Patents by Inventor Yves Robert Alain Pascal

Yves Robert Alain Pascal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apovincaldehyde
    Patent number: 4001251
    Abstract: Vincamine and/or its stereoisomers, a known drug, is made from vincaminol and/or its stereoisomers by successive conversion of the latter into apovincaldehyde, apovincamine, and 16-methoxycarbonyl-eburnane, followed by conversion of the last into vincamine either directly by introduction of a 16-hydroxyl group or by hydrolysis, introduction of a 16-hydroxyl group, and re-esterification.
    Type: Grant
    Filed: June 5, 1975
    Date of Patent: January 4, 1977
    Assignee: Synthelabo
    Inventors: Henry Najer, Yves Robert Alain Pascal
  • Vincaminic acid esters
    Patent number: 3987177
    Abstract: The invention provides vincaminic acid esters of formula ##SPC1##Wherein R.sub.1 is hydrogen or hydroxy, R.sub.2 is hydrogen or R.sub.1 and R.sub.2 form an additional bond between the two carbon atoms to which they are attached, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen or methyl, and their salts. The esters are useful in treatment of cardiac-circulatory, cerebal-vascular or respiratory insufficiency.
    Type: Grant
    Filed: June 20, 1975
    Date of Patent: October 19, 1976
    Assignee: Synthelabo
    Inventors: Don Pierre Rene Lucien Giudicelli, Henry Najer, Yves Robert Alain Pascal, Patrick Andre Louis Lardenois
  • Vinvamine series cycloalkyl-alkyl esters
    Patent number: 3966745
    Abstract: Compounds of the general formula ##SPC1##Wherein R.sub.1 is H or OH and R.sub.2 is H or R.sub.1 and R.sub.2 together represent an additional double bond between the two carbon atoms to which they are attached and m and n are integers of 1 to 5 and 2 to 7 respectively; and pharmaceutically acceptable acid addition salts thereof. The compounds are useful for the treatment of vascular disorders in mammals.
    Type: Grant
    Filed: May 6, 1974
    Date of Patent: June 29, 1976
    Assignee: Synthelabo
    Inventors: Don Pierre Rene Lucien Giudicelli, Henry Najer, Bogdan Iliesco-Branceni, Yves Robert Alain Pascal
  • Process for the preparation of cis-vincamine
    Patent number: 3950345
    Abstract: A process is provided for the preparation of cis-vincamine by oxidising trans-vincamine with tertiary butyl hypochlorite to obtain dehydrovincamine chloride, reducing the dehydrovincamine chloride with a metal in an aqeous acidic medium and neutralising the product, and separating cis-vincamine from the resulting mixture of cis- and trans-vincamines. Cis-vincamine is useful for the treatment of circulatory disorders.
    Type: Grant
    Filed: February 21, 1975
    Date of Patent: April 13, 1976
    Assignee: Synthelabo
    Inventors: Henry Najer, Yves Robert Alain Pascal, Jean Pierre Gaston Lefevre