Patents by Inventor Yves Girard

Yves Girard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis
    Patent number: 5132319
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: July 21, 1992
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yves Girard, Pierre Hamel, Daniel Delorme, Rejean Fortin
  • Pyrrolo[1,2-a]indole hydroxylamine derivatives as inhibitors of leukotriene biosynthesis
    Patent number: 5128364
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: July 7, 1992
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yves Girard, Pierre Hamel
  • Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
    Patent number: 5093356
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
    Type: Grant
    Filed: January 16, 1990
    Date of Patent: March 3, 1992
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yves Girard, Pierre Hamel, Daniel Delorme
  • Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
    Patent number: 5036067
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
    Type: Grant
    Filed: March 14, 1990
    Date of Patent: July 30, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Yves Girard, Pierre Hamel, Daniel Delorme
  • Tetrahydrocarbazole 1-alkanoic acids and pharmaecutical compositions
    Patent number: 5021447
    Abstract: Tetrahydrocarbazole 1-alkanoic acids are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion and dysmenorrhea and as cytoprotective agents.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: June 4, 1991
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yvan Guindon, Christiane Yoakim, John W. Gillard, Yves Girard
  • Cyclohept(B)indolealkanoic acids, pharmaceutical compositions and use
    Patent number: 5017597
    Abstract: Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet, aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
    Type: Grant
    Filed: December 4, 1989
    Date of Patent: May 21, 1991
    Assignee: Merck Frosst Canada, Inc.
    Inventors: John W. Gillard, Yvan Guindon, Howard E. Morton, Yves Girard, Christiane Yoakim
  • Cyclohept[b]indolealkanoic acids, pharmaceutical compositions and use
    Patent number: 5017593
    Abstract: Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
    Type: Grant
    Filed: October 4, 1989
    Date of Patent: May 21, 1991
    Assignee: Merck Frosst, Canada, Inc.
    Inventors: John W. Gillard, Yvan Guindon, Howard E. Morton, Yves Girard, Christiane Yoakim
  • Tetrahydrocarbazole esters, pharmaceutical compositions and use
    Patent number: 4940719
    Abstract: Tetrahydrocarbazole esters are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion and dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
    Type: Grant
    Filed: September 28, 1987
    Date of Patent: July 10, 1990
    Assignee: Merck Frosst Canada, Inc.
    Inventors: John W. Gillard, Christiane Yoakim, Yvan Guindon, Yves Girard
  • Cyclohept[b]indoleakanoic acids, pharmaceutical compositions and use
    Patent number: 4906654
    Abstract: Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
    Type: Grant
    Filed: June 27, 1988
    Date of Patent: March 6, 1990
    Assignee: Merck Frosst Canada, Inc.
    Inventors: John W. Gillard, Howard E. Morton, Yvan Guindon, Yves Girard, Christiane Yoakim
  • Benzo[a]phenothiazines and hydro-derivatives for inhibiting leukotriene biosynthesis
    Patent number: 4876246
    Abstract: Pharmaceutical compositions containing a compound of Formula I: ##STR1## wherein X is O, S, SO or SO.sub.2 and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be positioned anywhere on the structure, or a pharmaceutically-acceptable salt thereof and certain novel benzo[a]phenothiazines, which compositions and compounds are useful in treating allergic conditions, asthma, cardiovascular disorders, inflammation and pain and are useful as cytoprotective agents.
    Type: Grant
    Filed: April 20, 1988
    Date of Patent: October 24, 1989
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yvan Guindon, Yves Girard, Cheuk K. Lau, Rejean Fortin, Joshua Rokach, Christiane Yoakim
  • Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use
    Patent number: 4808608
    Abstract: Tetrahydrocarbazole 1-alkanoic acids are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platlet aggregation, cerebral spasm, premature labor, spontaneous abortion and dysmenorrhea and as cytoprotective agents.
    Type: Grant
    Filed: July 21, 1987
    Date of Patent: February 28, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Yvan Guindon, Christiane Yoakim, John W. Gillard, Yves Girard
  • Cyclohept[b]indolealkanoic acids, pharmaceutical compositions and use
    Patent number: 4775680
    Abstract: Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
    Type: Grant
    Filed: July 21, 1987
    Date of Patent: October 4, 1988
    Assignee: Merck & Co., Inc.
    Inventors: John W. Gillard, Yvan Guindon, Howard E. Morton, Yves Girard
  • Leukotriene antagonists
    Patent number: 4761425
    Abstract: Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory agents, and cytoprotective agents.
    Type: Grant
    Filed: December 24, 1984
    Date of Patent: August 2, 1988
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yves Girard, Joshua Rokach
  • Anti-allergic and anti-thromboembolic 6H-dibenz-[b,e][1,4]-oxathiepin derivatives, compositions, and method of use therefor
    Patent number: 4663307
    Abstract: Novel 6H-dibenz[b,e][1,4]oxathiepin derivatives of the Formulae I and IA are employed in the treatment and control of allergic conditions such as allergic asthma.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: May 5, 1987
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yves Girard, Joshua Rokach, Pierre Hamel
  • Benzo[A]phenothiazines and hydro-derivatives
    Patent number: 4611056
    Abstract: Pharmaceutical compositions containing a compound of Formula I: ##STR1## wherein X is O, S, SO or SO.sub.2 and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be positioned anywhere on the structure, or a pharmaceutically-acceptable salt thereof and certain novel benzo[a]phenothiazines, which compositions and compounds are useful in treating allergic conditions, asthma, cardiovascular disorders, inflammation and pain and are useful as cytoprotective agents.
    Type: Grant
    Filed: March 28, 1985
    Date of Patent: September 9, 1986
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yvan Guindon, Yves Girard, Cheuk K. Lau, Rejean Fortin, Joshua Rokach, Christiane Yoakim
  • (3-Aralkylamino-2-or-propoxy) heterocyclic compounds
    Patent number: 4331679
    Abstract: Compounds of the formula Het-O-CH.sub.2 -CHOR-CH.sub.2 -NH-aralkyl where Het is ##STR1## are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: May 25, 1982
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventor: Yves Girard
  • Substituted phenyl alanine antihypertensive agents
    Patent number: 4271187
    Abstract: A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
    Type: Grant
    Filed: September 18, 1979
    Date of Patent: June 2, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, Clarence S. Rooney, Yves Girard, Edward L. Engelhardt
  • Antihypertensive N-heterocyclicalanines
    Patent number: 4206216
    Abstract: A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: June 3, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, Clarence S. Rooney, Yves Girard, Edward L. Engelhardt
  • Indolyl amino acids useful as antihypertensive agents
    Patent number: 4153715
    Abstract: A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
    Type: Grant
    Filed: August 16, 1977
    Date of Patent: May 8, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, Clarence S. Rooney, Yves Girard, Edward L. Engelhardt
  • Amino acids and esters thereof useful as antihypertensive agents
    Patent number: 4065572
    Abstract: A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
    Type: Grant
    Filed: February 13, 1976
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Joseph George Atkinson, Clarence Stanley Rooney, Yves Girard, Edward L. Engelhardt