Abstract: A display device, and a display panel and a manufacturing method therefor, relating to the technical field of display. The display panel includes a substrate, a driver layer, a barrier structure, and a light-emitting layer covering the driver layer and the barrier structure and being discontinuously at least at a barrier groove of the barrier structure. The barrier structure includes a support layer, a barrier layer and a second protective layer. The barrier layer is in a different area of a same film layer than a wiring layer of the driver layer, and a side wall of the barrier layer is provided with the barrier groove surrounding the driver layer. The second protective layer is on a surface of the barrier layer away from the substrate and in a different area of a same protective film than a first protective layer of the driver layer.

Abstract: A method for manufacturing a display substrate is provided. The method includes: forming a first active layer arranged in the NMOS transistor region and a second active layer arranged in the PMOS transistor region on the base substrate; coating one side, facing away from the base substrate, of the first active layer and one side, facing away from the base substrate, of the second active layer with a first photoresist layer, forming a first pattern layer by patterning the first photoresist layer to expose at least two ends of the first active layer; forming N-type heavily doped regions by performing N-type heavy doping on the two ends of the first active layer with the first pattern layer as a mask; forming a second pattern layer by processing the first pattern layer to expose at least a middle region of the first active layer.

Abstract: A display substrate and a display device are provided. The display substrate includes: a base substrate and a plurality of sub-pixels distributed in arrays and provided on the base substrate. And the plurality of sub-pixels is divided into a plurality of sub-pixel columns. The display substrate further includes: a plurality of data lines, each of which is coupled to respective sub-pixels at a corresponding sub-pixel column; a plurality of touch electrodes and a plurality of touch signal lines coupled to corresponding touch electrodes.

Abstract: The present disclosure relates to the field of medicine and specifically to an application of naringin combined with rapamycin in preparation of medications for treating hyperlipidemia. Naringin achieves anti-inflammatory and lipid-lowering effects by inhibiting the formation of oxLp-NLRP3 complexes. The present disclosure has been substantiated through cellular experiments and animal experiments, it demonstrates that naringin effectively intervenes in the early progression of hyperlipidemia by neutralizing oxLp and inhibiting the formation of oxLp-NLRP3 complexes. The inhibitory effect of naringin on oxLp-NLRP3 complexes contributes to unleashing the therapeutic potential of rapamycin in hyperlipidemia, providing a combined strategy for the prevention and treatment of hyperlipidemia-related diseases in clinical applications.

Abstract: Disclosed are nucleic acid-calcium phosphate nanoparticle complexes and application thereof in biomineralization. Specifically, disclosed are a biological mineralizer and a preparation method thereof. The mineralizer contains a complex formed by nucleic acid and amorphous calcium phosphate nanoparticles. Further, disclosed is a collagen fiber product containing the biological mineralizer or treated with the biological mineralizer, such as a medical device for being implanted into a patient. Further, disclosed is use of the biological mineralizer or the collagen fiber product in treatment of bone-associated diseases or disorders or improvement of bone conditions of patients. Further, disclosed is a method of using the biological mineralizer to induce biomimetic mineralization of collagen fibers or a preparation method of a mineralized collagen fiber product.