Abstract: The present disclosure relates to the field of medicine and specifically to an application of naringin combined with rapamycin in preparation of medications for treating hyperlipidemia. Naringin achieves anti-inflammatory and lipid-lowering effects by inhibiting the formation of oxLp-NLRP3 complexes. The present disclosure has been substantiated through cellular experiments and animal experiments, it demonstrates that naringin effectively intervenes in the early progression of hyperlipidemia by neutralizing oxLp and inhibiting the formation of oxLp-NLRP3 complexes. The inhibitory effect of naringin on oxLp-NLRP3 complexes contributes to unleashing the therapeutic potential of rapamycin in hyperlipidemia, providing a combined strategy for the prevention and treatment of hyperlipidemia-related diseases in clinical applications.

Abstract: Described are an encoding method and system for ROAs. The encoding method includes the following steps: given a set of authorized IP prefixes an AS which are maintained with an IP address trie. By specifying a sequence of hanging levels on the IP address trie, it is divided into a set of non-overlapping sub-trees, each rooted at a hanging level. A node on a hanging level uniquely defines a sub-tree rooted at it, whose prefix can be encoded as the identifier of this sub-tree. All authorized prefixes covered by a sub-tree can be encoded into a bitmap of 2h bits, where h is the height of this sub-tree. Thus, the set of authorized IP prefixes of an AS is encoded into several tuples (identifier, bitmap).

Abstract: Disclosed are nucleic acid-calcium phosphate nanoparticle complexes and application thereof in biomineralization. Specifically, disclosed are a biological mineralizer and a preparation method thereof. The mineralizer contains a complex formed by nucleic acid and amorphous calcium phosphate nanoparticles. Further, disclosed is a collagen fiber product containing the biological mineralizer or treated with the biological mineralizer, such as a medical device for being implanted into a patient. Further, disclosed is use of the biological mineralizer or the collagen fiber product in treatment of bone-associated diseases or disorders or improvement of bone conditions of patients. Further, disclosed is a method of using the biological mineralizer to induce biomimetic mineralization of collagen fibers or a preparation method of a mineralized collagen fiber product.