Abstract: The present invention presents compounds that inhibit phosphodiesterase 4 having Formula (I). The present invention also provides methods of using the compounds of Formula (I) to prevent or treat asthma, atopic dermatitis, rheumatoid arthritis, inflammatory bowel disorders, pulmonary hypertension, liver injury, bone loss, septic shock, or multiple sclerosis, and to pharmaceutical compositions that contain the compounds of Formula (I).

Abstract: Diazepinoindoles of formula (I), ##STR1## wherein A is mono- to trisubstituted aryl or heteroaryl, and B is an --OR.sub.1 or --NR.sub.2 R.sub.3 group where R.sub.1, R.sub.2 and R.sub.3 are particularly hydrogen, and racemic forms, enantiomers and pharmaceutically acceptable salts thereof, as phosphodiesterase IV inhibitors, are disclosed.

Abstract: The invention relates to diazepinoindoles of formula: ##STR1## in which R is hydrogen, lower alkyl or lower alkoxy; A is aryl or nitrogen-containing heteroaryl, each of which is optionally substituted by from one to three groups of halogen, lower alkyl, haloalkyl, lower alkoxy and acetamido, or their racemic forms, isomers or pharmaceutically acceptable salts, wherein for the racemic forms of the (S) configuration, A is not phenyl, haloalkyl, or 2-indolyl when R is hydrogen, and for the racemic forms of the (R) configuration, A is not 2-indolyl when R is hydrogen. Also, the invention relates to a method for inhibiting cyclic nucleotide phosphodiesterase activity by administering these compounds to a subject in an amount which is therapeutically effective to inhibit cyclic nucleotide phosphodiesterase activity.

Abstract: A device for trapping migrating bodies in nuclear power station steam generators or boilers is provided to prevent them from jamming between the generator tubes. The device, in the form of a grating or grid, is placed above a horizontal plate to which are fixed the upper ends of the pipes containing cyclone separators. It defines passages, whose largest dimensions are smaller than the minimum distance separating the tubes.

Abstract: The secondary water supply for a steam generator is provided by a toroidal or semitoroidal collector (38) placed in the bottom of the annular recirculation space (32) of the generator, in a larger diameter part (36) of the outer envelope. The collector (38) has holes (40) ensuring a vertical mean flow of the secondary water into the annular space (32). The cross-section of the holes is chosen in such a way as to trap in the collector the migrating bodies or members from the secondary water circuit and which could damage the steam generator tubes. At least one access orifice makes it possible to extract these migrating bodies from the collector during maintenance operations.

Abstract: In a steam generator or boiler used in a nuclear reactor, the secondary water is supplied via at least one pipe (48) issuing directly into the bottom of an annular recirculation space (32) formed between the outer envelope (10) and an inner envelope (26) surrounding inverted U-tubes (24), on the side of the cold branches of the tubes. A perforated collar or flange (56) placed in the annular space (32), above the pipe (48), produces a pressure drop or flow limitation preventing the rise of the feed water and controls the circumferential distribution of the recirculation water, which drops from the separators (28).

Abstract: In a preheating steam generator, the feed water is distributed in a feed space (34) by inverted J-shaped tubes (50), so as to mix with the recirculation water passing out of the water-steam separators, which ensures the preheating of said feed water. In order to prevent the latter rising again above the upper edge (30a) of skirt (30) externally defining the space (34), use is made of one or more of the four procedures consisting of partly obstructing by a plate (52) the top of space (34), downwardly extending tube (50), increasing the diameter in the vicinity of their end and upwardly extending skirt (30).

Abstract: Cold water introduced with a low flow rate into a duct filled with hot water normally circulates in the bottom thereof and accumulates at its end. It is discharged only at the end of the distributor where its pressure is highest. The immiscible hot water is located elsewhere and high thermal stresses appear on the distributor at the interface between two layers. This problem is solved by providing the distributing tubes (2) or the actual duct (1) with cuts (6 and 9) in particular favoring the upstream flow.

Abstract: A steam generator has a pressure vessel containing a stack of exchange tubes and a feedwater header of ring shape connected to a feed water intake pipe passing through the wall of the vessel. A horitzontal section of the pipe contains at least one deflector comprising an axial hub and several helical blades connecting the hub to the wall of the pipe. The blades have a length which represents at least half a winding pitch if the deflector is to counteract thermal stratification only, at least 1.5 winding pitch if for avoiding pressure surges.