Abstract: Mutant M-CSF protein, comprising ?v?3 integrin binding motif and pharmaceutical compositions comprising same, are provided. Further, use of the composition for the treatment and or prevention of diseases associated with increased bone resorption are provided.

Abstract: Systems and methods provide accelerated MR thermometry utilizing prior knowledge about the images to be reconstructed from incomplete k-space data, thereby facilitating accurate reconstruction. In various embodiments, missing data is computationally estimated using a machine learning algorithm such as a neural network, and an image is generated based on iteratively updated estimated missing information.

Abstract: Systems and methods provide accelerated MR thermometry utilizing prior knowledge about the images to be reconstructed from incomplete k-space data, thereby facilitating accurate reconstruction. In various embodiments, missing data is computationally estimated using a machine learning algorithm such as a neural network, and an image is generated based on iteratively updated estimated missing information.

Abstract: Mutant M-CSF protein, comprising ?v?3 integrin binding motif and pharmaceutical compositions comprising same, are provided. Further, use of the composition for the treatment and or prevention of diseases associated with increased bone resorption are provided.

Abstract: Mutant M-CSF protein, comprising ?v?3 integrin binding motif and pharmaceutical compositions comprising same, are provided. Further, use of the composition for the treatment and or prevention of diseases associated with increased bone resorption are provided.

Abstract: A 3D parallel imaging method includes the steps of acquiring a partial CPMG data set, acquiring a partial CP data set, and interleaving the partial CPMG data set and the partial CP data set at different ky-kz locations.

Abstract: A system and method for MR imaging is disclosed. The method causes an RF coil assembly and plurality of gradient coils to apply a fast spin echo (FSE) pulse sequence comprising a preparation segment and a plurality of refocusing segments. The FSE pulse sequence generates a pair of echoes is generated in each of the plurality of refocusing segments that comprises a first echo generated by magnetization pathways having an even number of phase inversions and a second echo generated by magnetization pathways having an even number of phase inversions. MR signals are acquired from the first echo and the second echo and an image of at least a portion of a subject of interest is reconstructed from the acquired MR signals.

Abstract: A system and method for MR imaging is disclosed. The method causes an RF coil assembly and plurality of gradient coils to apply a fast spin echo (FSE) pulse sequence comprising a preparation segment and a plurality of refocusing segments. The FSE pulse sequence generates a pair of echoes is generated in each of the plurality of refocusing segments that comprises a first echo generated by magnetization pathways having an even number of phase inversions and a second echo generated by magnetization pathways having an even number of phase inversions. MR signals are acquired from the first echo and the second echo and an image of at least a portion of a subject of interest is reconstructed from the acquired MR signals.

Abstract: A system and method for focusing ultrasound into a target tissue is disclosed. The method calculates a pressure field for an array of transducer elements to generate an unaberrated pressure field matrix and causes the transducer elements to apply focused ultrasound to generate a respective aberrated pressure field at a focus location in a target tissue and surrounding volume. MR-ARFI images are acquired of the focus location and surrounding volume, a magnitude of the aberrated pressure field is measured that is generated by the applied focused ultrasound at respective focus locations in the target tissue and surrounding volume based on the MR-ARFI images, an aberration for the transducer elements is determined from the pressure field matrix and the MR-ARFI images of the focus location and the surrounding volume using a magnitude least-squares method, and a corrective phase/amplitude adjustment is applied to the transducer elements based on the determined aberrations.

Abstract: A system and method for focusing ultrasound into a target tissue is disclosed. The method calculates a pressure field for an array of transducer elements to generate an unaberrated pressure field matrix and causes the transducer elements to apply focused ultrasound to generate a respective aberrated pressure field at a focus location in a target tissue and surrounding volume. MR-ARFI images are acquired of the focus location and surrounding volume, a magnitude of the aberrated pressure field is measured that is generated by the applied focused ultrasound at respective focus locations in the target tissue and surrounding volume based on the MR-ARFI images, an aberration for the transducer elements is determined from the pressure field matrix and the MR-ARFI images of the focus location and the surrounding volume using a magnitude least-squares method, and a corrective phase/amplitude adjustment is applied to the transducer elements based on the determined aberrations.

Abstract: Phase and magnitude correction is performed in two dimensions to reduce ghosting in single shot and multi-shot EPI scans. First, a phase/magnitude correction in the readout direction is carried out to reduce echo shifts and gradient waveform distortions. Then, a two dimensional phase/magnitude correction is performed to remove the remaining xy phase/magnitude errors.

Abstract: A system and method for MR based tracking of a tissue point includes a RF coil assembly configured to emit RF pulse sequences and a system control coupled to the RF coil assembly. The system control is programmed to cause the RF coil assembly to emit a first RF pulse comprising a first pair of two-dimensional (2D) spatially selective beams, each of the beams being directed to a respective tagging location in the subject of interest and wherein the tagging locations are equidistant from a pre-determined point-of-interest. The system control is further programmed to acquire a first series of MR images from a subject of interest, identify the first pair of 2D spatially selective beams in each MR image in the first series of MR images, and track a position of the point-of-interest based on the identified 2D spatially selective beams in the first series of MR images.

Abstract: A system and method for MR based tracking of a tissue point includes a RF coil assembly configured to emit RF pulse sequences and a system control coupled to the RF coil assembly. The system control is programmed to cause the RF coil assembly to emit a first RF pulse comprising a first pair of two-dimensional (2D) spatially selective beams, each of the beams being directed to a respective tagging location in the subject of interest and wherein the tagging locations are equidistant from a pre-determined point-of-interest. The system control is further programmed to acquire a first series of MR images from a subject of interest, identify the first pair of 2D spatially selective beams in each MR image in the first series of MR images, and track a position of the point-of-interest based on the identified 2D spatially selective beams in the first series of MR images.

Abstract: Phase and magnitude correction is performed in two dimensions to reduce ghosting in single shot and multi-shot EPI scans. First, a phase/magnitude correction in the readout direction is carried out to reduce echo shifts and gradient waveform distortions. Then, a two dimensional phase/magnitude correction is performed to remove the remaining xy phase/magnitude errors.

Abstract: Phase and magnitude correction is performed in two dimensions to reduce ghosting in single shot and multi-shot EPI scans. First, a phase/magnitude correction in the readout direction is carried out to reduce echo shifts and gradient waveform distortions. Then, a two dimensional phase/magnitude correction is performed to remove the remaining xy phase/magnitude errors.

Abstract: Phase and magnitude correction is performed in two dimensions to reduce ghosting in single shot and multi-shot EPI scans. First, a phase/magnitude correction in the readout direction is carried out to reduce echo shifts and gradient waveform distortions. Then, a two dimensional phase/magnitude correction is performed to remove the remaining xy phase/magnitude errors.

Abstract: Artifacts in MR images caused by signals emanating from outside the design spherical volume (DSV) of the system are suppressed using customized spatial saturation pulse sequences interleaved with imaging pulse sequences. The spatial saturation pulse sequences are each customized to a specific region and are stored in a library for selective use when needed to suppress artifact producing signals emanating from specific regions outside the DSV.

Abstract: A probe, with a longitudinal axis, for use in an NMR system, the probe comprising: (a) a plurality of static magnetic field sources which create a static magnetic field that is non-axisymmetric about the longitudinal axis, in a region outside the probe; and (b) at least one antenna, compromising one or more antennas together capable of creating a time-varying magnetic field which is capable of exciting nuclei in a sub-region of the region, and capable of receiving NMR signals from said excited nuclei and generating NMR electrical signals therefrom; wherein the plurality of magnetic field sources comprise adjacent static magnetic field sources that are magnetized in directions that differ by more than 10 degrees and less than 170 degrees.

Abstract: An imaging probe for imaging inside a cavity surrounded by a wall, the probe comprising: a) a probe body having a contracted state and an expanded state; and b) at least two imaging sensors, mounted on the probe body and having fields of view in different directions; wherein, when the probe body is in the expanded state, the fields of view of the imaging sensors respectively comprise portions of the wall of the cavity on different sides of the cavity.

Abstract: A method for performing MRI, including imposing N sets of steady-state free precession (SSFP) sequences on an object to be imaged, the sequences including respective initial radio-frequency (RF) excitation pulses, each initial RF excitation pulse having a predetermined phase shift relative to the other initial RF excitation pulses. N is a whole number larger than one and less than six. The method further includes setting the phase shift of the RF pulse of the sequences so that the phase shift of the RF pulse of an Mth sequence is substantially equal to 2 ⁢ π ⁡ ( M - 1 ) N radians, wherein M is a whole number larger than 0 and less than or equal to N, receiving a respective set of image signals from the object responsive to the N sets of SSFP sequences, and processing the set of received image signals to generate an image of the object.