Patents by Inventor Yuzhi Liu

Yuzhi Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYGONI MILLETII RHIZOME COMPOSITIONS AND METHODS OF PREPARING THE SAME
    Publication number: 20230022609
    Abstract: A method of preparing a Polygoni Milletii Rhizome tincture includes: preparing a first mixture; extracting the first mixture with 70-90% ethanol under reflux condition to obtain a first extract solution; preparing a second mixture; extracting the second mixture with 50-70% ethanol to obtain a second extract solution; and mixing the first extract solution with the second extract solution to obtain the polygoni milletii rhizome tincture. A method of preparing a Polygoni Milletii Rhizome poultice includes: reparing a Polygoni Milletii Rhizome mixture; mixing the Polygoni Milletii Rhizome mixture and a skin penetration enhancer in water; mixing a moisturizing agent and a binder in water; adding a thickener in water; mixing methylparaben and ethylparaben in 90% ethanol; mixing all solutions to form a mixture; and applying the mixture on a non-woven fabric cloth and drying to form the Polygoni Milletii Rhizome poultice.
    Type: Application
    Filed: July 1, 2022
    Publication date: January 26, 2023
    Inventors: Xiaolin XIE, Dezhu ZHANG, Chengyuan LIANG, Shujun DING, Yuzhi LIU, Zhao MA, Xuhua ZHOU, Zhong MENG, Jianguo MENG
  • Silibinin lipoic acid ester with hepatoprotective activity and a method of preparing the same
    Patent number: 11306076
    Abstract: A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: April 19, 2022
    Assignee: XI'AN TAIKOMED PHARMACEUTICAL TECHNOLOGY CO., LTD.
    Inventors: Yonghong Tang, Huafeng Qi, Peiyu Zhou, Xingke Ju, Chengyuan Liang, Yuzhi Liu, Bin Tian, Lei Tian, Gennian Mao, Limei Wang, Yuanyuan He, Yongbo Wang, Jingwen Xu, Dan Yang, Liang Qi, Wenbo Yao, Qianqian Zhao, Han Li
  • SILIBININ LIPOIC ACID ESTER WITH HEPATOPROTECTIVE ACTIVITY AND A METHOD OF PREPARING THE SAME
    Publication number: 20210347767
    Abstract: A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.
    Type: Application
    Filed: May 11, 2020
    Publication date: November 11, 2021
    Applicant: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Xingke JU, Chengyuan LIANG, Yuzhi LIU, Bin TIAN, Lei TIAN, Gennian MAO, Limei WANG, Yuanyuan HE, Yongbo WANG, Jingwen XU, Dan YANG, Liang QI, Wenbo YAO, Qianqian ZHAO, Han LI
  • Methods of using 1-O-acetylbritannilatone spiro aryl isoxazoline compounds
    Patent number: 11028102
    Abstract: A method of inhibiting leukotriene include: administrating a therapeutically effective amount of a compound of chemical formula I or II or a pharmaceutical acceptable salt thereof to a subject, R1 is OH or OAc; X is C or N; and R2 is H, alkyl, alkoxy, benzyloxy, haloalkyl, OH, CN, NO2, or halogen, provided that when X is N, R2 is nil.
    Type: Grant
    Filed: February 29, 2020
    Date of Patent: June 8, 2021
    Assignee: XI'AN TAIKOMED PHARMACEUTICAL TECHNOLOGY CO., LTD.
    Inventors: Yonghong Tang, Minghui Chang, Huafeng Qi, Chengyuan Liang, Xingke Ju, Lei Tian, Yuzhi Liu, Han Li
  • Hydroxytyrosol ursolic acid ester with antioxidant activity and methods of preparing the same
    Patent number: 10995053
    Abstract: A compound having the formula (I): is disclosed. Methods of preparing the compound of formula (I) are also disclosed. The compound of formula (I) can be prepared by reacting a compound of formula (II) with a compound of formula (III) in an organic solvent with EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide). The compound of formula (I) can also be prepared by reacting the compound of formula (II) with the compound of formula (III) in 1-ethyl-3-methylimidazolium hexafluorophosphate as a solvent with silicomolybdic acid as a catalyst.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: May 4, 2021
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Han Li, Nan Hui, Bin Tian, Xingke Ju, Yuzhi Liu, Dan Yang, Jingwen Xu, Liang Qi, Qianqian Zhao, Yongbo Wang
  • Silibinin 3,3?-thiodipropionic acid ester with hepatoprotective activity and a method of preparing the same
    Patent number: 10766885
    Abstract: A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: September 8, 2020
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Xingke Ju, Chengyuan Liang, Bin Tian, Yuzhi Liu, Lei Tian, Gennian Mao, Limei Wang, Yuanyuan He, Yongbo Wang, Jingwen Xu, Dan Yang, Liang Qi, Wenbo Yao, Qianqian Zhao, Han Li
  • Gossypol isatin schiff base compounds with antitumor activities and a method of preparing the same
    Patent number: 10729675
    Abstract: A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: August 4, 2020
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Chengyuan Liang, Xingke Ju, Shunjun Ding, Lei Tian, Yuzhi Liu, Xiaolin Xie, Dezhu Zhang, Wenbo Yao, Dan Yang
  • METHODS OF USING 1-O-ACETYLBRITANNILATONE SPIRO ARYL ISOXAZOLINE COMPOUNDS
    Publication number: 20200199152
    Abstract: A method of inhibiting leukotriene include: administrating a therapeutically effective amount of a compound of chemical formula I or II or a pharmaceutical acceptable salt thereof to a subject, R1 is OH or OAc; X is C or N; and R2 is H, alkyl, alkoxy, benzyloxy, haloalkyl, OH, CN, NO2, or halogen, provided that when X is N, R2 is nil.
    Type: Application
    Filed: February 29, 2020
    Publication date: June 25, 2020
    Inventors: Yonghong TANG, Minghui CHANG, Huafeng QI, Chengyuan LIANG, Xingke JU, Lei TIAN, Yuzhi LIU, Han LI
  • Alantolactone/isoalantolactone spiro aryl isoxazoline compounds
    Patent number: 10662201
    Abstract: A compound of chemical formula I: or chemical formula II: or a pharmaceutical acceptable salt thereof is disclosed. R1, R2, R3, and R4 are independently H, halogen, nitro, hydroxyl, cyano, benzyloxy, C1-C8 straight or branched alkyl, C1-C8 straight or branched haloalkyl, C1-C8 straight or branched alkoxy.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: May 26, 2020
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Chengyuan Liang, Xingke Ju, Lei Tian, Nan Qin, Juan Xia, Shaomeng Pei, Han Li, Yuzhi Liu
  • GOSSYPOL ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME
    Publication number: 20200147042
    Abstract: A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.
    Type: Application
    Filed: February 7, 2019
    Publication date: May 14, 2020
    Applicant: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Chengyuan LIANG, Lei TIAN, Shunjun DING, Xingke JU, Yuzhi LIU, Xiaolin XIE, Dezhu ZHANG
  • 1-O-acetylbritannilatone spiro aryl isoxazoline compounds
    Patent number: 10618911
    Abstract: A compound of chemical formula I: or formula II: or a pharmaceutical acceptable salt thereof is disclosed. R1 is OH or OAc; X is C or N; and R2 is H, alkyl, alkoxy, benzyloxy, haloalkyl, OH, CN, NO2, or halogen, provided that when X is N, R2 is nil.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: April 14, 2020
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Han Li, Yuzhi Liu, Nan Qin, Juan Xia, Shaomeng Pei, Chengyuan Liang, Lei Tian
  • Bergenin thiodipropionic acid ester with antioxidant activity and a method of improving the antioxidant property of ganoderma lucidum spore oil using the same
    Patent number: 10487094
    Abstract: A compound having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.
    Type: Grant
    Filed: September 3, 2018
    Date of Patent: November 26, 2019
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Chengyuan Liang, Yuzhi Liu, Danni Tian, Jie Li, Songsong Ruan, Han Li, Qianqian Zhao, Xuechuan Wang, Xeufeng Chen
  • Dihydroxytyrosol hexamethylene-1,6-dicarbamate having antioxidant activity and a method of preparing the same
    Patent number: 10487046
    Abstract: A compound having the following formula I: is disclosed. A method of preparing the compound of formula (I) is also disclosed.
    Type: Grant
    Filed: July 13, 2019
    Date of Patent: November 26, 2019
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Han Li, Yuzhi Liu, Xingke Ju, Lei Tian, Juan Li, Nan Hui, Guaiping Qiao, Ning Liu, Liuyi Yang, Xuefeng Chen
  • Hydroxytyrosol p-phenylenedicarboxylate having antioxidant activity and a method of preparing the same
    Patent number: 10472321
    Abstract: A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.
    Type: Grant
    Filed: July 13, 2019
    Date of Patent: November 12, 2019
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Chengyuan Liang, Yuzhi Liu, Xingke Ju, Yonghong Tang, Minghui Chang, Bin Tian, Dan Yang, Han Li, Ning Liu, Huayin Pu, Jian Cha, Juanna Song, Yongbo Wang
  • Hydroxytyrosol isophorone diisocyannate derivative with antioxidant activity and a method of preparing the same
    Patent number: 10377702
    Abstract: A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: August 13, 2019
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Chengyuan Liang, Yuzhi Liu, Xingke Ju, Yonghong Tang, Gennian Mao, Qianqian Zhao, Bin Tian, Jian Zha, Chunyang Shi, Yongbo Wang, Huayin Pu, Yanghan Liu
  • Hydroxytyrosol thiodipropionic acid ester with antioxidant activity and a method of preparing the same
    Patent number: 10343988
    Abstract: A compound having the following formula I: is disclosed. A method of preparing the compound of formula I is also disclosed.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: July 9, 2019
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Chengyuan Liang, Lei Tian, Danni Tian, Yuzhi Liu, Xingke Ju, Nan Hui, Mi Wu, Juan Li, Han Li, Bin Tian, Qianqian Zhao
  • Hydroxytyrosol shikimic acid ester for treating cardiovascular deceases and a method of preparing the same
    Patent number: 10336682
    Abstract: A compound having the following formula I: is disclosed. A method of preparing the compound of formula I is also disclosed.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: July 2, 2019
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Chengyuan Liang, Lei Tian, Yuzhi Liu, Xingke Ju, Nan Hui, Mi Wu, Juan Li, Han Li, Bin Tian, Qianqian Zhao, Gennian Mao, Nan Qin, Juan Xia, Zhenfeng Shi
  • 13-hydroxysparteine cinnamic acid derivatives with anti-tumor activities and a method of preparing the same
    Patent number: 10233183
    Abstract: A compound having the following formula I: In formula I, R1 and R2 are independently H, alkyl, alkoxy, and halogen. A method of preparing the compound of formula I is also disclosed.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: March 19, 2019
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Chengyuan Liang, Lei Tian, Yonghong Tang, Minghui Chang, Kaiqi Shi, Xingke Ju, Yuzhi Liu, Lili Wen, Han Li, Xuechuan Wang
  • Toilet inlet valve and control method thereof
    Patent number: 9422699
    Abstract: A toilet inlet valve and control method thereof, the inlet valve comprises a valve body, an inlet pipe, a water stop device with a water stop rubber gasket, a float bowl device, a raising rod device and an outlet pipe, wherein, the water stop device also comprises a water stop seat, a tray, a needle valve and a back pressure cavity; the water stop seat is located at the front end of the outlet pipe, and of which the opening is coupling with the end face of the water stop rubber gasket; the tray is connected to the water stop rubber gasket, and is located at the side of the water stop seat that is opposite to the water stop rubber gasket; the needle valve is fixed to the tray, and is located at the side of the water stop rubber gasket that is opposite to the tray.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: August 23, 2016
    Assignee: WDI (XIAMEN) TECHNOLOGY INC.
    Inventors: Feiyu Li, Dongsheng Yao, Yuzhi Liu
  • Water intake structure for water-storing key float
    Patent number: 9062443
    Abstract: The present invention discloses an inlet structure of water-storing keg float, comprises an inlet, an outlet pipe and a water-storing keg float with a storage tank, and the inlet is provided with a channel passing through the outlet pipe, and the channel is provided with a water-storing cavity and a guide hole, and the guide hole is communicated with the water-storing cavity and the outside wall of the outlet pipe. Because water-storing cavity is present, part of water from the inlet can be stored in the water-storing cavity because of gravity, and this part of water fully enters the storage tank of the keg float through the guide hole, and the keg float can be balanced effectively under different water pressure conditions, and the stability of the keg float is enhanced.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: June 23, 2015
    Inventors: Feiyu Li, Dongsheng Yao, Yuzhi Liu