Patents by Inventor Yvonne M. Janssen-Heininger
Yvonne M. Janssen-Heininger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210311057Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc.Type: ApplicationFiled: February 22, 2021Publication date: October 7, 2021Applicants: The University of Vermont and State Agricultural College, Universiteit MaastrichtInventors: Yvonne M. Janssen-Heininger, Niki Reynaert
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Publication number: 20200276263Abstract: The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.Type: ApplicationFiled: May 14, 2020Publication date: September 3, 2020Applicant: The University of Vermont and State Agricultural CollegeInventors: Yvonne M. Janssen-Heininger, Vikas Anathy
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Patent number: 10688150Abstract: The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.Type: GrantFiled: January 18, 2018Date of Patent: June 23, 2020Assignee: The Univserity of Vermont and State Agricultural CollegeInventors: Yvonne M. Janssen-Heininger, Vikas Anathy
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Publication number: 20180221436Abstract: The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.Type: ApplicationFiled: January 18, 2018Publication date: August 9, 2018Applicant: The University of Vermont and State Agricultural CollegeInventors: Yvonne M. Janssen-Heininger, Vikas Anathy
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Publication number: 20180224452Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc.Type: ApplicationFiled: February 1, 2018Publication date: August 9, 2018Applicants: The University of Vermont and State Agricultural College, Universiteit MaastrichtInventors: Yvonne M. Janssen-Heininger, Niki Reynaert
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Patent number: 9907828Abstract: The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.Type: GrantFiled: June 20, 2013Date of Patent: March 6, 2018Assignee: The University of Vermont and State Agricultural CollegeInventors: Yvonne M. Janssen-Heininger, Vikas Anathy
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Publication number: 20150157686Abstract: The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.Type: ApplicationFiled: June 20, 2013Publication date: June 11, 2015Applicant: The University of Vermont and State Agricultural CollegeInventors: Yvonne M. Janssen-Heininger, Vikas Anathy
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Publication number: 20150056633Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc.Type: ApplicationFiled: September 18, 2014Publication date: February 26, 2015Applicants: The University of Vermont and State Agricultural College, Universiteit MaastrichtInventors: Yvonne M. Janssen-Heininger, Niki Reynaert
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Patent number: 8877447Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc.Type: GrantFiled: January 25, 2007Date of Patent: November 4, 2014Assignees: The University of Vermont and State Agriculture College, Universiteit MaastrichtInventors: Yvonne M. Janssen-Heininger, Niki Reynaert
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Publication number: 20140140975Abstract: The present invention generally relates to treatments involving glutaredoxins. In one aspect, systems and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, airway inflammation or asthma. In some embodiments, a glutaredoxin may be used to treat a subject. Also provided in certain aspects of the present invention are kits for therapies involving glutaredoxins, methods for promoting such therapies, and the like.Type: ApplicationFiled: November 12, 2013Publication date: May 22, 2014Applicants: Universiteit Maastricht, The University of Vermont and State Agricultural CollegeInventors: Yvonne M. Janssen-Heininger, Niki Reynaert, Vikas Anathy, Scott Aesif
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Patent number: 8679811Abstract: The present invention generally relates to treatments involving glutaredoxins. In one aspect, systems and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, airway inflammation or asthma. In some embodiments, a glutaredoxin may be used to treat a subject. Also provided in certain aspects of the present invention are kits for therapies involving glutaredoxins, methods for promoting such therapies, and the like.Type: GrantFiled: June 10, 2008Date of Patent: March 25, 2014Assignees: The University of Vermont and State Agricultural College, Universiteit MaastrichtInventors: Yvonne M. Janssen-Heininger, Niki Lea Reynaert, Vikas Anathy, Scott Aesif
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Publication number: 20100266566Abstract: The present invention generally relates to treatments involving glutaredoxins. In one aspect, systems and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, airway inflammation or asthma. In some embodiments, a glutaredoxin may be used to treat a subject. Also provided in certain aspects of the present invention are kits for therapies involving glutaredoxins, methods for promoting such therapies, and the like.Type: ApplicationFiled: June 10, 2008Publication date: October 21, 2010Inventors: Yvonne M. Janssen-Heininger, Niki Lea Reynaert, Vikas Anathy, Scott Aesif