesive. At least one component is a crosslinkable protein solution and at least one other component is a crosslinking material solution. The devices preferably include a mixing unit, which may include dynamic mixing elements, static mixing elements, or a combination of the two.

Abstract: A device implantable into a blood vessel having a filter to prevent particles from passing into a blood vessel, and having bows extending from a horizontal plain of the device, such bows to hold such device in place in a blood vessel.