Abstract: A spectroscopic autofocusing method and a system for such a method are disclosed. According to one embodiment, a spectroscopic autofocusing method includes applying a plurality of electrical signals to a shape changing lens of a spectroscopy system. The method includes emitting, by an optical source coupled to the spectroscopy system, one or more optical signals directed to a target. The method includes determining, by a detector, one or more power measurements of one or more returned optical signals corresponding to an illuminated area of the target. The method includes aggregating, from the detector, the one or more power measurements, wherein each power measurement corresponds to a respective electrical signal of the plurality of electrical signals applied to the shape changing lens. The method includes determining an optimized electrical signal corresponding to a maximum power measurement indicated by the one or more power measurements.