Patents by Inventor Yves-Claude Nicolau

Yves-Claude Nicolau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN
    Publication number: 20100267674
    Abstract: The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
    Type: Application
    Filed: June 28, 2010
    Publication date: October 21, 2010
    Applicants: NORMOXYS, INC., UNIVERSITE DE STRASBOURG
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
  • Inositol pyrophosphates, and methods of use thereof
    Publication number: 20100256094
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
    Type: Application
    Filed: December 23, 2009
    Publication date: October 7, 2010
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina Fylaktakidou, Ruth Greferath
  • Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin
    Patent number: 7745423
    Abstract: The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: June 29, 2010
    Assignees: NormOxys, Inc, Universite de Strasbourg
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
  • CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN
    Publication number: 20100029594
    Abstract: The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
    Type: Application
    Filed: July 21, 2009
    Publication date: February 4, 2010
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
  • CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN
    Publication number: 20100029593
    Abstract: The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
    Type: Application
    Filed: September 4, 2009
    Publication date: February 4, 2010
    Inventors: YVES CLAUDE NICOLAU, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
  • Inositol pyrophosphates, and methods of use thereof
    Patent number: 7648970
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphosphate (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: January 19, 2010
    Assignee: Normoxys, Inc.
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina Fylaktakidou, Ruth Greferath
  • Inositol pyrophosphates, and methods of use thereof
    Patent number: 7618954
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: November 17, 2009
    Assignees: NormOxys, Inc., Universite de Strasbourg
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina Fylaktakidou, Ruth Greferath
  • METHODS AND COMPOSITIONS FOR DISEASES ASSOCIATED WITH AMYLOIDOSIS
    Publication number: 20090202627
    Abstract: The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods and compositions comprising therapeutic vaccines, antisera and molecular constructs, comprising expression vectors and fusion proteins encoded therein.
    Type: Application
    Filed: April 15, 2009
    Publication date: August 13, 2009
    Applicants: AVENTIS PHARMA S.A., UNIVERSITE LOUIS PASTEUR
    Inventor: Yves Claude NICOLAU
  • THERAPEUTIC VACCINE TARGETED AGAINST P-GLYCOPROTEIN 170 FOR INHIBITING MULTIDRUG RESISTANCE IN THE TREATMENT OF CANCERS
    Publication number: 20080026995
    Abstract: The invention relates to conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein. The peptide may be covalently attached to spacers which may be polyethyleneglycol (PEG), polyglycine, polylysine or any polymer chain suitable for human use and is coupled at its free end to a phospholipids, e.g., phosphatidylethanolamine or any other chemically suitable phospholipid.
    Type: Application
    Filed: October 18, 2006
    Publication date: January 31, 2008
    Applicant: AC IMMUNE SA
    Inventors: Pierre-Francois Tosi, Claudie Madoulet, Yves-Claude Nicolau, David T. Hickman
  • Inositol pyrophosphates, and methods of use thereof
    Patent number: 7084115
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: August 1, 2006
    Assignee: OxyPlus, Inc.
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina Fylaktakidou, Ruth Greferath
  • Methods and compositions for diseases associated with amyloidosis
    Patent number: 7067133
    Abstract: The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods and compositions comprising therapeutic vaccines, antisera and molecular constructs, comprising expression vectors and fusion proteins encoded therein.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: June 27, 2006
    Assignees: Aventis Pharma S.A., Université Louis Pasteur
    Inventor: Yves Claude Nicolau
  • Methods and compositions of monoclonal antibodies specific for beta-amyloid proteins
    Patent number: 7060270
    Abstract: This invention provides methods and compositions for the detection, diagnosis and treatment of amyloid-associated diseases, in particular, diseases comprising deposition of amyloid assemblies, fibrils, filaments, tangles, or plaques. A preferred composition comprises monoclonal antibodies that specifically bind amyloid proteins, peptides or fragments and change the conformation.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: June 13, 2006
    Assignee: Diagenics International Corporation
    Inventors: Yves Claude Nicolau, Ruth Greferath
  • Methods and compositions comprising supramolecular antigenic constructs and antibodies elicited against them
    Publication number: 20040242845
    Abstract: The present invention comprises novel compositions and methods for eliciting high immune responses, of great specifity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, P170 glycoprotein. The novel compositions of the invention comprise supramolecuIlar antigenic constructs generally comprising a peptide sequence, covalently attached to pegylated lysine resulting in modified and enhanced peptide presentation.
    Type: Application
    Filed: February 20, 2004
    Publication date: December 2, 2004
    Inventors: Yves Claude Nicolau, Ruth Greferath
  • Sterols bearing pendant allosteric effectors of hemoglobin, and uses thereof
    Publication number: 20040072801
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering a broad range of anionic molecules to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering a ligand for the allosteric site of hemoglobin to the cytoplasm of the red blood cells.
    Type: Application
    Filed: June 11, 2003
    Publication date: April 15, 2004
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina Fylaktakidou, Stephane P. Vincent
  • Inositol pyrophosphates, and methods of use thereof
    Publication number: 20040014642
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
    Type: Application
    Filed: April 29, 2003
    Publication date: January 22, 2004
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina Fylaktakidou, Ruth Greferath
  • Ammonium salts of inositol hexaphosphate, and uses thereof
    Patent number: 6610702
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering inositol hexaphospahte (IHP) to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: August 26, 2003
    Assignee: GMP Oxycell, Inc.
    Inventors: Jean-Marie Lehn, Yves Claude Nicolau, Stephane P. Vincent
  • Methods and compositions of monoclonal antibodies specific for beta-amyloid proteins
    Publication number: 20030108551
    Abstract: This invention provides methods and compositions for the detection, diagnosis and treatment of amyloid-associated diseases, in particular, diseases comprising deposition of amyloid assemblies, fibrils, filaments, tangles, or plaques. A preferred composition comprises monoclonal antibodies that specifically bind amyloid proteins, peptides or fragments and change the conformation.
    Type: Application
    Filed: November 4, 2002
    Publication date: June 12, 2003
    Inventors: Yves Claude Nicolau, Ruth Greferath
  • Ammonium salts of inositol hexaphosphate, and uses thereof
    Publication number: 20020173494
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering inositol hexaphospahte (IHP) to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
    Type: Application
    Filed: August 1, 2001
    Publication date: November 21, 2002
    Inventors: Jean-Marie Lehn, Yves Claude Nicolau, Stephane P. Vincent
  • Methods and compositions for diseases associated with amyloidosis
    Publication number: 20020156036
    Abstract: The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods and compositions comprising therapeutic vaccines, antisera and molecular constructs, comprising expression vectors and fusion proteins encoded therein.
    Type: Application
    Filed: September 6, 2001
    Publication date: October 24, 2002
    Inventor: Yves Claude Nicolau
  • Ammonium salts of hemoglobin allosteric effectors, and uses thereof
    Publication number: 20020142995
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering a broad range of anionic molecules to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering a ligand for the allosteric site of hemoglobin to the cytoplasm of the red blood cells.
    Type: Application
    Filed: August 1, 2001
    Publication date: October 3, 2002
    Inventors: Yves Claude Nicolau, Jaime E. Lazarte, Dennis R. Alford