Patents by Inventor Yvonne M. Chen

Yvonne M. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-CD8 ANTIBODIES AND USES THEREOF
    Publication number: 20240018241
    Abstract: Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.
    Type: Application
    Filed: June 30, 2023
    Publication date: January 18, 2024
    Applicant: Genentech, Inc.
    Inventors: Yvonne M. CHEN, Eugene Yu-Chuan CHIANG, Jane Louise GROGAN, Simon-Peter WILLIAMS, Matthew Lawrence ALBERT
  • Anti-CD8 antibodies and uses thereof
    Patent number: 11739150
    Abstract: Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: August 29, 2023
    Assignee: Genentech, Inc.
    Inventors: Yvonne M. Chen, Eugene Yu-Chuan Chiang, Jane Louise Grogan, Simon-Peter Williams, Matthew Lawrence Albert
  • ANTI-CD8 ANTIBODIES AND USES THEREOF
    Publication number: 20200172620
    Abstract: Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.
    Type: Application
    Filed: February 11, 2020
    Publication date: June 4, 2020
    Applicant: Genentech, Inc.
    Inventors: Yvonne M. CHEN, Eugene Yu-Chuan CHIANG, Jane Louise GROGAN, Simon-Peter WILLIAMS, Matthew Lawrence ALBERT
  • ANTIBODY VARIANTS
    Publication number: 20190202902
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Application
    Filed: July 13, 2018
    Publication date: July 4, 2019
    Applicant: Genentech, Inc.
    Inventors: Yvonne M. Chen, Henry B. Lowman, Yves Muller
  • ANTIBODY VARIANTS
    Publication number: 20170096480
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Application
    Filed: December 20, 2016
    Publication date: April 6, 2017
    Applicant: Genentech, Inc.
    Inventors: Yvonne M. Chen, Henry B. Lowman, Yves Muller
  • Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling
    Patent number: 9555107
    Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: January 31, 2017
    Assignee: Genentech, Inc.
    Inventors: Yvonne M. Chen, Anan Chuntharapai, Dimitry Danilenko, Wenjun Ouyang, Susan Sa, Patricia Valdez, Terence Wong, Jianfeng Wu, Yan Zheng
  • ANTIBODY VARIANTS
    Publication number: 20150284458
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Application
    Filed: June 18, 2015
    Publication date: October 8, 2015
    Applicant: GENENTECH, INC.
    Inventors: Yvonne M. CHEN, Henry B. LOWMAN, Yves MULLER
  • Antibody variants
    Patent number: 8703133
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: April 22, 2014
    Assignee: Genentech, Inc.
    Inventors: Yvonne M. Chen, Henry B. Lowman, Yves Muller
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH CYTOKINE SIGNALING
    Publication number: 20130224146
    Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.
    Type: Application
    Filed: February 24, 2012
    Publication date: August 29, 2013
    Inventors: Yvonne M. Chen, Anan Chuntharapai, Dimitry Danilenko, Wenjun Ouyang, Susan Sa, Patricia Valdez, Terence Wong, Jianfeng Wu, Yan Zheng
  • ANTIBODY VARIANTS
    Publication number: 20110182895
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Application
    Filed: March 21, 2011
    Publication date: July 28, 2011
    Inventors: YVONNE M. CHEN, HENRY B. LOWMAN, YVES MULLER
  • COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH CYTOKINE SIGNALING
    Publication number: 20100316596
    Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.
    Type: Application
    Filed: April 13, 2010
    Publication date: December 16, 2010
    Inventors: Yvonne M. Chen, Anan Chuntharapai, Dimitry Danilenko, Wenjun Ouyang, Susan Sa, Patricia Valdez, Terence Wong, Jianfeng Wu, Yan Zheng
  • Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling
    Patent number: 7737259
    Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: June 15, 2010
    Assignee: Genentech, Inc.
    Inventors: Yvonne M. Chen, Anan Chuntharapai, Dimitry Danilenko, Wenjun Ouyang, Susan Sa, Patricia Valdez, Terence Wong, Jianfeng Wu, Yan Zheng
  • ANTIBODY VARIANTS
    Publication number: 20100047236
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Application
    Filed: March 11, 2009
    Publication date: February 25, 2010
    Inventors: Yvonne M. Chen, Henry B. Lowman, Yves Muller
  • ANTIBODY VARIANTS
    Publication number: 20090010925
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Application
    Filed: September 28, 2006
    Publication date: January 8, 2009
    Inventors: Yvonne M. Chen, Henry B. Lowman, Yves Muller
  • Antibody variants
    Publication number: 20040086502
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Application
    Filed: July 21, 2003
    Publication date: May 6, 2004
    Applicant: Genentech, Inc.
    Inventors: Yvonne M. Chen, Henry B. Lowman, Yves Muller
  • Antibody variants
    Patent number: 6632926
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Grant
    Filed: November 16, 1999
    Date of Patent: October 14, 2003
    Assignee: Genentech, Inc.
    Inventors: Yvonne M. Chen, Henry B. Lowman, Yves Muller