Abstract: For assembling a heat pump, an apparatus includes a loading part located in an initial section of the fully automatic intelligent production line of an integrated thermal management module. The apparatus includes a first assembling part, located downstream of the loading part, that assembles a refrigerant side components of the heat pump. The apparatus includes a first testing part, located downstream of the first assembly part, that tests the refrigerant side components. The apparatus includes a second assembling part, located downstream of the loading part, that assembles the cooling water side components of the heat pump. The apparatus includes a second testing part, located downstream of the second assembling part, that tests the cooling water side components. The apparatus includes a finished product part, located downstream of the second testing part, that outputs a finished product.

Abstract: This application provides a protein structure information prediction method and apparatus, a device, and a storage medium, and relates to the field of biological information technologies. The method includes: performing sequence alignment query in a first database according to an amino acid sequence of a protein to obtain multi-sequence aligned data; performing feature extraction on the multi-sequence aligned data to obtain an initial sequence feature; processing the initial sequence feature by using a sequence feature augmentation model to obtain an augmented sequence feature of the protein; and predicting structure information of the protein according to the augmented sequence feature. When the structure information of the protein is predicted based on artificial intelligence (AI), the foregoing solution can improve the prediction efficiency of protein structure information while ensuring the prediction accuracy of the protein structure information.

Abstract: A fluorinated 2-arylbenzo heterocyclic compound with high affinity to A? plaques and containing a chiral side chain substituent, has a general formula (I) as follows: wherein X is N; Y is S or O; Z is N or CH; R1 is a 5 or 6-substituent and is F is 19F or 18F; R2 is NHCH3 or N(CH3)2. The compound of the present invention has high affinity to A? plaques and can be used to make appropriate radioactive nuclide labeling probes for early diagnosis of AD.

Abstract: Parts of compounds, after being labeled by radionuclide, of the phenyl benzyl ether derivative, are used as A? plaque imaging agent. The structural formula of the phenyl benzyl ether derivative is shown by formula (I). The present invention develops a kind of brand new phenyl benzyl ether derivative which has high affinity with A? plaques in brains of AD patients. The chemical structure of the phenyl benzyl ether derivative is different from that of compounds disclosed in the prior art and the phenyl benzyl ether derivative belongs to a brand new compound for diagnosing and treating AD. The obtained A? plaque imaging agent has the advantages that the in-vivo stability is good, the fat solubility is low, the removal speed for the brain is fast, the problem of removing the radionuclide in vivo does not exist, and the application prospect and the market value are great.

Abstract: A fluorinated 2-arylbenzo heterocyclic compound with high affinity to A? plaques and containing a chiral side chain substituent, has a general formula (I) as follows: wherein X is N; Y is S or O; Z is N or CH; R1 is a 5 or 6-substituent and is F is 19F or 18F; R2 is NHCH3 or N(CH3)2. The compound of the present invention has high affinity to A? plaques and can be used to make appropriate radioactive nuclide labeling probes for early diagnosis of AD.