Patents by Inventor Yuzuru Matsuda
Yuzuru Matsuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6642355Abstract: The invention relates to an endothelin antagonistic peptide of the formula (I): X-A-Trp-B-Gly-Thr-E-G-Y (I) SEQ ID NO: 2 wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X1-Gly or and Y represents hydroxy, lower alkoxy, amino, wherein X1, X3, Y1, Y2 and Z are further defined, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 2, 2001Date of Patent: November 4, 2003Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
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Patent number: 6593304Abstract: The present invention relates to recombinant DNA comprising DNA coding for smooth-muscle-type myosin heavy chain SM1 isoform protein inserted into vector DNA, a microorganism carrying the recombinant DNA, and an agent for treatment of arteriosclerosis comprising the recombinant DNA. The recombinant DNA of the present invention can be used effectively as an agent for gene therapy of restenosis after PTCA treatment.Type: GrantFiled: July 25, 1997Date of Patent: July 15, 2003Assignees: Vessell Research Laboratory Co. Ltd., Osaka Prefectual GovernmentInventors: Kazuhide Hasegawa, Emi Arakawa, Shoji Oda, Yuzuru Matsuda, Katsuhito Takahashi, Michihiro Sugahara, Haruo Ishiyama
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Publication number: 20030055213Abstract: Disclosed in a peptide represented by the following formula (I):Type: ApplicationFiled: January 2, 2001Publication date: March 20, 2003Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
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Patent number: 6489331Abstract: A medicament for the therapeutic treatment of diabetes which comprises as an active ingredient a compound represented by the general formula (I): wherein R1 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, R2 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, R3 represents a hydrogen atom, a lower alkyl group or a substituted or unsubstituted aralkyl group, X1 and X2 independently represent a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and the symbol “n” represents an integer of from 0 to 3, or a physiologically acceptable salt thereof.Type: GrantFiled: April 9, 2001Date of Patent: December 3, 2002Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Junichi Shimada, Yoshihisa Ohta, Kotaro Takasaki, Miho Suda, Hideaki Kusaka, Hiroshi Yano, Satoshi Nakanishi, Yuzuru Matsuda
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Patent number: 6194195Abstract: The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.Type: GrantFiled: October 27, 1998Date of Patent: February 27, 2001Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
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Patent number: 5874592Abstract: The present invention relates to a novel compound EI-2128-1 having IL-1 production inhibitory activity which is represented by formula (I): ##STR1##Type: GrantFiled: November 12, 1997Date of Patent: February 23, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takeo Tanaka, Fumito Koizumi, Tsutomu Agatsuma, Hidemasa Kondo, Yutaka Saitoh, Katsuhiko Ando, Yuzuru Matsuda
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Patent number: 5804599Abstract: Provided is an Interleukin-1 production inhibiting compound represented by formula (I) ##STR1## wherein R denotes 4-methyl-1-pentenyl, 5-methyl-1,3-heptadienyl or 1-methylpentanyl.Type: GrantFiled: September 27, 1995Date of Patent: September 8, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takeo Tanaka, Eiji Tsukuda, Keiko Ochiai, Katsuhiko Ando, Hidemasa Kondo, Youichi Uosaki, Yutaka Saitoh, Yuzuru Matsuda, Fumito Koizumi, Tsutomu Agatsuma
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Patent number: 5756494Abstract: The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.Type: GrantFiled: June 2, 1995Date of Patent: May 26, 1998Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Michael E. Lewis, James C. Kauer, Nicola Neff, Jill Roberts-Lewis, Chikara Murakata, Hiromitsu Saito, Yuzuru Matsuda, Marcie A. Glicksman, Fumihiko Kanai, Masami Kaneko
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Patent number: 5741808Abstract: The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.Type: GrantFiled: February 14, 1997Date of Patent: April 21, 1998Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Michael E. Lewis, James C. Kauer, Nicola Neff, Jill Roberts-Lewis, Chikara Murakata, Hiromitsu Saito, Yuzuru Matsuda, Marcie A. Glicksman, Fumihiko Kanai, Masami Kaneko
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Patent number: 5686485Abstract: The present invention relates to EI-1941 compounds having interleukin-1 production inhibitory activity which are represented by the formula: ##STR1## wherein either of R.sup.1 and R.sup.2 is hydrogen and the other is hydroxy, or R.sup.1 and R.sup.2 together represent oxygen; and R.sup.3 is hydroxy and R.sup.4 is hydrogen, or R.sup.3 and R.sup.4 together represent --0--.Type: GrantFiled: October 9, 1996Date of Patent: November 11, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takeo Tanaka, Hidemasa Kondo, Fumito Koizumi, Hiroki Ishiguro, Mayumi Yoshida, Katsuhiko Ando, Yuzuru Matsuda
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Patent number: 5639860Abstract: Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 represents hydroxy;and Z represents, in case of (1),Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z.sup.1Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1,Trp-Phe-Phe-Asn-Tyr-R-T-Z.sup.1wherein Z.sup.1 is an organic moiety,wherein R is Tyr or a covalent bond,T is Trp, Ala, Phe, Tyr, Trp-Trp, Asn-Tyr-Tyr-Trp, Trp-Asn-Tyr-Tyr-Trp, Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp,or in case of (2), Z representsTrp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1.Type: GrantFiled: October 12, 1994Date of Patent: June 17, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
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Patent number: 5621100Abstract: The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.Type: GrantFiled: October 26, 1994Date of Patent: April 15, 1997Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Michael E. Lewis, James C. Kauer, Nicola Neff, Jill Roberts-Lewis, Chikara Murakata, Hiromitsu Saito, Yuzuru Matsuda, Marcie A. Glicksman, Fumihiko Kanai, Masami Kaneko
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Patent number: 5621101Abstract: The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.Type: GrantFiled: June 7, 1995Date of Patent: April 15, 1997Assignees: Cephalon, Inc., Kyowa Hakko KogyoInventors: Michael E. Lewis, James C. Kauer, Nicola Neff, Jill Roberts-Lewis, Chikara Murakata, Hiromitsu Saito, Yuzuru Matsuda, Marcie A. Glicksman, Fumihiko Kanai, Masami Kaneko
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Patent number: 5461146Abstract: The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. Also, a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.Type: GrantFiled: July 22, 1993Date of Patent: October 24, 1995Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Michael E. Lewis, James C. Kauer, Nicola Neff, Jill Roberts-Lewis, Chikara Murakata, Hiromitsu Saito, Yuzuru Matsuda, Marcie A. Glicksman
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Patent number: 5132112Abstract: Compounds comprising a linear .beta.1.fwdarw.6 glucan esterified by caproic acid, the number of D-glucose residues being from 7 to 40 and the number of caproic acid residues being from 2 to 30, may be be obtained by fermentation of a microorganism of the genus Aureobasidium. These compounds are designated HS-142-1. Preferred microorganism is Aureobasidium pullulans var. melanigenum KAC-2383 (FERM-BP 2407).The compounds of the present invention exhibit excellent antagonistic activity to ANP and are capable of inhibiting the bonding of ANP to ANP receptors.Type: GrantFiled: April 9, 1991Date of Patent: July 21, 1992Assignee: Kyowa Hakko Kogyo Kabushiki KaishaInventors: Yoshikazu Morishita, Mitsuru Takahashi, Koji Yamada, Tomoyuki Sano, Isao Kawamoto, Katsuhiko Ando, Hiroshi Sano, Yutaka Saito, Hiroshi Kase, Yuzuru Matsuda
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Patent number: 5081264Abstract: A compound of formula (I): ##STR1## wherein R.sub.1 represents hydrogen, hydroxy or acetoxy and R.sub.2 represents hydroxy or acetoxy.The compounds are capable of protecting the nerve cells and also antagonistic activity against N-methyl-D-aspartic acid receptors.They may be prepared by fermentation of a microorganism of the genus Verticillium or a mutant thereof.Type: GrantFiled: September 18, 1990Date of Patent: January 14, 1992Assignee: Kyowa Hakko Kabushiki KaishaInventors: Shinichiro Toki, Mika Nozawa, Mayumi Yoshida, Hiroshi Sano, Katsuhiko Ando, Isao Kawamoto, Yuzuru Matsuda, Junichi Ikeda, Kazuhiro Kubo
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Patent number: 4692310Abstract: A new substance K-259-2 having a molecular formula of C.sub.21 H.sub.18 O.sub.7, a molecular weight of 382 and an elemental analysis (%) of H: 4.50, C: 65.53 and N: 0. This substance is of interest in providing a new vasodilating agent in view of its ability to dilate the blood vessel, particularly the artery, of mammals. This substance may be obtained by fermentation of a microorganism Micromonospora sp. K-259 (FERM BP 569).Type: GrantFiled: April 16, 1986Date of Patent: September 8, 1987Assignee: Kyowa Hakko Kogyo Kabushiki KaishaInventors: Hiroshi Kase, Yuzuru Matsuda, Isao Kawamoto, Kozo Asano, Kunikatsu Shirahata, Tohru Yasuzawa, Koji Yamada
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Patent number: 4555402Abstract: A novel physiologically active substance K-252 having an antiallergic action is produced by culturing a microorganism of the genus Nocardiopsis.Type: GrantFiled: August 10, 1984Date of Patent: November 26, 1985Assignee: Kyowa Hakko Kogyo Co. Ltd.Inventors: Yuzuru Matsuda, Kazuyuki Iwahashi, Takao Iida, Noriaki Hirayama, Kozo Asano, Katsuichi Shuto, Koji Yamada, Kunikatsu Shirahata, Hiroshi Kase
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Patent number: 4438197Abstract: The antibacterial compound DC-38-V is produced by culturing a microorganism belonging to the genus Streptomyces.Type: GrantFiled: April 16, 1982Date of Patent: March 20, 1984Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fusao Tomita, Yuzuru Matsuda, Kunikatsu Shirahata, Keiichi Takahashi, Hirofumi Nakano, Tomoyasu Sato, Shuji Okubo, Nobuo Nakamura