Patents by Inventor Yuxin QI
Yuxin QI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11960675Abstract: The application provides a display apparatus. The display apparatus includes: a touch panel, configured to receive a touch operation and comprising a touch film and a display panel configured to display an image; a backlight module configured to provide a backlight source to the touch panel and including a backplane, a reflective sheet, a light guide plate, an optical film and a light source located on one side of the backplane; a touch pad, configured to drive and control the touch film; and a plurality of flexible circuit boards, through which the touch film is electrically connected with the touch pad, and which are located on a same side of the touch film.Type: GrantFiled: October 12, 2022Date of Patent: April 16, 2024Assignee: Hisense Visual Technology Co., Ltd.Inventors: Dongxin Qi, Aichen Xu, Ying Chen, Caixia Zhao, Yuxin Zhang
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Publication number: 20230064377Abstract: A preparation method of a high-optical-purity chiral oxo-aza-cycloalkane compound comprises the steps of: (R or S)N-substituent P-2-alkoxycarbonylalkyliminodiacetic acid diester as the raw material is cyclized in the presence of a solvent and a cyclization reagent (lewis acid-lewis base) to obtain high-optical-purity N-substituent P -2- (R or S)- substituent G oxo-aza-cycloalkane or the salt thereof through thermal decarboxylation or hydrolysis decarboxylation reaction; the specific type of cyclization reagent used in the present invention is conductive to the preparation of the high-optical-purity target product, easily recoverable, with reduced waste liquid discharge, green, and environment-friendly, which contributes to green industrial production.Type: ApplicationFiled: October 20, 2020Publication date: March 2, 2023Inventors: Xianlong JIANG, Mingfeng ZHANG, Yuxin QI
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Publication number: 20220112168Abstract: N-substituted formyl-alpha-substituted glycine ester is used as the initial raw material, a cyclization reaction is performed under the action of a dehydrating agent (trisubstituted phosphine dihalide, a combination of trisubstituted phosphine dihalide and an acyl halide reagent, or a combination of trisubstituted phosphine oxide and an acyl halide reagent) and an organic amine to obtain the substituted oxazole compound, and the resulting substituted oxazole compound can be further saponified and de-carboxylated to obtain a medical intermediate 4-substituent-5-substituent oxy-oxazole; the reaction process can be carried out in a continuous flow mode to improve the productivity and reduce operations; the byproduct trisubstituted phosphine oxide in the reaction process can be repeatedly used to reduce the cost; dehydrating agents (phosphorus oxychloride and phosphorus pentoxide).Type: ApplicationFiled: December 8, 2021Publication date: April 14, 2022Inventors: Xinfa LI, Lishan ZHOU, Chengwei WANG, Ningning LIU, Yuxin QI
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Patent number: 11208417Abstract: The present invention provides a simple process of preparing avibactam. Piperidine-5-one-2S-carboxylate II as the raw material is subjected to condensation reaction with O-protecting hydroxylamine hydrochloride; the resulting compound is subjected to reduction and chiral resolution to obtain 5R-substituted oxyaminopiperidine-2S-carboxylic acid V in a basic condition; then, the compound of formula V is subjected to urea cyclization, acyl chlorination, and amidation with phosgene, solid phosgene, or diphosgene in a “one-pot” process, and then subjected to deprotection, sulfation, and tetrabutylammonium salt formation reaction to obtain (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl]oxy}sulfonyl tetra-n-butyl ammonium salt VII, and finally, the compound of formula VII is subjected to ion exchange to obtain avibactam I.Type: GrantFiled: March 6, 2018Date of Patent: December 28, 2021Assignee: XINFA PHARMACEUTICAL CO., LTDInventors: Yuxin Qi, Baolin Wang, Xin Xu, Lizhu Ju, Xinfa Li
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Publication number: 20210355143Abstract: A simple method is preparing Vaborbactam, in which S-3-hydroxy-6-oxohexanoic acid ester is used as the starting material to finally form the Vaborbactam (I) by carrying out the procedures of hydroxyl protection, imidization, asymmetric addition from borane or borate compounds, amino deprotection, amidation, cyclization and hydrolysis. The present invention is suitable for commercial production by virtue of the advantages: widely available and low cost raw materials; safe, simple and convenient process steps; no rigorous reaction conditions; and environment-friendly reaction courses.Type: ApplicationFiled: September 29, 2019Publication date: November 18, 2021Inventors: Yuxin QI, Xin XU, Yuesheng LIU
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Publication number: 20210332060Abstract: The present invention provides a simple process of preparing avibactam. Piperidine-5-one-2S-carboxylate II as the raw material is subjected to condensation reaction with O-protecting hydroxylamine hydrochloride; the resulting compound is subjected to reduction and chiral resolution to obtain 5R-substituted oxyaminopiperidine-2S-carboxylic acid V in a basic condition; then, the compound of formula V is subjected to urea cyclization, acyl chlorination, and amidation with phosgene, solid phosgene, or diphosgene in a “one-pot” process, and then subjected to deprotection, sulfation, and tetrabutylammonium salt formation reaction to obtain (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl]oxy}sulfonyl tetra-n-butyl ammonium salt VII, and finally, the compound of formula VII is subjected to ion exchange to obtain avibactam I.Type: ApplicationFiled: March 6, 2018Publication date: October 28, 2021Inventors: Yuxin QI, Baolin WANG, Xin XU, Lizhu JU, Xinfa LI
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Publication number: 20210323920Abstract: The present application relates to methods of preparing 5R-[(benzyloxy) amino] piperidine-2S-carboxylic acid or its derivatives in an environment-friendly way. The method uses L-glutamic acid as a starting material, which is first subjected to esterification reaction in the presence of an acidic reagent, and then reacted successively with 2-haloacetate and N-protecting agent, or with N-protecting agent and 2-haloacetate under a basic condition to obtain compound IV; then, the obtained compound IV is subjected to intramolecular condensation into a ring under the action of a strong base to obtain N-protecting group piperidine-5-one-2S-carboxylate (V).Type: ApplicationFiled: March 6, 2018Publication date: October 21, 2021Inventors: Yuxin QI, Xinfa LI, Xin XU, Baolin WANG, Hu QU, Shungen XIE
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Patent number: 11142499Abstract: The present application relates to methods of preparing 5R-[(benzyloxy) amino] piperidine-2S-carboxylic acid or its derivatives in an environment-friendly way. The method uses L-glutamic acid as a starting material, which is first subjected to esterification reaction in the presence of an acidic reagent, and then reacted successively with 2-haloacetate and N-protecting agent, or with N-protecting agent and 2-haloacetate under a basic condition to obtain compound IV; then, the obtained compound IV is subjected to intramolecular condensation into a ring under the action of a strong base to obtain N-protecting group piperidine-5-one-2S-carboxylate (V).Type: GrantFiled: March 6, 2018Date of Patent: October 12, 2021Assignee: XINFA PHARMACEUTICAL CO., LTDInventors: Yuxin Qi, Xinfa Li, Xin Xu, Baolin Wang, Hu Qu, Shungen Xie
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Patent number: 10662190Abstract: It relates to improved processes of preparing 5R-[(benzyloxy) amino] piperidine-2S-carboxylate and oxalate thereof. In the present invention, L-glutamic acid or L-glutamic acid sodium salt as the starting material is reacted with chloroactic acid under an alkaline condition via a substitution reaction to obtain compound III; then, compound III is reacted with alcohol in the presence of acid reagent via esterification reaction to obtain compound IV; under the action of strong base, compound IV is subjected to intramolecular condensation into ring, hydrolysis-decarboxylation, and esterification to obtain compound V; compound V is condensed with benzyloxy amine hydrochloride salt in the presence of alkaline to obtain compound VI; compound VI is subjected to reduction and chiral resolution to obtain 5R-[(benzyloxy) amino] piperidine-2S-carboxylate oxalate (IIb) which is then neutralized to obtain 5R-[(benzyloxy) amino] piperidine-2S-carboxylate (IIa).Type: GrantFiled: March 2, 2018Date of Patent: May 26, 2020Assignee: XINFA PHARMACEUTICAL CO., LTDInventors: Baolin Wang, Yuxin Qi, Yinlong Zhao, Yuqi Teng, Jun Chen, Lizhu Ju, Xinfa Li
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Patent number: 10570133Abstract: A compound of Formula III as the raw material is hydrolyzed in an alkaline condition, then acidized to prepare a compound of Formula IV, and the resulting compound of formula IV and a solid phosgene or diphosgene are concurrently subjected to the urea cyclization and the chloroformylation reaction in the presence of an organic base and a catalyst to obtain a compound of formula V, and then the compound of formula V is amidated to obtain the final product (II). In the present invention, a “one-pot” method is adopted for urea cyclization, chloroformylation, and amidation reaction, and the intermediate products do not need post-treatments such as separation and purification.Type: GrantFiled: March 23, 2018Date of Patent: February 25, 2020Assignee: XINFA PHARMACEUTICAL CO., LTDInventors: Yuxin Qi, Xinfa Li, Baolin Wang, Xin Xu, Yinlong Zhao, Yuqi Teng
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Patent number: 10570132Abstract: A method for preparing an intermediate for avibactam, and specifically relates to a method for preparing ({[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt (II). With 5R-[(benzyloxy) amino] piperidine-2S-carboxylate oxalate (III) as the raw material is reacted with the amide of Formula IV via amidation to prepare the compound of Formula V; the resulting compound of Formula V is reacted with the carbonylation reagent via urea cyclization to obtain the compound of Formula VI; the benzyl or the substituted benzyl in the compound of Formula VI is removed by catalytic hydrogeneration, then the resulting compound is sulfatated by sulfur trioxide complex and is salinized into tetrabutylammonium to obtain the final product (II).Type: GrantFiled: March 6, 2018Date of Patent: February 25, 2020Assignee: XINFA PHARMACEUTICAL CO., LTDInventors: Yuxin Qi, Xinfa Li, Baolin Wang, Hu Qu, Xin Xu, Lizhu Ju
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Publication number: 20190263813Abstract: A compound of Formula III as the raw material is hydrolyzed in an alkaline condition, then acidized to prepare a compound of Formula IV, and the resulting compound of formula IV and a solid phosgene or diphosgene are concurrently subjected to the urea cyclization and the chloroformylation reaction in the presence of an organic base and a catalyst to obtain a compound of formula V, and then the compound of formula V is amidated to obtain the final product (II). In the present invention, a “one-pot” method is adopted for urea cyclization, chloroformylation, and amidation reaction, and the intermediate products do not need post-treatments such as separation and purification.Type: ApplicationFiled: March 23, 2018Publication date: August 29, 2019Inventors: Yuxin QI, Xinfa LI, Baolin WANG, Xin XU, Yinlong ZHAO, Yuqi TENG
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Publication number: 20190263812Abstract: A method for preparing an intermediate for avibactam, and specifically relates to a method for preparing ({[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt (II). With 5R-[(benzyloxy) amino] piperidine-2S-carboxylate oxalate (III) as the raw material is reacted with the amide of Formula IV via amidation to prepare the compound of Formula V; the resulting compound of Formula V is reacted with the carbonylation reagent via urea cyclization to obtain the compound of Formula VI; the benzyl or the substituted benzyl in the compound of Formula VI is removed by catalytic hydrogeneration, then the resulting compound is sulfatated by sulfur trioxide complex and is salinized into tetrabutylammonium to obtain the final product (II).Type: ApplicationFiled: March 6, 2018Publication date: August 29, 2019Inventors: Yuxin QI, Xinfa LI, Baolin WANG, Hu QU, Xin XU, Lizhu JU
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Publication number: 20190256514Abstract: It relates to improved processes of preparing 5R-[(benzyloxy) amino] piperidine-2S-carboxylate and oxalate thereof. In the present invention, L-glutamic acid or L-glutamic acid sodium salt as the starting material is reacted with chloroactic acid under an alkaline condition via a substitution reaction to obtain compound III; then, compound III is reacted with alcohol in the presence of acid reagent via esterification reaction to obtain compound IV; under the action of strong base, compound IV is subjected to intramolecular condensation into ring, hydrolysis-decarboxylation, and esterification to obtain compound V; compound V is condensed with benzyloxy amine hydrochloride salt in the presence of alkaline to obtain compound VI; compound VI is subjected to reduction and chiral resolution to obtain 5R-[(benzyloxy) amino] piperidine-2S-carboxylate oxalate (IIb) which is then neutralized to obtain 5R-[(benzyloxy) amino] piperidine-2S-carboxylate (IIa).Type: ApplicationFiled: March 2, 2018Publication date: August 22, 2019Inventors: Baolin WANG, Yuxin QI, Yinlong ZHAO, Yuqi TENG, Jun CHEN, Lizhu JU, Xinfa LI