Patents by Inventor Yuying Yuan

Yuying Yuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240013931
    Abstract: Provided are an NLP-based method for constructing a variant literature interpretation knowledge base, an interpretation method, and an electronic device. The method for constructing the variant literature interpretation knowledge base includes: obtaining disease-related literature; constructing, based on the disease-related literature, a database of entities associated with genes and variants; constructing a literature evidence knowledge graph for interpretation of variant literature; and performing evidence extraction on the literature evidence knowledge graph to obtain evidence corresponding to an entity, and constructing, based on the evidence and the database, the variant literature interpretation knowledge base. In this way, the literature evidences can be more comprehensive and systematic.
    Type: Application
    Filed: September 26, 2023
    Publication date: January 11, 2024
    Applicant: BGI GENOMICS CO., LTD.
    Inventors: Daoling HUANG, Quanlei ZENG, Yun XIONG, Shuixia LIU, Yuying YUAN, Ning LI
  • Publication number: 20220336047
    Abstract: Provided is a method for determining whether a fetus has chromosomal aneuploidy, the method comprising: the method comprises: (1) obtaining nucleic acid sequencing data from a pregnant woman sample; (2) determining a fetal fraction of the pregnant woman sample and an estimated fraction by a predetermined chromosome based on the nucleic acid sequencing data; (3) determining a first feature based on a difference between the estimated fraction by a chromosome to be tested and the estimated fraction by a second comparison chromosome, and determining a second feature based on a difference between the estimated fraction by the chromosome to be tested and the fetal fraction; and (4) determining whether the fetus has an aneuploidy for the chromosome to be tested based on the first feature and the second feature by using corresponding data of control sample, wherein the control sample comprises a positive sample and a negative sample, the positive sample has an aneuploidy for the chromosome to be tested, and the negat
    Type: Application
    Filed: December 31, 2019
    Publication date: October 20, 2022
    Inventors: Hongyun ZHANG, Yuying YUAN, Xianghua CHAI, Lijun ZHOU, Mengjie WANG, Qiang LIU, Ye YIN
  • Publication number: 20180082012
    Abstract: Provided in the present disclosure are a method and a device for determining a fraction of cell free nucleic acids in a biological sample and use thereof, wherein the method comprises: (1) sequencing nucleic acids of a biological sample having free nucleic acids, in order to obtain sequencing results for a plurality of sequencing data; (2) based on the sequencing results, determining the number of nucleic acid molecules with a length falling within a preset range in the sample; and (3) based on the number of nucleic acid molecules with a length falling within the preset range, determining the ratio of free nucleic acids in the biological sample.
    Type: Application
    Filed: July 24, 2015
    Publication date: March 22, 2018
    Inventors: Fuman Jiang, Yuying Yuan, Wei Wang, Ye Yin
  • Patent number: 9547748
    Abstract: The current invention is directed to methods for noninvasive detection of fetal genetic abnormalities by large-scale sequencing of nucleotides from maternal biological sample. Further provided are methods to remove GC bias from the sequencing results according to the difference in GC content of a chromosome. The current invention not only makes the detection much more accurate but also represents a comprehensive method for fetal aneuploidy detection including sex chromosome disorders such as XO, XXX, XXY, and XYY, etc.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: January 17, 2017
    Assignee: BGI HEALTH SERVICE CO., LTD.
    Inventors: Fuman Jiang, Huifei Chen, Xianghua Chai, Yuying Yuan, Xiuqing Zhang, Fang Chen
  • Publication number: 20140099642
    Abstract: The current invention is directed to methods for noninvasive detection of fetal genetic abnormalities by large-scale sequencing of nucleotides from maternal biological sample. Further provided are methods to remove GC bias from the sequencing results according to the difference in GC content of a chromosome. The current invention not only makes the detection much more accurate but also represents a comprehensive method for fetal aneuploidy detection including sex chromosome disorders such as XO, XXX, XXY, and XYY, etc.
    Type: Application
    Filed: June 29, 2011
    Publication date: April 10, 2014
    Applicant: BGI SHENZHEN CO., LIMITED
    Inventors: Fuman Jiang, Huifei Chen, Xianghua Chai, Yuying Yuan, Xiuqing Zhang, Fang Chen