Abstract: The present disclosure provides engineered bacterial cells comprising a heterologous gene encoding a propionate catabolism enzyme. In another aspect, the engineered bacterial cells further comprise at least one heterologous gene encoding a transporter of propionate or a kill switch. The disclosure further provides pharmaceutical compositions comprising the engineered bacteria, and methods for treating disorders involving the catabolism of propionate, such as Propionic Acidemia and Methylmalonic Acidemia, using the pharmaceutical compositions.

Abstract: Genetically programmed microorganisms, such as bacteria, pharmaceutical compositions thereof, and methods of modulating and treating a disease and/or disorder are disclosed.

Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.

Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.

Abstract: The device combines ballast blocks (3) that can be stacked onto a base frame of the crane, and a gripper (2) for handling these blocks, the gripper being designed to be connected, during use, to a handling means. This device comprises means of nonpermanent connection, by hooking, between the gripper (2) and a ballast block (3) and means (34, 37, 38) for centering the stacked ballast blocks (3) relative to one another. The aforementioned connection means are constituted by two opposed gripping hooks (15, 16) mounted pivotably at the ends of a lifting beam (4) of the gripper (2) and interacting with transverse pins (35) of a block (3). The rear part of each hook (15, 16) is attached to a sling (27, 28), and a lock (21, 22) is assigned to it. The invention applies in particular to the ballasting of tower cranes.

Abstract: The device combines ballast blocks (3) that can be stacked onto a base frame of the crane, and a gripper (2) for handling these blocks, the gripper being designed to be connected, during use, to a handling means. This device comprises means of nonpermanent connection, by hooking, between the gripper (2) and a ballast block (3) and means (34, 37, 38) for centering the stacked ballast blocks (3) relative to one another. The aforementioned connection means are constituted by two opposed gripping hooks (15, 16) mounted pivotably at the ends of a lifting beam (4) of the gripper (2) and interacting with transverse pins (35) of a block (3). The rear part of each hook (15, 16) is attached to a sling (27, 28), and a lock (21, 22) is assigned to it. The invention applies in particular to the ballasting of tower cranes.

Abstract: The invention relates to the mounting of the revolving part of a tower crane, at the top of the mast. A first assembly, formed by the counterjib (8), its tie rod (19) and a rear part (22) of the jib bearer (5), made in two separable parts, is pre-built on the ground, then lifted up and assembled by pinning (at 18) on the revolving pivot or the mast-cab (10) and is held temporarily in place by retaining link rods (48). Another assembly, formed by the jib (6), its tie rods (13, 14) and the front part (21) of the jib bearer, is also pre-built on the ground, then lifted up and assembled by pinning (at 77) on the revolving pivot or the mast-cab (10). The respective tops (28, 47) of the front part (21) and of the rear part (22) of the jib bearer (5) are then joined together by temporary pinning along an axis (78), followed by definitive pinning along an axis (79).

Abstract: The device provides dismantlable assembly between the top of the upper element of the mast of a tower crane and the fixed pivot which serves to support and to orientate the rotating upper part of the crane comprising the jib. Fishplates are fixed at the four corners of the pivot, of square horizontal section, in the direction of the diagonal, the fishplates lying within the permissible size for transporting this pivot. Other fishplates are fixed to the four corners of the top of the mast element, on the inside of the uprights of this element. The fishplates have holes which come into alignment, and through which removable connecting pins are fitted.

Abstract: A tail piece for a projectile includes at least three fins connected to either the projectile itself or a bracket connected to the projectile. Each fin is linked to the projectile/bracket by at least one fastening foot that cooperates with at least one recess of the projectile/bracket.

Abstract: There is disclosed a kinetic energy type projectile having an armor piercing head which is intended to penetrate multi-shell targets, and even sharply angled targets. The piercing head is provided with favorably discriminated shearing regions which are axially spaced apart by distances corresponding to the thicknesses of the shells which are to be pierced by the piercing head. The shearing regions are provided by external or internal localized transverse weakenings e.g. grooves, or heat treatments by electronic bombardment, applied to the external surface of the piercing head and/or in a central bore in the piercing head. Additionally, the localized weakenings may be provided by bound collars on the piercing head.The shearing regions are progressively stronger in a direction from the front of the piercing head so that they will shear consecutively as the head pierces successive shells of a multi-shell target.