Patents by Inventor Yvan Guindon

Yvan Guindon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ribonucleotide reductase inhibitors
    Patent number: 5071835
    Abstract: Disclosed herein are peptides of the formulaY--R.sup.1 --R.sup.2 --R.sup.3 --R.sup.4 --R.sup.5 --R.sup.6 --Zwherein R.sup.1 to R.sup.5 are designated amino acid residues; R.sup.6 is Phe, homoPhe or an amino acid residue derived from 2-amino-3-cyclohexylpropionic acid, 2-amino-3-(4-(lower alkoxy)phenyl) propionic acid or 2-amino-3-(4-halophenyl)propionic acid; Y is Phe, desamino-Phe, (lower alkanoyl)-Phe, p-haloPhe, Tyr, desamino-Tyr or (lower alkanoyl)-Tyr, or Y is the decapeptide radical W--Val--R.sup.7 --Ser--R.sup.8 --R.sup.9 --Thr--Glu--R.sup.10 --Ser--Phe wherein W is hydrogen or lower alkanoyl and R.sup.7 to R.sup.10 are designated amino acids residues, or Y is a fragment of the decapeptide radical wherein from one to nine of the amino acid residues (i.e. Val to Ser) may be deleted serially from the amino terminus of the decapeptide radical; and Z is hydroxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: February 1, 1990
    Date of Patent: December 10, 1991
    Assignee: Bio-Mega Inc.
    Inventors: Yvan Guindon, Pierre Lavallee, Sumanas Rakhit, Gregory P. Cosentino
  • Tetrahydrocarbazole 1-alkanoic acids and pharmaecutical compositions
    Patent number: 5021447
    Abstract: Tetrahydrocarbazole 1-alkanoic acids are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion and dysmenorrhea and as cytoprotective agents.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: June 4, 1991
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yvan Guindon, Christiane Yoakim, John W. Gillard, Yves Girard
  • Cyclohept(B)indolealkanoic acids, pharmaceutical compositions and use
    Patent number: 5017597
    Abstract: Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet, aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
    Type: Grant
    Filed: December 4, 1989
    Date of Patent: May 21, 1991
    Assignee: Merck Frosst Canada, Inc.
    Inventors: John W. Gillard, Yvan Guindon, Howard E. Morton, Yves Girard, Christiane Yoakim
  • Leukotriene antagonists
    Patent number: 5017583
    Abstract: Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.
    Type: Grant
    Filed: February 23, 1988
    Date of Patent: May 21, 1991
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Robert N. Young, Joshua Rokach, Haydn R. Williams, Masatoshi Kakushima, Yvan Guindon
  • Cyclohept[b]indolealkanoic acids, pharmaceutical compositions and use
    Patent number: 5017593
    Abstract: Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
    Type: Grant
    Filed: October 4, 1989
    Date of Patent: May 21, 1991
    Assignee: Merck Frosst, Canada, Inc.
    Inventors: John W. Gillard, Yvan Guindon, Howard E. Morton, Yves Girard, Christiane Yoakim
  • 4,7-benzofurandione derivatives
    Patent number: 4968821
    Abstract: 4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention.
    Type: Grant
    Filed: July 11, 1988
    Date of Patent: November 6, 1990
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Julian Adams, Yvan Guindon, Patrice C. Belanger, Michel L. Belley, Joshua Rokach
  • Tetrahydrocarbazole esters, pharmaceutical compositions and use
    Patent number: 4940719
    Abstract: Tetrahydrocarbazole esters are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion and dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
    Type: Grant
    Filed: September 28, 1987
    Date of Patent: July 10, 1990
    Assignee: Merck Frosst Canada, Inc.
    Inventors: John W. Gillard, Christiane Yoakim, Yvan Guindon, Yves Girard
  • Phenothiazone derivatives and analogs
    Patent number: 4939145
    Abstract: Phenothiazone derivatives and analogs thereof, pharmaceutical compositions and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.
    Type: Grant
    Filed: January 19, 1989
    Date of Patent: July 3, 1990
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Cheuk K. Lau, Joshua Rokach, Christiane Yoakim, Rejean Fortin, Yvan Guindon
  • Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
    Patent number: 4933351
    Abstract: Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit the mammalian 5-lipoxygenase enzyme, thus preventing the metabolism of arachidonic acid to the leukotrienes. These compounds are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.
    Type: Grant
    Filed: January 30, 1989
    Date of Patent: June 12, 1990
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Joseph G. Atkinson, Yvan Guindon, Cheuk K. Lau
  • 4,7-diacyloxybenzofuran derivatives
    Patent number: 4912131
    Abstract: 4,7-Diacyloxybenzofuran derivatives of Formula I, are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: March 27, 1990
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Julian Adams, Yvan Guindon
  • Cyclohept[b]indoleakanoic acids, pharmaceutical compositions and use
    Patent number: 4906654
    Abstract: Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
    Type: Grant
    Filed: June 27, 1988
    Date of Patent: March 6, 1990
    Assignee: Merck Frosst Canada, Inc.
    Inventors: John W. Gillard, Howard E. Morton, Yvan Guindon, Yves Girard, Christiane Yoakim
  • Benzo[a]phenothiazines and hydro-derivatives for inhibiting leukotriene biosynthesis
    Patent number: 4876246
    Abstract: Pharmaceutical compositions containing a compound of Formula I: ##STR1## wherein X is O, S, SO or SO.sub.2 and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be positioned anywhere on the structure, or a pharmaceutically-acceptable salt thereof and certain novel benzo[a]phenothiazines, which compositions and compounds are useful in treating allergic conditions, asthma, cardiovascular disorders, inflammation and pain and are useful as cytoprotective agents.
    Type: Grant
    Filed: April 20, 1988
    Date of Patent: October 24, 1989
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yvan Guindon, Yves Girard, Cheuk K. Lau, Rejean Fortin, Joshua Rokach, Christiane Yoakim
  • Pharmaceutical compositions of phenothiazone derivatives and analogs
    Patent number: 4859667
    Abstract: Phenothiazone derivatives and analogs thereof, pharmaceutical compositions and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.
    Type: Grant
    Filed: January 14, 1987
    Date of Patent: August 22, 1989
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Cheuk K. Lau, Christiane Yoakim, Joshua Rokach, Rejean Fortin, Yvan Guindon
  • Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein
    Patent number: 4855481
    Abstract: An intermediate compound of the formula ##STR1## wherein Y is chloro or bromo: Pr is a protecting group selected from benzoyl, acetyl, triphenylsilyl or t-butyldiphenylsilyl:R.sup.5 is C.sub.1-5 alkyl or benzyl; andR.sup.7 is C.sub.1-5 alkyl, benzyl, C.sub.2-5 alkoxyalkyl or C.sub.3-5 alkoxyalkoxyalkyl,useful for the preparation of certain HMG-CoA reductase inhibitors.
    Type: Grant
    Filed: April 4, 1988
    Date of Patent: August 8, 1989
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yvan Guindon, Christiane Yoakim, Howard E. Morton
  • Method of inhibiting mammalian leukotriene biosynthesis
    Patent number: 4845083
    Abstract: Phenothiazine derivatives and analogs thereof having the Formula I are useful as inhibitors of the biosynthesis of mammalian leukotrienes. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation, and are useful as cytoprotective agents.
    Type: Grant
    Filed: January 9, 1987
    Date of Patent: July 4, 1989
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Rejean Fortin, Cheuk K. Lau, Yvan Guindon, Joshua Rokach, Christiane Yoakim
  • Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
    Patent number: 4822803
    Abstract: Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit the mammalian 5-lipoxygenase enzyme, thus preventing the metabolism of arachidonic acid to the leukotrienes. These compounds are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.
    Type: Grant
    Filed: February 4, 1988
    Date of Patent: April 18, 1989
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Joseph G. Atkinson, Yvan Guindon, Cheuk K. Lau
  • Phenoxypropoxy halophenylacetic acids as leukotriene antagonists
    Patent number: 4820867
    Abstract: Compounds of the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic and anti-inflammatory agents.
    Type: Grant
    Filed: April 22, 1986
    Date of Patent: April 11, 1989
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Patrice Belanger, Rejean Fortin, Yvan Guindon, Christiane Yoakim, Joshua Rokach
  • Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use
    Patent number: 4808608
    Abstract: Tetrahydrocarbazole 1-alkanoic acids are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platlet aggregation, cerebral spasm, premature labor, spontaneous abortion and dysmenorrhea and as cytoprotective agents.
    Type: Grant
    Filed: July 21, 1987
    Date of Patent: February 28, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Yvan Guindon, Christiane Yoakim, John W. Gillard, Yves Girard
  • 4,7-diacetoxy-2-(4-methoxybenzyl)-3,5,6-trimethylbenzofuran
    Patent number: 4800228
    Abstract: 4,7-Diacyloxybenzofuran derivatives of Formula I, are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents.
    Type: Grant
    Filed: June 18, 1987
    Date of Patent: January 24, 1989
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Julian Adams, Yvan Guindon
  • 4,7-benzofurandione derivatives useful as inhibitors of leukotriene synthesis
    Patent number: 4778805
    Abstract: 4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention.
    Type: Grant
    Filed: June 18, 1987
    Date of Patent: October 18, 1988
    Assignee: Merck Frosst Canada
    Inventors: Julian Adams, Yvan Guindon, Patrice C. Belanger, Michel L. Belley, Joshua Rokach