Patents by Inventor Yuxuan DAI

Yuxuan DAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ZIKA/DENGUE VACCINE AND APPLICATION THEREOF
    Publication number: 20240173395
    Abstract: Provided in the present disclosure are a Zika/dengue vaccine and its application thereof. The present disclosure introduces a mutation into the E-protein FL fusion region of the Zika virus or dengue virus. Antigens with said mutations are unable to bind to antibodies that causes ADE. After immunization with the vaccine of the present disclosure acquired from the said antigens, production of FL epitope-induced antibodies can be prevented, thereby reducing or eliminating the ADE effect.
    Type: Application
    Filed: November 9, 2020
    Publication date: May 30, 2024
    Applicant: Institute of Microbiology, Chinese Academy of Sciences
    Inventors: Fu GAO, Lianpan DAI, Jinghua YAN, Kun XU, Yuxuan HAN, Qihui WANG, Qingrui HUANG, Jinhe LI
  • Long-acting oxyntomodulin hybrid peptide, preparation method therefor, and application thereof
    Patent number: 11970523
    Abstract: The present invention discloses a polypeptide and application thereof. By modifying oxyntomodulin (OXM), hybridizing OXM with a peptide sequence of Exenatide, including enabling the polypeptide to be resistant to DPP-4 enzyme degradation through amino acid modification, and conjugating fatty acid chains at the same time, an OXM hybrid peptide having longer pharmacologic action time and better weight losing effects is obtained. Synthesis of a target polypeptide is fast realized by an orthogonal protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the OXM hybrid peptide.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: April 30, 2024
    Assignee: CHINA PHARMACEUTICAL UNIVERSITY
    Inventors: Hai Qian, Wenlong Huang, Xingguang Cai, Chengye Li, Chunxia Liu, Yuxuan Dai
  • LONG-ACTING OXYNTOMODULIN HYBRID PEPTIDE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    Publication number: 20220177537
    Abstract: The present invention discloses a polypeptide and application thereof. By modifying oxyntomodulin (OXM), hybridizing OXM with a peptide sequence of Exenatide, including enabling the polypeptide to be resistant to DPP-4 enzyme degradation through amino acid modification, and conjugating fatty acid chains at the same time, an OXM hybrid peptide having longer pharmacologic action time and better weight losing effects is obtained. Synthesis of a target polypeptide is fast realized by an orthogonal protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the OXM hybrid peptide.
    Type: Application
    Filed: May 6, 2019
    Publication date: June 9, 2022
    Inventors: Hai QIAN, Wenlong HUANG, Xingguang CAI, Chengye LI, Chunxia LIU, Yuxuan DAI