Abstract: Cyclic compounds and oligopeptide compounds that selectively inhibit KRAS were found. Oligopeptide compounds and non-natural amino acids useful for producing a cyclic compound were also found. Moreover, cyclic compounds and oligopeptide compounds were found to interact with an amino acid residue specific to KRAS.

Abstract: In a data creation apparatus, a data creation method, a program, and a recording medium of the present invention, a first condition for selecting first selection image data based on the accessory information from the plurality of pieces of image data is set, the first selection image data in which the accessory information conforming to the first condition is recorded is selected from the plurality of pieces of image data, a second condition for selecting second selection image data based on the accessory information from non-selection image data that does not conform to the first condition among the plurality of pieces of image data is suggested, and the training data is created based on the first selection image data in a case where a user has not employed the second condition, and the training data is created based on the first selection image data and on the second selection image data in a case where the user has employed the second condition.

Abstract: A vehicle control system includes a detector and a processor. The detector is configured to detect a first stop line on the basis of map data stored in a road map database, and detect a second stop line on the basis of traveling environment data acquired by a camera unit. In a case where the detector detects the first stop line, the processor is configured to control a vehicle to decelerate at a first deceleration rate calculated on the basis of a distance from the vehicle to the first stop line. In a case where the detector detects the second stop line after detecting the first stop line, the processor is configured to control the vehicle to decelerate at a second deceleration rate calculated on the basis of a distance from the vehicle to the second stop line and stop at the second stop line.

Abstract: An image processing device according to the present technology includes: a foreground-background classification unit configured to classify an input image into a foreground image portion which is a portion in which a subject in a foreground is captured and a background image portion which is a portion in which a subject in a background farther than the foreground image portion is captured; a foreground correction unit configured to correct the foreground image portion; and an inconsistency correction unit configured to correct an inconsistent portion caused by the correction of the foreground image portion by the foreground correction unit.

Abstract: A device includes a processor which controls a display operation of a display unit. The processor acquires a specified portion specified by a first user operation in an object image including an object to be imaged, sets an enlargement reference point in the object image according to the specified portion with respect to which a part of the object image is enlarged when performing enlargement display control, and extracts a display target range from the object image as the part of the object image to be enlarged. The display target range includes both the enlargement reference point and the specified portion, and the enlargement reference point is set so that the representative point approaches a middle of the display area in response to each input of a second user operation for performing enlargement display control, until the representative point coincides with the middle of the display area.

Abstract: An imaging device comprises a processor configured to control a display operation of a display unit, in which the processor acquires a specified portion specified by a first user operation in an object image including an object to be imaged, performs enlargement display control of enlarging a part of the object image and displaying the enlarged part in a display area of the display unit in response to a second user operation, and sets an enlargement reference point in the object image according to the specified portion in the enlargement display control.

Abstract: A recording apparatus includes the following. A timekeeper keeps time. A recorder records data. At least one processor is configured to perform, associating the time at a timing that the data is recorded in the recorder to the data as recorded time, the time based on the kept time kept by the timekeeper, obtaining modified time regarding modification of the kept time, and in a situation that it is determined that a predetermined condition to determine whether there is a possibility that the modified time is before the recorded time associated to the latest data is satisfied, associating the time in which the kept time is not modified based on the modified time to the data recorded thereafter as the recorded time.

Abstract: A composition includes: a compound including an aromatic ring; and a first polymer including a first structural unit represented by formula (1) and a second structural unit represented by formula (2). A content of the first polymer with respect to 100 parts by mass of the compound is no less than 0.1 parts by mass and no greater than 200 parts by mass. R1 represents a hydrogen atom or a substituted or unsubstituted monovalent hydrocarbon group; and R2 represents a substituted or unsubstituted monovalent hydrocarbon group. R3 represents a hydrogen atom or a substituted or unsubstituted monovalent hydrocarbon group; L represents a single bond or a divalent linking group; Ar represents a group obtained by removing (n+1) hydrogen atoms from a substituted or unsubstituted aromatic ring; R4 represents a hydroxy group or a monovalent hydroxyalkyl group; and n is an integer of 1 to 8.

Abstract: An imaging device comprises a processor configured to control a display operation of a display unit, in which the processor acquires a specified portion specified by a first user operation in an object image including an object to be imaged, performs enlargement display control of enlarging a part of the object image and displaying the enlarged part in a display area of the display unit in response to a second user operation, and sets an enlargement reference point in the object image according to the specified portion in the enlargement display control.

Abstract: Provided is an external composition excellent in stability and impression from use. An external composition containing (A) at least one member selected from the group consisting of ascorbic acid and salts of ascorbic acid, (B) at least one member selected from the group consisting of 3-O-ethylascorbic acid, salts of 3-O-ethylascorbic acid, and hydroxylated lecithin, and (C) polyethylene glycol is prepared.

Abstract: An object of the present invention is to provide an external use composition having a novel composition that has a superior effect promoting collagen production and is able to suppress, prevent or improve wrinkles and sagging of the skin with aging. The present invention relates to an external use composition for anti-aging, comprising (A) a lipopeptide represented by the following formula (1), or a pharmaceutically acceptable salt thereof: (wherein, R1 represents a saturated aliphatic group, or aliphatic group having a single unsaturated bond, having 9 to 19 carbon atoms, and m represents 0 or 1).

Abstract: Provided is an external composition excellent in stability and impression from use. An external composition containing (A) at least one member selected from the group consisting of ascorbic acid and salts of ascorbic acid, (B) at least one member selected from the group consisting of 3-O-ethylascorbic acid, salts of 3-O-ethylascorbic acid, and hydroxylated lecithin, and (C) polyethylene glycol is prepared.

Abstract: An object of the present invention is to provide an external use composition having a novel composition that has a superior effect promoting collagen production and is able to suppress, prevent or improve wrinkles and sagging of the skin with aging. The present invention relates to an external use composition for anti-aging, comprising (A) a lipopeptide represented by the following formula (1), or a pharmaceutically acceptable salt thereof: (wherein, R1 represents a saturated aliphatic group, or aliphatic group having a single unsaturated bond, having 9 to 19 carbon atoms, and m represents 0 or 1).

Abstract: An arctigenin derivative used for anti-aging treatment, including protection of the skin from the sun and recovery of skin elasticity. A variety of fatty acid ester derivatives, alcohol ether derivatives and alkylated derivatives are used as the arctigenin derivatives. Agents for controlling ET-1 production, elastase inhibitors, and anti-inflammatory agents are prepared. Such arctigenin derivatives are particularly useful as an external agent for the skin, such as an anti-inflammatory external agent, a sunscreen external agent, or an external agent for recovering elasticity.

Abstract: An arctigenin derivative used for anti-aging treatment, including protection of the skin from the sun and recovery of skin elasticity. A variety of fatty acid ester derivatives, alcohol ether derivatives and alkylated derivatives are used as the arctigenin derivatives. Agents for controlling ET-1 production, elastase inhibitors, and anti-inflammatory agents are prepared. Such arctigenin derivatives are particularly useful as an external agent for the skin, such as an anti-inflammatory external agent, a sunscreen external agent, or an external agent for recovering elasticity.