Abstract: Agents that inhibit the dimerization of a prototypic galectin such as galectin-7 are described. These agents, for example antibodies and peptides, bind to a domain corresponding to residues 13-25, 86-108 and/or 129-135 of human galectin-7. The use of such agents to inhibit a biological, physiological and/or pathological process that involves prototypic galectin dimerization, for example for, the inhibition of galectin-7-mediated apoptosis and the treatment of galectin-7-expressing cancers, is also described.

Abstract: Monovalent antibodies such as nanobodies that are specific for galectin-7 are described. These monovalent antibodies are able to interfere with the dimerization of galectin-7, and thus may be used for the treatment of diseases associated with dysregulated galectin-7 expression and/or activity, such as certain types of cancers as well as eye diseases or conditions associated with pathological neovascularization or angiogenesis.

Abstract: Agents that inhibit the dimerizaton of a prototypic galectin such as galectin-7 are described. These agents, for example antibodies and peptides, bind to a domain corresponding to residues 13-25, 86-108 and/or 129-135 of human galectin-7, The use of such agents to inhibit a biological, physiological and/or pathological process that involves prototypic galectin dirnerization, for example for, the inhibition of galectin-7-mediated apoptosis and the treatment of galectin-7-expressing cancers, is also described.

Abstract: Agents that inhibit the dimerization of a prototypic galectin such as galectin-7 are described. These agents, for example antibodies and peptides, bind to a domain corresponding to residues 13-25, 86-108 and/or 129-135 of human galectin-7. The use of such agents to inhibit a biological, physiological and/or pathological process that involves prototypic galectin dimerization, for example for the inhibition of galectin-7-mediated apoptosis and the treatment of galectin-7-expressing cancers, is also described.

Abstract: Agents that inhibit the dimerization of a prototypic galectin such as galectin-7 are described. These agents, for example antibodies and peptides, bind to a domain corresponding to residues 13-25, 86-108 and/or 129-135 of human galectin-7. The use of such agents to inhibit a biological, physiological and/or pathological process that involves prototypic galectin dimerization, for example for the inhibition of galectin-7-mediated apoptosis and the treatment of galectin-7-expressing cancers, is also described.

Abstract: A segmented track made of a plurality of elastomeric track segments is disclosed. Each track segment is made of reinforced elastomeric material and is provided, at each end thereof, with a joint element adapted to be connected to the joint element of adjacent track segments. Each track segment generally comprises alternating series of substantially rigid sections and substantially flexible sections. The joint elements of the track segments are substantially located within rigid sections located at the extremities of the track segments. The segment track also comprises inner and outer plates configured to secure the joint elements of adjacent track segments together.

Abstract: Methods, kits and systems for the diagnosis, prognosis and monitoring of ovarian cancer and rectal cancer are described. The methods, kits and systems are based on the detection of the lectin Galectin-7 in samples obtained from subjects.

Abstract: A segmented track made of a plurality of elastomeric track segments is disclosed. Each track segment is made of reinforced elastomeric material and is provided, at each end thereof, with a joint element adapted to be connected to the joint element of adjacent track segments. Each track segment generally comprises alternating series of substantially rigid sections and substantially flexible sections. The joint elements of the track segments are substantially located within rigid sections located at the extremities of the track segments. The segment track also comprises inner and outer plates configured to secure the joint elements of adjacent track segments together.

Abstract: A traction band substantially made from elastomeric material is disclosed. The traction band comprises a main band body divided into a plurality of sections connected together along laterally extending pitch lines. The band body has an interior wheel-engaging surface, adapted to cooperate with the various wheels of a track system, and an exterior ground-engaging surface adapted to engage the ground. The wheel-engaging surface comprises one or more rows of longitudinally spaced-apart drive lugs and/or guide lugs typically disposed on each of the band sections. The ground-engaging surface comprises traction lugs extending longitudinally across more than one band section, these traction lugs comprising laterally extending bending regions where the traction lugs are thinner. These bending regions are substantially aligned with regions on the interior surface which are devoid of drive lugs and guide lugs.

Abstract: A traction band substantially made from elastomeric material is disclosed. The traction band comprises a main band body divided into a plurality of sections connected together along laterally extending pitch lines. The band body has an interior wheel-engaging surface, adapted to cooperate with the various wheels of a track system, and an exterior ground-engaging surface adapted to engage the ground. The wheel-engaging surface comprises one or more rows of longitudinally spaced-apart drive lugs and/or guide lugs typically disposed on each of the band sections. The ground-engaging surface comprises traction lugs extending longitudinally across more than one band section, these traction lugs comprising laterally extending bending regions where the traction lugs are thinner. These bending regions are substantially aligned with regions on the interior surface which are devoid of drive lugs and guide lugs.

Abstract: This invention relates to a traction band for use with a snowmobile or the like and more particularly, to a traction band of reduced weight but as efficient as a regular traction band. The improved traction band comprises a longitudinal flexible body having a width defined by two side surfaces, and a series of reinforcing rods which do not extend across the full width. The rods are embedded within the body in an alternating fashion from one of the side surfaces with predetermined intervals in the longitudinal direction of the same.

Abstract: The invention relates to an improved traction band for use on a tracked vehicle and more particularly, on a snowmobile. The traction band is made of rubber and comprises a central portion and two opposite lateral portions. Each lateral portion is separated from the central portion by a row of holes defining clip areas. The central portion of the traction band further comprises a series of openings. These openings reduce the noise generated by the traction band when the vehicle is operated.

Abstract: This invention relates to an endless traction band that is used to propel band laying vehicles [i.e., vehicles which use endless traction bands rather than tires to contact the terrain over which they are driven, e.g., tractors, tanks, bulldozers, etc.]. A novel sprocket wheel having a plurality of radially extending and offset teeth cooperates with an endless traction band having a plurality of holes. Longitudinally consecutive holes define either meshing areas or clip areas. The meshing areas are adapted to be engaged by the sprocket wheel and the clip areas are adapted to support clips.

Abstract: This invention relates to an endless traction band that is used to propel snowmobiles and more particularly, to an improved ground-engaging side of the traction band, which helps reduce the noise and vibration levels during the operation of the snowmobile. The various protruding lug configurations defines a predetermined number of different lug profiles, from which the sequence of profiles on the endless band are generated in such a way so that every sequence of profiles is different from one another.

Abstract: This invention relates to an endless traction band that is used to propel band laying vehicles [i.e., vehicles which use endless traction bands rather than tires to contact the terrain over which they are driven, e.g., tractors, tanks, bulldozers, etc.] and, more particularly, to an improved traction band design for use with snowmobiles. The traction band comprises multiple sets of openings some of which are adapted to be engaged by a novel sprocket wheel.

Abstract: The endless track is made of a reinforced rubber material with longitudinally spaced and transversely disposed stiffeners embedded in the rubber material. The body defines a central band portion and opposite lateral band portions that are located on the sides of the central band portion. The central band portion is delimited from the two lateral band portions by two corresponding suspension bearing portions, each defining a plurality of clipping sites that are adapted to receive a metallic clip. The track is characterized in that the clips that are mounted in an arrangement of mixed clip sequences on each suspension bearing portion. Each [[c lip]] clip sequence comprises one or more successive clipping sites with clips immediately followed by one or two successive clipping sites without a clip. This arrangement of mixed clip sequences lowers the overall noise level generated by the track while rotating. It also lowers the overall weight of the track and the manufacturing costs thereof.

Abstract: The endless track is made of a reinforced rubber material with longitudinally spaced and transversely disposed ridges or lugs. It is particularly well-adapted for recreational snowmobiles having a single track. The ground-engaging side of the track features a tread pattern that is repeated uniformly or not over the entire length of the track. The tread pattern comprises a plurality of projecting traction lugs each having an upper edge. The internal side of the track features a plurality of protuberances called drive lugs which engage in the sprockets. These sprockets are driven by the snowmobile engine and transmit its power to the endless track. The braking power is also transmitted by the sprockets to the track. It is characterized in that the drive lugs have a pitch distance half of the pitch distance of the tread pattern therefore doubling the number of lugs engaged in the sprocket. Such tracks reduce noise and rolling resistance.

Abstract: This invention relates to an endless traction band that is used to propel snowmobiles and more particularly, to an improved ground-engaging side of the traction band, which helps reduce the noise and vibration levels during the operation of the snowmobile. The various protruding lug configurations defines a predetermined number of different lug profiles, from which the sequence of profiles on the endless band are generated in such a way so that every sequence of profiles is different from one another.

Abstract: This invention relates to vehicles equipped with rubber tires used to drive over diverse types of terrain and, more particularly, to a tire track which consists in one or more rubber track segments, attached with a joint assembly and designed to accommodate any types of wheel diameter, thickness and ground surface, when installed on top of rubber tires. Each rubber track segment is made from a profiled outside layer and an inner layer comprising side guides to hold the track on the tire. Each segment is linked with the next one by a joint assembly using links and fastening means to ensure complete covering of the tires periphery.