Patents by Inventor Yvonne Kerwitz

Yvonne Kerwitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amphoteric liposomes
    Patent number: 9737484
    Abstract: A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: August 22, 2017
    Assignee: Marina Biotech, Inc.
    Inventors: Steffen Panzner, Yvonne Kerwitz, Una Rauchhaus, Silke Lutz, Gerold Endert
  • AMPHOTERIC LIPOSOMES
    Publication number: 20150231073
    Abstract: A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.
    Type: Application
    Filed: November 12, 2014
    Publication date: August 20, 2015
    Inventors: Steffen Panzner, Yvonne Kerwitz, Una Rauchhaus, Silke Lutz, Gerold Endert
  • Amphoteric liposomes
    Patent number: 9066867
    Abstract: A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: June 30, 2015
    Assignee: Marina Biotech, Inc.
    Inventors: Steffen Panzner, Yvonne Kerwitz, Una Rauchhaus, Silke Lutz, Gerold Endert
  • Amphoteric Liposome Formulation
    Publication number: 20150118291
    Abstract: The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer.
    Type: Application
    Filed: December 12, 2014
    Publication date: April 30, 2015
    Inventors: Neal Clifford Goodwin, Gerold Endert, Natalie Herzog, Yvonne Kerwitz, Steffen Panzner, Wendi Rodrigueza
  • Amphoteric Liposome Formulation
    Publication number: 20130323298
    Abstract: The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer.
    Type: Application
    Filed: January 28, 2013
    Publication date: December 5, 2013
    Applicants: Novosom AG, ProNAi Therapeutics, Inc.
    Inventors: Neal Clifford Goodwin, Gerold Endert, Natalie Herzog, Yvonne Kerwitz, Steffen Panzner, Wendi Rodrigueza
  • Amphoteric liposome formulation
    Patent number: 8367628
    Abstract: The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: February 5, 2013
    Assignees: ProNAi Therapeutics, Inc., Novosom AG
    Inventors: Neal Clifford Goodwin, Gerold Endert, Natalie Herzog, Yvonne Kerwitz, Steffen Panzner, Wendi Rodrigueza
  • Serum-stable amphoteric liposomes
    Patent number: 8236770
    Abstract: The invention relates to amphoteric liposomal formulations which are provided with great serum stability and are suitable for the intracellular delivery of oligonucleotides.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: August 7, 2012
    Assignee: Marina Biotech, Inc.
    Inventors: Gerold Endert, Yvonne Kerwitz, Monika Fellermeier
  • Amphoteric liposomes
    Publication number: 20110076322
    Abstract: A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.
    Type: Application
    Filed: September 9, 2010
    Publication date: March 31, 2011
    Inventors: Steffen Panzner, Yvonne Kerwitz, Una Rauchhaus, Silke Lutz, Gerold Endert
  • Amphoteric Liposome Formulation
    Publication number: 20090220584
    Abstract: The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer.
    Type: Application
    Filed: December 1, 2006
    Publication date: September 3, 2009
    Inventors: Neal Clifford Goodwin, Gerold Endert, Natalie Herzog, Yvonne Kerwitz, Steffen Panzner, Wendi Rodrigueza
  • Serum-Stable Amphoteric Liposomes
    Publication number: 20080311181
    Abstract: The invention relates to amphoteric liposomal formulations which are provided with great serum stability and are suitable for the intracellular delivery of oligonucleotides.
    Type: Application
    Filed: March 29, 2005
    Publication date: December 18, 2008
    Inventors: Gerold Endert, Yvonne Kerwitz, Monika Fellermeier
  • Amphoteric liposomes
    Publication number: 20070104775
    Abstract: A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.
    Type: Application
    Filed: September 15, 2006
    Publication date: May 10, 2007
    Inventors: Steffen Panzner, Yvonne Kerwitz, Una Rauchhaus, Silke Lutz, Gerold Endert