Patents by Inventor Yvonne J. Vos

Yvonne J. Vos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transformed industrial bacillus strains and methods for making and using them
    Patent number: 5624829
    Abstract: Novel methods and novel industrial unicellular microorganism strains, particularly industrial Bacillus strains, are provided for enhanced production of endogenous and exogenous polypeptides. Cloning vehicles containing the gene expressing the polypeptide of interest are introduced into a compatible host. Transformed hosts harboring the introduced vehicle in a stable way by integration of the vehicle into the host cells chromosome are selected. Efficient transfer of the vehicle containing the gene of interest is achieved with the resulting industrial strain transformants being effective, stable producers of the desired polypeptide product.
    Type: Grant
    Filed: December 21, 1992
    Date of Patent: April 29, 1997
    Assignee: Gist-Brocades, B.V.
    Inventors: Johan P. M. Sanders, Johannes A. van den Berg, Peter M. Andreoli, Yvonne J. Vos, Jan H. van Ee, Leo J. S. M. Mulleners
  • Expression and purification of human interleukin-3 and muteins thereof
    Patent number: 5304637
    Abstract: Methods are provided for improved production of hIL-3 either in glycosylated form from mammalian and yeast cells or in unglycosylated form from prokaryotes. Recombinantly produced human IL-3 is purified in a series of steps, initially employing hydrophobic interaction, followed by ion exchange chromatography and gel filtration.
    Type: Grant
    Filed: March 13, 1990
    Date of Patent: April 19, 1994
    Assignee: Gist-brocades N.V.
    Inventors: Lambertus C. J. Dorssers, Gerard Wagemaker, Yvonne J. Vos, Robert W. Van Leen, Maria L. N. Persoon
  • Molecular cloning and expression in industrial Bacillus species
    Patent number: 5238833
    Abstract: Novel methods and novel industrial unicellular microorganism strains, particularly industrial Bacillus strains, are provided for enhanced production of endogenous and exogenous polypeptides. Cloning vehicles containing the gene expressing the polypeptide of interest are introduced into a compatible host. Transformed hosts harboring the introduced vehicle in a stable way by integration of the vehicle into the host cells chromosome are selected Efficient transfer of the vehicle containing the gene of interest is achieved, with the resulting industrial strain transformants being effective, stable producers of the desired polypeptide product.
    Type: Grant
    Filed: May 13, 1991
    Date of Patent: August 24, 1993
    Assignee: Gist-brocades, NV
    Inventors: Johan P. M. Sanders, Johannes A. Van Den Berg, Peter M. Andreoli, Yvonne J. Vos, Jan H. Van EE, Leo J. S. M. Mulleners