Patents by Inventor Yuzuru Ishimura

Yuzuru Ishimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody recognizing human 25-hydroxyvitamin D3-1a-hydroxylase
    Publication number: 20020031798
    Abstract: The present invention relates to a polypeptide having 25-hydroxyvitamin D3-1&agr;-hydroxylase activity, being useful for the prevention, diagnosis and therapeutic treatment of adult diseases such as osteoporosis induced by the decrease of active type vitamin D3 and catalyzing the final stage of vitamin D3 activation; and the gene encoding the polypeptide.
    Type: Application
    Filed: June 12, 2001
    Publication date: March 14, 2002
    Inventors: Hideharu Anazawa, Hiroko Shimada, Seiji Sugimoto, Tatsuo Suda, Toshimasa Shinki, Takao Saruta, Yuzuru Ishimura, Matsuhiko Hayashi, Shu Wakino, Toshiaki Monkawa, Tadashi Yoshida, Hiromichi Suzuki
  • 25-hydroxyvitamin D3-1&agr;-hydroxylase and DNA encoding the hydroxylase
    Patent number: 6274359
    Abstract: The present invention relates to a polypeptide having 25-hydroxyvitamin D3-1&agr;-hydroxylase activity, being useful for the prevention, diagnosis and therapeutic treatment of adult diseases such as osteoporosis induced by the decrease of active type vitamin D3 and catalyzing the final stage of vitamin D3 activation; and the gene encoding the polypeptide. In accordance with the present invention, the following can be provided; a polypeptide having 25-hydroxyvitamin D3-1&agr;-hydroxylase activity, DNA encoding the polypeptide, a recombinant DNA prepared by inserting the DNA in a vector, a transformant carrying the recombinant DNA, a method for preparing 25-hydroxyvitamin D3-1&agr;-hydroxylase by using the transformant, a method for preparing 1&agr;, 25-dihydroxyvitamin D3 comprising using the polypeptide having 25-hydroxyvitamin D3-1&agr;-hydroxylase activity, and an antibody recognizing the polypeptide.
    Type: Grant
    Filed: July 8, 1998
    Date of Patent: August 14, 2001
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hideharu Anazawa, Hiroko Shimada, Seiji Sugimoto, Tatsuo Suda, Toshimasa Shinki, Takao Saruta, Yuzuru Ishimura, Matsuhiko Hayashi, Shu Wakino, Toshiaki Monkawa, Tadashi Yoshida, Hiromichi Suzuki
  • Method for preserving a liver by perfusion with or storage in a solution containing ascorbyl tocopheryl phosphodiester
    Patent number: 5660976
    Abstract: This invention provides a hepatic graft preservative composition containing a phosphoric acid diester compound of the formula: ##STR1## (wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a methyl group) or a pharmacologically acceptable salt thereof and a method for viable preservation of the hepatic graft using the above substance.The hepatic graft preservative composition and hepatic graft preserving method of this invention inhibit hepatic microcirculation disturbance following cold storage-reperfusion of the liver to effectively prevent necrosis of hepatocytes and is, therefore, useful for the preservation of the hepatic graft.
    Type: Grant
    Filed: June 13, 1995
    Date of Patent: August 26, 1997
    Assignee: Senju Pharmaceutical Co., Ltd.
    Inventors: Yuzuru Ishimura, Makoto Suematsu, Kenichi Yoshida