Patents by Inventor Yvonne Lang

Yvonne Lang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmacologic method of lowering cholesterol production
    Patent number: 9110051
    Abstract: The present invention provides a screening method for identifying test agents that modulate cell membrane cholesterol activity. The modulating activity of the test agents may be measured using lytic compounds, which cause cell lysis or increases in cell permeability in response to cell membrane cholesterol levels. The invention further provides therapeutic agents that are identified using the screening method. The therapeutic agents either increase or decrease the cell membrane cholesterol activity, cholesterol concentration and/or both in vivo and/or in vitro.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: August 18, 2015
    Assignees: The University of Chicago, Rush University Medical Center
    Inventors: Yvonne Lange, Theodore L. Steck
  • Hollow biodegradable nanospheres and nanoshells for delivery of therapeutic and/or imaging molecules
    Patent number: 8802150
    Abstract: A polymeric hollow nanoshell or nanosphere for release of an agent is described, wherein the hollow nanosphere comprises at least one biodegradable polymer, characterized in that the polymer is cross-linked. The biodegradable mono-disperse nanospheres described are suitable for use as carriers of biomolecules, therapeutic agents and/or imaging agents.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: August 12, 2014
    Assignee: National University of Ireland
    Inventors: Abhay Pandit, Gildas Rethore, Hemantkumar Naik, Yvonne Lang, David Finn
  • Hollow biodegradable nanospheres and nanoshells for delivery of therapeutic and/or imaging molecules
    Patent number: 8734848
    Abstract: A polymeric hollow nanoshell or nanosphere for release of an agent is described, wherein the hollow nanosphere comprises at least one biodegradable polymer, characterised in that the polymer is cross-linked. The biodegradable mono-disperse nanospheres described are suitable for use as carriers of biomolecules, therapeutic agents and/or imaging agents.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: May 27, 2014
    Assignee: National University of Ireland, Galway (NUIG)
    Inventors: Abhay Pandit, Gildas Rethore, Hemantkumar Naik, Yvonne Lang, David Finn
  • HOLLOW BIODEGRADABLE NANOSPHERES AND NANOSHELLS FOR DELIVERY OF THERAPEUTIC AND/OR IMAGING MOLECULES
    Publication number: 20140004251
    Abstract: A polymeric hollow nanoshell or nanosphere for release of an agent is described, wherein the hollow nanosphere comprises at least one biodegradable polymer, characterised in that the polymer is cross-linked. The biodegradable mono-disperse nanospheres described are suitable for use as carriers of biomolecules, therapeutic agents and/or imaging agents.
    Type: Application
    Filed: August 29, 2013
    Publication date: January 2, 2014
    Applicant: National University of Ireland, Galway (NUIG)
    Inventors: Abhay Pandit, Gildas Rethore, Hemantkumar Naik, Yvonne Lang, David Finn
  • PHARMACOLOGIC METHOD OF LOWERING CHOLESTEROL PRODUCTION
    Publication number: 20120322091
    Abstract: The present invention provides a screening method for identifying test agents that modulate cell membrane cholesterol activity. The modulating activity of the test agents may be measured using lytic compounds, which cause cell lysis or increases in cell permeability in response to cell membrane cholesterol levels. The invention further provides therapeutic agents that are identified using the screening method. The therapeutic agents either increase or decrease the cell membrane cholesterol activity, cholesterol concentration and/or both in vivo and/or in vitro.
    Type: Application
    Filed: August 24, 2012
    Publication date: December 20, 2012
    Inventors: Yvonne LANG, Theodore L. Steck
  • HOLLOW BIODEGRADABLE NANOSPHERES AND NANOSHELLS FOR DELIVERY OF THERAPEUTIC AND/OR IMAGING MOLECULES
    Publication number: 20110123456
    Abstract: A polymeric hollow nanoshell or nanosphere for release of an agent is described, wherein the hollow nanosphere comprises at least one biodegradable polymer, characterised in that the polymer is cross-linked. The biodegradable mono-disperse nanospheres described are suitable for use as carriers of biomolecules, therapeutic agents and/or imaging agents.
    Type: Application
    Filed: September 20, 2010
    Publication date: May 26, 2011
    Inventors: Abhay Pandit, Gildas Rethore, Hemantkumar Naik, Yvonne Lang, David Finn
  • Pharmacologic Method Of Lowering Cholesterol Production
    Publication number: 20070274917
    Abstract: The present invention provides a screening method for identifying test agents that modulate cell membrane cholesterol activity. The modulating activity of the test agents may be measured using lytic compounds, which cause cell lysis or increases in cell permeability in response to cell membrane cholesterol levels. The invention further provides therapeutic agents that are identified using the screening method. The therapeutic agents either increase or decrease the cell membrane cholesterol activity, cholesterol concentration and/or both in vivo and/or in vitro.
    Type: Application
    Filed: April 13, 2005
    Publication date: November 29, 2007
    Inventors: Yvonne Lange, Theodore Steck
  • Mammalian sterol synthesis as a target for chemotherapy against bacteria
    Publication number: 20030087430
    Abstract: The present invention discloses methods for treating, ameliorating, or preventing having an infection due to an intracellular vacuolar bacterium. The invention further exemplifies the use of mevinolin (lovastatin) in the treatment of intracellular vacuolar bacterial infections.
    Type: Application
    Filed: October 9, 2002
    Publication date: May 8, 2003
    Inventors: Drew Catron, Kasturi Haldar, Yvonne Lange