Abstract: The purpose of the present invention is to provide a novel stereoselective method for preparing a cyclic dinucleotide derivative and a production intermediate therefor, which can be used for an antibody-immunostimulant conjugate. Also provided is a method for producing a cyclic dinucleotide-linker and an antibody-immunostimulant conjugate while using the above production method. Further provided is a method for preparing a cyclic dinucleotide derivative, the method including the step of subjecting a compound (I) and a compound (IV) to stereoselective condensation using an optically active phosphitylating agent (Rc-II) or (Sc-II).

Abstract: The present invention provides a crystalline 2,4-bridged common intermediate useful for producing a plurality of ENA monomers, a method for stereoselectively producing the intermediate, and a method for efficiently producing ENA monomers using the intermediate.

Abstract: A method for producing a 1-(acyloxy)alkyl carbamate derivative (III), using a fluorous alkyl carbonate derivative (I), and a fluorous alkyl carbonate derivative (I) and a method for producing the same. In the formula, R1 represents C1-C4 alkyl group or a C3-C6 cycloalkyl group, R2 represents a C1-C4 alkyl group or a hydrogen atom, and A represents a fluorous alkyl group (wherein the fluorous alkyl group represents a C2-C11 alkyl group in which 40% or more of the hydrogen atoms are replaced by fluorine atoms).

Abstract: A method for producing a 1-(acyloxy)alkyl carbamate derivative (III), using a fluorous alkyl carbonate derivative (I), and a fluorous alkyl carbonate derivative (I) and a method for producing the same. In the formula, R1 represents C1-C4 alkyl group or a C3-C6 cycloalkyl group, R2 represents a C1-C4 alkyl group or a hydrogen atom, and A represents a fluorous alkyl group (wherein the fluorous alkyl group represents a C2-C11 alkyl group in which 40% or more of the hydrogen atoms are replaced by fluorine atoms).

Abstract: In a finishing apparatus, a plurality of works are retained at distances from each other in a direction of an X-axis. A single spindle is disposed on a table movable in the direction of the X-axis, the spindle has an axis parallel to an axis of each of bores to be finished, and is capable of being advanced and retracted axially. A measuring device is provided that measures an inside diameter of each finished bore and which is advanced and retracted independently from the spindle in a direction along the axis of each finished bore. A combination tool is mounted at a tip end of the spindle and finishes an inner surface of any of the bores to be finished, even if the position of insertion of the combination tool into each of the bores is changed.

Abstract: An automatic assembling apparatus is provided for assembling in sequence at least a first component and a second component to an article at an assembling station. The assembling apparatus comprises a first assembling jig for the first assembling component and a second assembling jig for the second component. An annular rail has the first and second assembling jigs mounted thereon such that they are circumferentially movable on the annular rail. The annular rail has a movable rail portion positioned opposite the assembling station which is movable to advance toward and retract from the assembling station. At least one supplying station is positioned with respect to the circumference of the annular rail for supplying components to the assembling jigs at the supplying station.

Abstract: A cover over the screw shaft in a roller-type fingerpressure apparatus prevents clogging and is also provided with flanges to help guide the moving roller frame. The vertical extension of the rollers is enhanced by having the roller shafts vertically slidable in grooves formed in plates which are themselves vertically slidable with respect to the frame.

Abstract: Therein is disclosed a method for assembling a uniform-speed joint having an inner rotary body and an outer rotary body which transmits a rotational force from one to the other through a plurality of small spheres in receiving holes on the disposed outer peripheral surface of said inner rotary body and including a pair of small spheres diametrically facing each other where the intersecting angle between the rotation axes of said inner rotary body and said outer rotary body is variable and the rotational speed is not changed.