Abstract: The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.

Abstract: A method for the measurement of performance parameters of an asynchronous transfer mode transmission network having an asynchronous transfer mode channel, the method including: generating identifiable measurement cells and inserting the identifiable measurement cells into an asynchronous incident flow transmitted by the asynchronous transfer mode channel; receiving an asynchronous flow of cells from the channel, counting a total number of cells received in the asynchronous flow, detecting the identifiable measurement cells among the asynchronous flow and counting a total number of identifiable measurement cells received in the asynchronous flow, comparing a content of each individual identifiable measurement cell with an expected content for that individual identifiable measurement cell so as to detect transmission errors, generating and memorizing a counting information element upon each reception of a given number of cells in the asynchronous flow, the counting information element comprising the total numbe